STANDARD_NAME LY_AGING_MIDDLE_UP SYSTEMATIC_NAME M19146 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LY_AGING_MIDDLE_UP NAMESPACE AFFY_HuGene DESCRIPTION_BRIEF Genes up-regulated in fibroblasts from middle-age individuals, compared to those from the young donors. DESCRIPTION_FULL Messenger RNA levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria, a rare genetic disorder characterized by accelerated aging. Genes whose expression is associated with age-related phenotypes and diseases were identified. The data also suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of life. We propose that this dysfunction leads to chromosomal pathologies that result in misregulation of genes involved in the aging process. PMID 10741968 GEOID AUTHORS Ly DH,Lockhart DJ,Lerner RA,Schultz PG CONTRIBUTOR John Newman CONTRIBUTOR_ORG University of Washington EXACT_SOURCE Table 1, 2: Middle Age: FoldD > 0 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS D87258_at,HG4480-HT4833_at,L10035_at,L12350_at,L23808_at,L25286_s_at,L32137_at,M31551_s_at,M59979_at,U05291_at,U62800_at,U94332_at,X07820_at,Y00787_s_at,Z22865_at GENE_SYMBOLS HTRA1,,CRYBB2,THBS2,MMP12,COL15A1,COMP,SERPINB2,PTGS1,FMOD,CST6,TNFRSF11B,MMP10,CXCL8,DPT FOUNDER_NAMES