STANDARD_NAME MOOTHA_PGC SYSTEMATIC_NAME M9788 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/MOOTHA_PGC NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [GeneID=10891] off an adenoviral vector. DESCRIPTION_FULL DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments. PMID 12808457 GEOID AUTHORS Mootha VK,Lindgren CM,Eriksson KF,Subramanian A,Sihag S,Lehar J,Puigserver P,Carlsson E,Ridderstråle M,Laurila E,Houstis N,Daly MJ,Patterson N,Mesirov JP,Golub TR,Tamayo P,Spiegelman B,Lander ES,Hirschhorn JN,Altshuler D,Groop LC CONTRIBUTOR Vamsi Mootha CONTRIBUTOR_ORG Broad Institute EXACT_SOURCE unknown FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA2,ABCF1,ABHD5,ACADL,ACADM,ACADS,ACO2,ACTR2,ACYP1,ACYP2,ADSL,ADSS,AES,AGPAT3,AK1,AKAP1,AKIP,AKR1B10,ALAS1,ALS2CR3,AMACR,APBA3,APG-1,ARHD,ARIH1,ARMET,ARVCF,ATP1A1,ATP1B1,ATP2A3,ATP5A1,ATP5C1,ATP5L,ATP5O,ATP6V1D,BACH,BAT3,BID,BNIP3L,BSG,C14orf2,C14orf87,C20orf45,C21orf97,C6orf209,C7orf32,C9orf16,CA2,CA4,CARHSP1,CDC34,CDKN2D,CGI-128,CHP,CHRNE,CIA30,CIAO1,CKIP-1,CKMT2,CKS2,CLPP,CMKOR1,CNOT7,COH1,COL7A1,COMT,COPS3,COX5B,COX6A1,COX7A1,COX7A2,COX7B,COX7C,COX8,CPR2,CPT1A,CRAT,CRLF3,CRMP1,CS,CTSF,CX3CL1,CYC1,CYCS,DBI,DC13,DDT,DFFA,DGAT1,DHX16,DKFZp434O0213,DKFZp564B167,DKFZp586D0919,DLD,DNAJA3,DNAJB9,DNAJD1,DOM3Z,DPYSL3,DRPLA,DUSP1,DUSP6,E2IG5,ECGF1,EDNRA,EEF1A2,EFG1,EGLN1,EIF3S6IP,EIF4A2,ENO1,ERO1L,ESRRA,ETFB,F2RL2,FABP3,FAM18B,FARS1,FASTK,FBS1,FDX1,FH,FLJ10134,FLJ10420,FLJ10511,FLJ11560,FLJ12598,FLJ13612,FLJ20758,FLJ22390,FLJ22555,FOS,FOXM1,FRAP1,FXC1,FXR2,FZD4,GABARAPL1,GABPA,GAF1,GAPD,GATA3,GBAS,GCDH,GCH1,GHITM,GK,GLRX,GNA13,GOLPH3,GPI,GPX4,GRCC9,GRPEL1,GRSF1,GSS,GSTO1,GTF2H4,GTPBP2,GTPBP4,GUK1,GYS1,H11,HADH2,HADHB,HBA1,HBD,HCCS,HLA-DRA,HMGB3,HRI,HSPA5,HSPA9B,HSPBP1,HSPC051,HSPC132,HSPD1,HSPE1,HSU79266,HUMPPA,ICT1,ID2,IDH2,IDH3A,IDH3G,IFI16,IFRD1,INHBA,ITPK1,ITPR2,KCNN1,KIAA0033,KIAA0103,KIAA0205,KIDINS220,LATS1,LCN2,LCN7,LDHA,LDHB,LOC123803,LPIN1,LRBA,LRP5,LRPPRC,LRRFIP2,LSM1,LSM8,MAL