STANDARD_NAME	NAGY_TFTC_COMPONENTS_HUMAN
SYSTEMATIC_NAME	M2974
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/NAGY_TFTC_COMPONENTS_HUMAN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Composition of the 2 MDa human TFTC complex containing KAT2A [GeneID=2648].
DESCRIPTION_FULL	Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific transcriptional activators, several different co-activators and general transcription factors are necessary to access specific loci to allow precise initiation of RNA polymerase II transcription. As the dense chromatin folding of the genome does not allow the access of these sites by the huge multiprotein transcription machinery, remodelling is required to loosen up the chromatin structure for successful transcription initiation. In the present review, we summarize the recent evolution of our understanding of the function of two histone acetyl transferases (ATs) from metazoan organisms: GCN5 and PCAF. Their overall structure and the multiprotein complexes in which they are carrying out their activities are discussed. Metazoan GCN5 and PCAF are subunits of at least two types of multiprotein complexes, one having a molecular weight of 2 MDa (SPT3-TAF9-GCN5 acetyl transferase/TATA binding protein (TBP)-free-TAF complex/PCAF complexes) and a second type with about a size of 700 kDa (ATAC complex). These complexes possess global histone acetylation activity and locus-specific co-activator functions together with AT activity on non-histone substrates. Thus, their biological functions cover a wide range of tasks and render them indispensable for the normal function of cells. That deregulation of the global and/or specific AT activities of these complexes leads to the cancerous transformation of the cells highlights their importance in cellular processes. The possible effects of GCN5 and PCAF in tumorigenesis are also discussed.
PMID	17694077
GEOID	
AUTHORS	Nagy Z,Tora L
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1: hTFTC
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ADA,ADA2B,ADA3,ATXN7,GCN5,SAP130,SGF29,SPT3,SPT7L,TAF10,TAF12,TAF2,TAF4,TAF5,TAF5L,TAF6,TAF6L,TAF9,TAF9b,TRRAP
GENE_SYMBOLS	ADA,,TADA3,ATXN7,KAT2A,SAP130,SGF29,SUPT3H,SUPT7L,TAF10,TAF12,TAF2,TAF4,TAF5,TAF5L,TAF6,TAF6L,TAF9,,TRRAP
FOUNDER_NAMES