STANDARD_NAME	MARTINELLI_IMMATURE_NEUTROPHIL_DN
SYSTEMATIC_NAME	M5149
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/MARTINELLI_IMMATURE_NEUTROPHIL_DN
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Neutrophil-specific genes down-regulated in comparison of immature with mature neutrophils.
DESCRIPTION_FULL	Interferons (IFNs) are cytokines that possess potent anti-viral and immunoregulatory activities. In contrast, their potential role(s) in anti-bacterial defense and neutrophil activation mechanisms is less well explored. By comparing gene expression patterns between immature and mature human neutrophils, we obtained evidence that intracellular proteases and other anti-bacterial proteins are produced at earlier stages of maturation, whereas the genes for receptors and signaling molecules required for the release of these effector molecules are preferentially induced during terminal differentiation. For instance, mature neutrophils strongly expressed genes that increase their responses to type I and type II IFNs. Interestingly, granulocyte/macrophage colony-stimulating factor was identified as a repressor of IFN signaling components and consequently of IFN-responsive genes. Both IFN-alpha and IFN-gamma induced strong tyrosine phosphorylation of STAT1 in mature but not in immature neutrophils. Functional in vitro studies suggested that IFNs act as priming factors on mature neutrophils, allowing the formation of extracellular traps upon subsequent stimulation with complement factor 5a (C5a). In contrast, both IFN-alpha and IFN-gamma had only little capacity to prime immature cells in this system. Moreover, both IFNs did not have significant anti-proliferative effects on immature neutrophils. These data contribute to our understanding regarding changes of gene expression during neutrophil differentiation and IFN-mediated anti-bacterial defense mechanisms.
PMID	15302890
GEOID	
AUTHORS	Martinelli S,Urosevic M,Daryadel A,Oberholzer PA,Baumann C,Fey MF,Dummer R,Simon HU,Yousefi S
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 4: Mature neutrophils
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AB000220,AB011406,D10923,J04162,L19593,M28130,M32011,M59818,M59820,M62840,U11870,U14550,X07834,X16863,X68090
GENE_SYMBOLS	SEMA3C,ALPL,HCAR3,FCGR3B,CXCR2,CXCL8,NCF2,CSF3R,CSF3R,AOAH,CXCR1,ST6GALNAC2,SOD2,FCGR3B,FCGR2A
FOUNDER_NAMES