STANDARD_NAME MARCHINI_TRABECTEDIN_RESISTANCE_DN SYSTEMATIC_NAME M8349 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/MARCHINI_TRABECTEDIN_RESISTANCE_DN NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF Genes down-regulated in chondrosarcoma and ovarian carcinoma cell lines which developed resistance to trabectedin [PubChem=3199]. DESCRIPTION_FULL ET-743 (Yondelis(TM), Trabectedin) isolated from the tunicate Ecteinascidia turbinata, is being tested in phase II clinical trials in Europe and the United States of America (USA). Studies with different solid tumours have shown antitumour activity in advanced, pre-treated sarcomas as well as in drug-resistant breast and ovarian cancer. The primary mechanism of action for ET-743 has not been fully elucidated and different models have been suggested to explain its molecular mechanism of action. ET-743 binds tightly to the minor groove of DNA and previous data have suggested that ET-743 acts by interfering with RNA transcription. To further investigate the mechanism of in vitro drug resistance, we evaluated the gene expression profile in ovarian and chondrosarcoma cell lines selected for resistance to ET-743. We found 70 genes whose expression was modulated in both drug-resistant cell lines when compared with their respective parental drug-sensitive cell lines. This pattern of gene expression seems to be selective for ET-743-resistant cells, since ovarian cancer cells resistant to paclitaxel did not share the same gene expression changes. Data presented in this study reveal different molecular pathways that could be involved in the cellular mechanism of ET-743 resistance. PMID 15661559 GEOID AUTHORS Marchini S,Marrazzo E,Bonomi R,Chiorino G,Zaffaroni M,Weissbach L,Hornicek FJ,Broggini M,Faircloth GT,D'Incalci M CONTRIBUTOR John Newman CONTRIBUTOR_ORG University of Washington EXACT_SOURCE Suppl. file: CHS & Igrovs with common trend: down FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AB002373,AB004066,AF035119,D13748,D14874,D26181,D78586,D86043,D88378,J02853,J02939,J05016,J05272,K03515,L08485,L21186,L34058,L42024,M13899,M19267,M30269,M35250,M64098,M77198,M77836,M80244,M84739,M86406,S75725,S76730,S82240,U06863,U26710,U53347,U65093,U79294,U81800,U97669,X04098,X05562,X13839,X14420,X15187,X67734,X83425,X83703,X87949,X94754,Z50022 GENE_SYMBOLS RUSC2,BHLHE40,DLC1,EIF4A1,ADM,PKN1,CAD,SIRPA,PSMF1,CSNK2A1,SLC3A2,,IMPDH1,GPI,GABRA5,LOXL1,CDH13,HLA-B,PRNP,,NID1,,HDLBP,AKT2,PYCR1,SLC7A5,CALR,ACTN2,IGFBP7,PLXNB2,RND3,FSTL1,CBLB,SLC1A5,CITED2,PLPP3,SLC16A3,NOTCH3,ACTG1,COL4A2,ACTA2,COL3A1,HSP90B1,CNTN2,BCAM,ANKRD1,HSPA5,MARS1,PTTG1IP FOUNDER_NAMES