STANDARD_NAME	MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN
SYSTEMATIC_NAME	M1125
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN
NAMESPACE	MOUSE_GENE_SYMBOL
DESCRIPTION_BRIEF	Pubertal genes down-regulated by TGFB1 [GeneID=7040].
DESCRIPTION_FULL	Expression microarray analysis identified over 930 genes regulated during puberty in the mouse mammary gland. Most prominent were genes whose expression increased in parallel with pubertal development and remained high thereafter. Members of the Wnt, transforming growth factor-beta and oestrogen-signalling pathways were significantly overrepresented. Comparison to expression data from CITED1 knockout mice identified a subset of oestrogen-responsive genes displaying altered expression in the absence of CITED1. Included in this subset are stanniocalcin2 (Stc2) and amphiregulin (Areg). Chromatin immunoprecipitation revealed that ERalpha binds to oestrogen response elements in both the Stc2 and Areg genes in the mammary gland during puberty. Additionally, CITED1 and ERalpha localize to the same epithelial cells of the pubertal mammary gland, supporting a role for interaction of these two proteins during normal development. In a human breast cancer data set, expression of Stc2, Areg and CITED1 parallel that of ERalpha. Similar to ERalpha, CITED1 expression correlates with good outcome in breast cancer, implying that potential maintenance of the ERalpha-CITED1 co-regulated signalling pathway in breast tumours can indicate good prognosis.
PMID	17486082
GEOID	GSE6453
AUTHORS	McBryan J,Howlin J,Kenny PA,Shioda T,Martin F
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 3S: regulation by TGFbeta = dn
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	Abcc3,Adm,Aldh1a1,Apoc2,Apod,Areg,Arhgef3,Bcl3,Bcl6,Cd9,Cdh1,Cdh5,Chi3l1,Cldn4,Csnk,Dapk1,Ednra,Erbb3,Gata3,Gclc,Gsta3,Gzma,Hspa1b,Idb2,Idb4,Idh1,Ifit3,Igj,Kitl,Klf5,Lcn2,Lrp5,Mbtps1,Mt2,Nfkb2,Nid1,Nid2,Pdk4,Pfn2,Phlda1,Ppap2c,Ppp1r3c,Ptgis,Ptn,Pttg1,Ptx3,Rab27b,Rbbp4,Rbm5,Rgs2,Sfrp1,Sftpb,Sftpd,Slc12a2,Slc9a3r1,Slpi,Sod2,Spint2,Tcf7,Tnfaip2,Tyr,Vapb,Vwf
GENE_SYMBOLS	ABCC3,ADM,ALDH1A1,APOC2,APOD,AREG,ARHGEF3,BCL3,BCL6,CD9,CDH1,CDH5,CHI3L1,CLDN4,CSN3,DAPK1,EDNRA,ERBB3,GATA3,GCLC,,GZMA,HSPA1B,ID2,ID4,IDH1,IFIT3,JCHAIN,KITLG,KLF5,LCN2,LRP5,MBTPS1,MT1X,NFKB2,NID1,NID2,PDK4,PFN2,PHLDA1,PLPP2,PPP1R3C,PTGIS,PTN,PTTG1,PTX3,RAB27B,RBBP4,RBM5,RGS2,SFRP1,SFTPB,SFTPD,SLC12A2,NHERF1,SLPI,SOD2,SPINT2,TCF7,TNFAIP2,TYR,VAPB,VWF
FOUNDER_NAMES