STANDARD_NAME MARTENS_BOUND_BY_PML_RARA_FUSION SYSTEMATIC_NAME M2094 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/MARTENS_BOUND_BY_PML_RARA_FUSION NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes with promoters occupied by PML-RARA fusion [GeneID=5371,5914] protein in acute promyelocytic leukemia(APL) cells NB4 and two APL primary blasts, based on Chip-seq data. DESCRIPTION_FULL Many different molecular mechanisms have been associated with PML-RARalpha-dependent transformation of hematopoietic progenitors. Here, we identified high confidence PML-RARalpha binding sites in an acute promyelocytic leukemia (APL) cell line and in two APL primary blasts. We found colocalization of PML-RARalpha with RXR to the vast majority of these binding regions. Genome-wide epigenetic studies revealed that treatment with pharmacological doses of all-trans retinoic acid induces changes in H3 acetylation, but not H3K27me3, H3K9me3, or DNA methylation at the PML-RARalpha/RXR binding sites or at nearby target genes. Our results suggest that PML-RARalpha/RXR functions as a local chromatin modulator and that specific recruitment of histone deacetylase activities to genes important for hematopoietic differentiation, RAR signaling, and epigenetic control is crucial to its transforming potential. PMID 20159609 GEOID GSE18886 AUTHORS Martens JH,Brinkman AB,Simmer F,Francoijs KJ,Nebbioso A,Ferrara F,Altucci L,Stunnenberg HG CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table S3 PMLRAR common FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABHD2,ABI3,ACP5,ACSF3,ACSL1,ADAM8,ADAMTS10,ADC,ADCY10,ADORA3,ADRBK1,AJAP1,AK1,AKNA,ALDH2,ALOX5AP,ANKDD1A,ANKRD11,ANKRD33B,ANP32E,ANXA11,APBB1IP,APLP2,ARAP1,ARHGAP30,ARHGEF2,ARID2,ARID3B,ARRB1,ASB2,ATG16L2,ATP2B4,ATP6V0C,ATP8B4,AUH,B3GNT7,B4GALT1,BAGE2,BANF1,BANP,BCL3,BHLHE40,BLM,BRE,BRF1,BZRAP1,C10orf137,C11orf21,C12orf24,C15orf39,C19orf36,C1orf106,C1orf132,C1orf183,C1orf55,C1orf85,C1orf86,C20orf197,C20orf43,C3orf19,C3orf27,C5AR1,C5orf62,C9orf139,C9orf47,CACNA1C,CAMK2G,CAPG,CCDC114,CCDC88B,CCDC94,CCND3,CD164,CD58,CD82,CDH23,CDK5,CDK9,CDS2,CETP,CHD7,CHST15,CISH,CORO2A,COTL1,CPNE9,CRAMP1L,CRTC1,CSK,CSTF1,CTCF,CTSD,CUEDC1,CUGBP2,CUTA,CUX1,CXCR5,CXXC5,CYTH4,DAPK2,DCAF11,DCTN1,DCTN4,DDIT4,DDX5,DEF6,DENND3,DNAJB12,DNM2,DOK3,DOT1L,DRG2,DUSP28,DUSP5,ECE1,EFHD2,ELAVL1,ELF4,ELL,EMR2,ENSA,EXOSC4,F11R,FAM129C,FAM159A,FAM53B,FAM78A,FAM89B,FAM96A,FBXO46,FCGRT,FCN1,FERMT3,FGFR1OP2,FGR,FHOD1,FLNB,FLT3,FMNL1,FNBP1,FOSB,FOSL2,FRAT1,FXYD6,GALC,GALK2,GALNT6,GAS7,GBA,GBE1,GFOD1,GGA1,GNB2,GNB5,GPATCH8,GPR114,GPR132,GPR97,GRIP2,GRK5,GRK6,GTF3A,GUSB,H6PD,HCK,HDAC4,HECW1,HIP1,HIVEP2,HIVEP3,HMGA1,HMHA1,HMOX1,HNRNPM,HPCAL1,ICAM1,ICAM4,ID1,ID2,IDH1,IFITM3,IFNAR2,INHBA,IQCD,IQSEC1,IRF1,IRF2BP2,IRF8,ITGA4,ITGB2,ITPR1,ITPR2,JUND,KCNAB2,KIAA0020,KIAA0182,KIAA1539,KLF13,KLF2,KLHDC4,KLHL24,KPTN,KREMEN1,KRI1,KSR1,LAPTM5,LASP1,LATS2,LBR,LCP2,LETMD1,LFNG,LMBR1,LMO2,LRRC20,LRRC29,LTB4R,LTBP3,LYL1,LYN,MAFB,MAML2,MAP2K3,MBD6,MBP,MCAM,MCM5,MDM1,MEF2D,MFN1,MFSD8,MGLL,MIDN,MIR223,MIR23A,MIR24-2,MIR29B1,MIR663,MLXIPL,MMP9,MN1,MORN3,MPG,MRPL1,MRPL24,MRPL34,MRVI1,MTRF1L,MX2,MYH9,MYO1F,MYO9B,NADK,NBR1,NCOR2,NCRNA00173,NDRG1,NDUFA4,NEK6,NFE2,NINJ1,NLRP3,NME1-NME2,NMUR1,NOLC1,NOSIP,NPAS4,NRXN2,NUAK2,NUDT15,NUDT3,NUDT9,NUP210,NUP85,NUTF2,OAZ1,OLIG1,OLIG2,P2RY2,PAFAH2,PDE4DIP,PDP2,PEBP4,PEX12,PGC,PGD,PGLS,PGPEP1,PHF12,PIGL,PIK3AP1,PITPNM2,PIWIL4,PKIG,PKM2,PLAC8,PLCB2,PLCG2,PLEK,PLEKHA2,PLEKHO1,PLXND1,PMF1,PPCDC,PREX1,PRKCD,PSAP,PSMD3,PSMD9,PTEN,PTGES,PTPN6,PTPRJ,PVRL1,PVRL4,PXN,RAB11FIP1,RAB11FIP3,RAB20,RAB31,RAB37,RAB3D,RAB43,RAC2,RAP1GAP2,RAPGEF1,RARA,RASA3,RASGRP2,RAVER1,RBBP8,RCSD1,RFX2,RHBDF2,RNF122,RNF149,RNF34,RPL24,RPL9,RPS19,RPS6,RPS6KA1,RPS6KA2,RPS9,RSL24D1,RSRC2,RUNX1,RUNX3,RUVBL1,RWDD1,SCARB1,SCUBE1,SEC11A,SEC11B,SERPINB1,SETD8,SF3A3,SH2B1,SH3BGRL3,SH3BP2,SH3PXD2A,SIK1,SIRPA,SKI,SLC22A11,SLC24A3,SLC25A19,SLC35B1,SLC6A6,SLC7A10,SLC7A5,SLC7A5P1,SLC9A1,SLC9A3,SMAD3,SMG6,SNX20,SPG7,SPHK2,SPI1,SPN,SPTBN1,SQSTM1,SREBF1,ST3GAL2,STK24,STRADA,STXBP2,SULF2,SUSD3,SYT2,TAGLN2,TARBP1,TARS2,TBP,TBX6,TBXAS1,TESC,TFDP1,TIMP2,TK2,TM9SF4,TMC8,TMCC2,TMEM104,TMEM115,TMEM143,TMEM148,TMEM173,TMEM41B,TNFAIP2,TNFAIP3,TNFRSF10B,TNFRSF4,TOMM20,TOMM40,TOX2,TPD52L2,TPPP3,TPR,TPRA1,TRIM72,TRIP4,TRNP1,TSSK3,TUBA1C,TUBGCP2,TYK2,TYROBP,UACA,UBASH3B,UBE2O,UBE2R2,UBL3,UBN2,UCK2,UPB1,UPP1,VASP,WDR26,WDR51A,WDR81,WNT5B,WNT9A,YTHDF2,ZBTB16,ZBTB3,ZC3H12A,ZC3H4,ZDHHC19,ZFYVE28,ZMIZ1,ZNF595,ZNF683,ZNF710,ZZEF1 GENE_SYMBOLS ABHD2,ABI3,ACP5,ACSF3,ACSL1,ADAM8,ADAMTS10,AZIN2,ADCY10,ADORA3,GRK2,AJAP1,AK1,AKNA,ALDH2,ALOX5AP,ANKDD1A,ANKRD11,ANKRD33B,ANP32E,ANXA11,APBB1IP,APLP2,ARAP1,ARHGAP30,ARHGEF2,ARID2,ARID3B,ARRB1,ASB2,ATG16L2,ATP2B4,ATP6V0C,ATP8B4,AUH,B3GNT7,B4GALT1,BAGE2,BANF1,BANP,BCL3,BHLHE40,BLM,BABAM2,BRF1,TSPOAP1,EDRF1,C11orf21,FAM216A,C15orf39,IZUMO4,INAVA,MIR29B2CHG,INKA2,SDE2,GLMP,FAAP20,LINC02910,RTF2,CCDC174,LINC01565,C5AR1,SMIM3,LINC02908,S1PR3,CACNA1C,CAMK2G,CAPG,ODAD1,CCDC88B,YJU2,CCND3,CD164,CD58,CD82,CDH23,CDK5,CDK9,CDS2,CETP,CHD7,CHST15,CISH,CORO2A,COTL1,CPNE9,CRAMP1,CRTC1,CSK,CSTF1,CTCF,CTSD,CUEDC1,CELF2,CUTA,CUX1,CXCR5,CXXC5,CYTH4,DAPK2,DCAF11,DCTN1,DCTN4,DDIT4,DDX5,DEF6,DENND3,DNAJB12,DNM2,DOK3,DOT1L,DRG2,DUSP28,DUSP5,ECE1,EFHD2,ELAVL1,ELF4,ELL,ADGRE2,ENSA,EXOSC4,F11R,NIBAN3,SHISAL2A,FAM53B,FAM78A,FAM89B,CIAO2A,FBXO46,FCGRT,FCN1,FERMT3,FGFR1OP2,FGR,FHOD1,FLNB,FLT3,FMNL1,FNBP1,FOSB,FOSL2,FRAT1,FXYD6,GALC,GALK2,GALNT6,GAS7,GBA1,GBE1,GFOD1,GGA1,GNB2,GNB5,GPATCH8,ADGRG5,GPR132,ADGRG3,GRIP2,GRK5,GRK6,GTF3A,GUSB,H6PD,HCK,HDAC4,HECW1,HIP1,HIVEP2,HIVEP3,HMGA1,ARHGAP45,HMOX1,HNRNPM,HPCAL1,ICAM1,ICAM4,ID1,ID2,IDH1,IFITM3,IFNAR2,INHBA,IQCD,IQSEC1,IRF1,IRF2BP2,IRF8,ITGA4,ITGB2,ITPR1,ITPR2,JUND,KCNAB2,PUM3,GSE1,ATOSB,KLF13,KLF2,KLHDC4,KLHL24,KPTN,KREMEN1,KRI1,KSR1,LAPTM5,LASP1,LATS2,LBR,LCP2,LETMD1,LFNG,LMBR1,LMO2,LRRC20,FBXL9P,LTB4R,LTBP3,LYL1,LYN,MAFB,MAML2,MAP2K3,MBD6,MBP,MCAM,MCM5,MDM1,MEF2D,MFN1,MFSD8,MGLL,MIDN,MIR223,MIR23A,MIR24-2,MIR29B1,MIR663A,MLXIPL,MMP9,MN1,MORN3,MPG,MRPL1,MRPL24,MRPL34,IRAG1,MTRF1L,MX2,MYH9,MYO1F,MYO9B,NADK,NBR1,NCOR2,LINC00173,NDRG1,NDUFA4,NEK6,NFE2,NINJ1,NLRP3,NME1-NME2,NMUR1,NOLC1,NOSIP,NPAS4,NRXN2,NUAK2,NUDT15,NUDT3,NUDT9,NUP210,NUP85,NUTF2,OAZ1,OLIG1,OLIG2,P2RY2,PAFAH2,PDE4DIP,PDP2,PEBP4,PEX12,PGC,PGD,PGLS,PGPEP1,PHF12,PIGL,PIK3AP1,PITPNM2,PIWIL4,PKIG,PKM,PLAC8,PLCB2,PLCG2,PLEK,PLEKHA2,PLEKHO1,PLXND1,PMF1,PPCDC,PREX1,PRKCD,PSAP,PSMD3,PSMD9,PTEN,PTGES,PTPN6,PTPRJ,NECTIN1,NECTIN4,PXN,RAB11FIP1,RAB11FIP3,RAB20,RAB31,RAB37,RAB3D,RAB43,RAC2,RAP1GAP2,RAPGEF1,RARA,RASA3,RASGRP2,RAVER1,RBBP8,RCSD1,RFX2,RHBDF2,RNF122,RNF149,RNF34,RPL24,RPL9,RPS19,RPS6,RPS6KA1,RPS6KA2,RPS9,RSL24D1,RSRC2,RUNX1,RUNX3,RUVBL1,RWDD1,SCARB1,SCUBE1,SEC11A,SEC11B,SERPINB1,KMT5A,SF3A3,SH2B1,SH3BGRL3,SH3BP2,SH3PXD2A,SIK1,SIRPA,SKI,SLC22A11,SLC24A3,SLC25A19,SLC35B1,SLC6A6,SLC7A10,SLC7A5,SLC7A5P1,SLC9A1,SLC9A3,SMAD3,SMG6,SNX20,SPG7,SPHK2,SPI1,SPN,SPTBN1,SQSTM1,SREBF1,ST3GAL2,STK24,STRADA,STXBP2,SULF2,SUSD3,SYT2,TAGLN2,TARBP1,TARS2,TBP,TBX6,TBXAS1,TESC,TFDP1,TIMP2,TK2,TM9SF4,TMC8,TMCC2,TMEM104,TMEM115,TMEM143,LINC00311,STING1,TMEM41B,TNFAIP2,TNFAIP3,TNFRSF10B,TNFRSF4,TOMM20,TOMM40,TOX2,TPD52L2,TPPP3,TPR,TPRA1,TRIM72,TRIP4,TRNP1,TSSK3,TUBA1C,TUBGCP2,TYK2,TYROBP,UACA,UBASH3B,UBE2O,UBE2R2,UBL3,UBN2,UCK2,UPB1,UPP1,VASP,WDR26,POC1A,WDR81,WNT5B,WNT9A,YTHDF2,ZBTB16,ZBTB3,ZC3H12A,ZC3H4,ZDHHC19,ZFYVE28,ZMIZ1,ZNF595,ZNF683,ZNF710,ZZEF1 FOUNDER_NAMES