STANDARD_NAME NAKAJIMA_MAST_CELL SYSTEMATIC_NAME M389 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/NAKAJIMA_MAST_CELL NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF Top 50 most-increased mast cell specific genes. DESCRIPTION_FULL Mast cells (MCs) and eosinophils are thought to play important roles in evoking allergic inflammation. Cell-type--specific gene expression was screened among 12,000 genes in human MCs and eosinophils with the use of high-density oligonucleotide probe arrays. In comparison with other leukocytes, MCs expressed 140 cell-type--specific transcripts, whereas eosinophils expressed only 34. Among the transcripts for expected MC-specific proteins such as tryptase, major basic protein (MBP), which had been thought to be eosinophil specific, was ranked fourth in terms of amounts of increased MC-specific messenger RNA. Mature eosinophils were almost lacking this transcript. MCs obtained from 4 different sources (ie, lung, skin, adult peripheral blood progenitor--derived and cord blood progenitor--derived MCs, and eosinophils) were found to have high protein levels of MBP in their granules with the use of flow cytometric and confocal laser scanning microscopic analyses. The present finding that MCs can produce abundant MBP is crucial because many reports regarding allergic pathogenesis have been based on earlier findings that MBP was almost unique to eosinophils and not produced by MCs. (Blood. 2001;98:1127-1134) PMID 11493461 GEOID AUTHORS Nakajima T,Matsumoto K,Suto H,Tanaka K,Ebisawa M,Tomita H,Yuki K,Katsunuma T,Akasawa A,Hashida R,Sugita Y,Ogawa H,Ra C,Saito H CONTRIBUTOR Kevin Vogelsang CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AB000584,AB006780,AF001294,AF002672,AF022813,AF038844,AF045229,AF150241,AL050224,D11139,D16583,D86358,D87119,H68340,J04988,K01383,L35594,L76465,L78833,M15518,M16117,M19481,M25915,M26683,M28225,M33494,M63138,M68891,M69136,M69177,M73720,M89796,M93311,M94345,R92331,R93527,U03688,U18009,U50136,U78027,X06182,X06948,X51956,X56667,X64559,X67951,X75252,X76534,Y00451,Z26248 GENE_SYMBOLS GDF15,LGALS3,PHLDA2,VWA5A,TSPAN4,DUSP14,RGS10,HPGDS,CAVIN1,TIMP1,HDC,SIGLEC6,TRIB2,MT1F,HSP90AB1,MT1A,ENPP2,HPGD,BRCA1,PLAT,CTSG,,CLU,CCL2,,TPSAB1,,GATA2,CMA1,MAOB,,MS4A2,MT3,CAPG,MT1E,MT1H,CYP1B1,VAT1,LTC4S,BTK,KIT,FCER1A,ENO2,CALB2,CLEC3B,PRDX1,PEBP1,GPNMB,ALAS1,PRG2 FOUNDER_NAMES