,MAP2K1,MAP2K3,MAPK8,MAPKAPK2,MARS,MAT2B,MDH2,MDS029,ME1,MFN1,MGC10940,MGC15396,MGC29816,MGC3047,MGC4276,MGC5139,MKRN3,MNDA,MO25,MPP5,MRPL11,MRPL13,MRPL15,MRPL18,MRPL20,MRPL34,MRPL39,MRPL4,MRPL40,MRPL46,MRPS12,MRPS17,MRPS18A,MRPS18B,MRPS2,MRPS34,MT2A,MTCH2,MTHFD2,MTX1,MTX2,MUC5AC,MYH11,MYL2,NCAM1,NDRG2,NDRG4,NDUFA5,NDUFA6,NDUFA8,NDUFAB1,NDUFB3,NDUFB5,NDUFB6,NDUFC1,NDUFS3,NDUFS5,NDUFV2,NFIX,NFS1,NFYC,NGFRAP1,NINJ1,NME7,NOLA3,NPPB,NR0B2,NRP1,NSF,OAZIN,OSBPL1A,OXCT,P4HA2,PCK1,PCOLCE,PCTK3,PCYT2,PDCD6,PDCD8,PDGFRB,PDHA1,PDHB,PDIP38,PDK4,PDXK,PFKM,PFKP,PGAM1,PGK1,PGLS,PGM1,PHLDA1,PHYH,PIB5PA,PIGQ,PKM2,PLA2G12,PLAB,PMM1,POLR2E,POLR2F,POPDC2,PPM1G,PRDX2,PRDX3,PRSS15,PSCA,PSMA5,PSMA6,PSMB10,PSMB5,PSMB7,PSME3,PTDSR,PTDSS2,PTGES2,PTK9L,PTPRD,PUS1,PYGM,RAB31,RAB40C,RAMP3,RANGAP1,RANGNRF,REA,REC14,RNF5,RPA3,RRM1,RRM2,RTN4,RTP801,RUVBL2,RXRB,S100A1,S100A13,SACM1L,SARA2,SAT,SCD,SCN1B,SDHA,SDHB,SEPX1,SF1,SGTA,SH3BGR,SHMT1,SIAT7D,SKIV2L,SLC12A7,SLC20A1,SLC25A11,SLC25A20,SLC25A4,SLC25A5,SLC2A4,SLC31A1,SMPD1,SNW1,SOD2,SOD3,SPINT1,SPP1,SPTLC2,SPUVE,SRC,STARD7,STK16,STK19,SUCLA2,SUCLG1,SUPV3L1,SZF1,TARBP1,TBL1X,TCIRG1,TCN2,TFB2M,TFRC,THEM2,TIMM13,TIMM17A,TIMM23,TIMM44,TIMM8A,TIMM8B,TM4SF12,TMX2,TNNI3,TOMM40,TPI1,TSC2,TTC1,TUFM,TXN2,UBC,UBE2B,UBL1,ULK1,UMPK,UNG,UPP1,UQCRB,UQCRC1,UROD,USP2,USP8,VAMP8,VDAC3,VEGF,VIP32,VIPR1,ZNF11B,ZNF216 GENE_SYMBOLS ABCA2,ABCF1,ABHD5,ACADL,ACADM,ACADS,ACO2,ACTR2,ACYP1,ACYP2,ADSL,ADSS2,TLE5,AGPAT3,AK1,AKAP1,AURKAIP1,AKR1B10,ALAS1,TRAK2,AMACR,APBA3,HSPA4L,RHOD,ARIH1,MANF,ARVCF,ATP1A1,ATP1B1,ATP2A3,ATP5F1A,ATP5F1C,ATP5MG,ATP5PO,ATP6V1D,ACOT7,BAG6,BID,BNIP3L,BSG,ATP5MJ,GLRX5,PRELID3B,PDXK,LMBRD1,ATP6V0E2,BBLN,CA2,CA4,CARHSP1,CDC34,CDKN2D,CIAO2B,CHP1,CHRNE,NDUFAF1,CIAO1,PLEKHO1,CKMT2,CKS2,CLPP,ACKR3,CNOT7,VPS13B,COL7A1,COMT,COPS3,COX5B,COX6A1,COX7A1,COX7A2,COX7B,COX7C,COX8A,,CPT1A,CRAT,CRLF3,CRMP1,CS,CTSF,CX3CL1,CYC1,CYCS,DBI,CMC2,DDT,DFFA,DGAT1,DHX16,LRP5L,MPC2,EEF1AKMT3,DLD,DNAJA3,DNAJB9,DNAJC15,DXO,DPYSL3,ATN1,DUSP1,DUSP6,FAM162A,TYMP,EDNRA,EEF1A2,,EGLN1,EIF3L,EIF4A2,ENO1,ERO1A,ESRRA,ETFB,F2RL2,FABP3,TVP23B,FARS2,FASTK,FBRS,FDX1,FH,TMEM45A,NECAP2,ARMC1,ATOSB,PTCD2,EFHD1,PTCD3,MTARC1,MAIP1,FOS,FOXM1,MTOR,TIMM10B,FXR2,FZD4,GABARAPL1,GABPA,RAB11FIP5,GAPDH,GATA3,NIPSNAP2,GCDH,GCH1,GHITM,GK,GLRX,GNA13,GOLPH3,GPI,GPX4,SPSB2,GRPEL1,GRSF1,GSS,GSTO1,GTF2H4,GTPBP2,GTPBP4,GUK1,GYS1,HSPB8,HSD17B10,HADHB,HBA1,HBD,HCCS,HLA-DRA,HMGB3,EIF2AK1,HSPA5,HSPA9,HSPBP1,UQCR10,TRIAP1,HSPD1,HSPE1,SAC3D1,CDR2L,MRPL58,ID2,IDH2,IDH3A,IDH3G,IFI16,IFRD1,INHBA,ITPK1,ITPR2,KCNN1,TMEM41B,EMC2,LPGAT1,KIDINS220,LATS1,LCN2,TINAGL1,LDHA,LDHB,NTAN1,LPIN1,LRBA,LRP5,LRPPRC,LRRFIP2,LSM1,LSM8,MAL,MAP2K1,MAP2K3,MAPK8,MAPKAPK2,MARS1,MAT2B,MDH2,CISD1,ME1,MFN1,,ANKRD40,CHMP7,MXRA8,ISCA1,UNC119B,MKRN3,MNDA,CAB39,PALS1,MRPL11,MRPL13,MRPL15,MRPL18,MRPL20,MRPL34,MRPL39,MRPL4,MRPL40,MRPL46,MRPS12,MRPS17,MRPS18A,MRPS18B,MRPS2,MRPS34,MT2A,MTCH2,MTHFD2,MTX1,MTX2,MUC5AC,MYH11,MYL2,NCAM1,NDRG2,NDRG4,NDUFA5,NDUFA6,NDUFA8,NDUFAB1,NDUFB3,NDUFB5,NDUFB6,NDUFC1,NDUFS3,NDUFS5,NDUFV2,NFIX,NFS1,NFYC,BEX3,NINJ1,NME7,NOP10,NPPB,NR0B2,NRP1,NSF,AZIN1,OSBPL1A,OXCT1,P4HA2,PCK1,PCOLCE,CDK18,PCYT2,PDCD6,AIFM1,PDGFRB,PDHA1,PDHB,POLDIP2,PDK4,PDXK,PFKM,PFKP,PGAM1,PGK1,PGLS,PGM1,PHLDA1,PHYH,INPP5J,PIGQ,PKM,PLA2G12A,GDF15,PMM1,POLR2E,POLR2F,POPDC2,PPM1G,PRDX2,PRDX3,LONP1,PSCA,PSMA5,PSMA6,PSMB10,PSMB5,PSMB7,PSME3,JMJD6,PTDSS2,PTGES2,TWF2,PTPRD,PUS1,PYGM,RAB31,RAB40C,RAMP3,RANGAP1,RANGRF,PHB2,SKIC8,RNF5,RPA3,RRM1,RRM2,RTN4,DDIT4,RUVBL2,RXRB,S100A1,S100A13,SACM1L,SAR1B,SAT1,SCD,SCN1B,SDHA,SDHB,MSRB1,SF1,SGTA,SH3BGR,SHMT1,ST6GALNAC4,SKIC2,SLC12A7,SLC20A1,SLC25A11,SLC25A20,SLC25A4,SLC25A5,SLC2A4,SLC31A1,SMPD1,SNW1,SOD2,SOD3,SPINT1,SPP1,SPTLC2,PRSS23,SRC,STARD7,STK16,STK19,SUCLA2,SUCLG1,SUPV3L1,ZNF589,TARBP1,TBL1X,TCIRG1,TCN2,TFB2M,TFRC,ACOT13,TIMM13,TIMM17A,TIMM23,TIMM44,TIMM8A,TIMM8B,TSPAN12,TMX2,TNNI3,TOMM40,TPI1,TSC2,TTC1,TUFM,TXN2,UBC,UBE2B,SUMO1,ULK1,UCK2,UNG,UPP1,UQCRB,UQCRC1,UROD,USP2,USP8,VAMP8,VDAC3,VEGFA,AVPI1,VIPR1,ZNF33B,ZFAND5 FOUNDER_NAMES