STANDARD_NAME NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN SYSTEMATIC_NAME M41203 COLLECTION C7:VAX MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in myeloid dendritic cell 7d vs 0d in young adults (18-50) after exposure to Fluarix/Fluvirin , time point 7D DESCRIPTION_FULL Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons. We studied healthy adults vaccinated with trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). TIV induced higher antibody titers and more plasmablasts than LAIV did. In subjects vaccinated with TIV, early molecular signatures correlated with and could be used to accurately predict later antibody titers in two independent trials. Notably, expression of the kinase CaMKIV at day 3 was inversely correlated with later antibody titers. Vaccination of CaMKIV-deficient mice with TIV induced enhanced antigen-specific antibody titers, which demonstrated an unappreciated role for CaMKIV in the regulation of antibody responses. Thus, systems approaches can be used to predict immunogenicity and provide new mechanistic insights about vaccines. PMID 21743478 GEOID AUTHORS Nakaya HI,Wrammert J,Lee EK,Racioppi L,Marie-Kunze S,Haining WN,Means AR,Kasturi SP,Khan N,Li GM,McCausland M,Kanchan V,Kokko KE,Li S,Elbein R,Mehta AK,Aderem A,Subbarao K,Ahmed R,Pulendran B CONTRIBUTOR HIPC SIGNATURES CONTRIBUTOR_ORG NIAID/HIPC SIGNATURES EXACT_SOURCE Supplementary Table 2a: TIV-mDC FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140559/bin/NIHMS301940-supplement-3.xlsx SOURCE_MEMBERS AFF4,AGPAT3,AKAP8L,AMMECR1,ANKRD17,AQP3,ARHGAP26,ARHGEF7,ARHGEF9,ARL3,ARL4C,ARNT,ATF7IP,ATP2B4,ATP5S,ATP6V0A1,ATP8A1,AUTS2,BCL2,BIRC5,BLNK,BRWD1,BTN2A3,C11orf57,C16orf57,C22orf30,C2CD3,CAMSAP1,CASK,CBFA2T2,CBL,CC2D1A,CCDC94,CCND2,CCNJ,CD164,CD47,CDC42BPA,CDHR5,CDK4,CDYL,CEBPD,CENPF,CENPN,CES2,CHD4,CHD8,CHST10,CKS1B,CLN8,COPS2,COX11,CTSA,CTSB,CXCR4,DAB2,DBN1,DHX29,DHX9,DIAPH2,DIAPH2-AS1,DLAT,DLG1,DMD,DMXL2,DUS1L,DVL1,EHBP1L1,EIF2S1,EIF5B,ENOX2,EPS15,EXT2,EZR,FAS,FNBP1,FOXN3,GAS7,GLS,GLTP,GNA13,GNB5,GPD1L,GPN1,GTPBP8,HADH,HAUS5,HBB,HES1,HIF1AN,HIGD1B,HIST1H2BL,HK1,HNRNPC,HUWE1,ICOSLG,IDH3G,IDS,IGHM,IGK,IGKC,IL13RA1,IL1RAP,ING3,INO80D,INSIG1,IPO8,ITGB1,ITGB3,JUP,KCNE1,KDM5A,KHDC4,KIF2A,KLHL22,KLHL7,KRT5,LAMP1,LDLR,LILRA5,LRBA,LRRFIP2,MAN1A2,MAP4K5,MAP9,MAPKAPK2,MAU2,MDM2,MEF2D,MFNG,MFSD6,MGMT,MLX,MORC3,MPHOSPH9,MPP6,MRPS18B,MSL1,MTMR1,MTMR10,MXRA7,N4BP2L2,NCKIPSD,NEK1,NF2,NIF3L1,NME6,NOP14,NR3C1,NUP88,OPA1,ORC5L,OTUB1,OTUD3,OTUD4,PAK2,PANK3,PARVB,PDHB,PDLIM5,PEPD,PFAS,PHC1,PHEX,PHF16,PHKB,PHTF1,PIGC,PIK3C3,PIK3R4,PJA2,PKP2,PLCB1,POLG,POP5,PPIL6,PPP2R1B,PPP2R5D,PRCC,PRDM2,PRDX1,PRKACA,PSMD11,PTGIR,PTPN11,PTPN12,PUS3,QTRT1,RAB11B,RAB11FIP2,RCOR3,RIOK3,RNF146,RNF24,RPP25,RPS6KA4,RRBP1,RRM2,RTF1,RUBCNL,SAR1A,SCARB1,SCCPDH,SEMA4D,SF3A2,SFRP1,SIDT1,SIRT5,SIT1,SLC14A2,SLC26A2,SLC35D1,SLC39A8,SLC44A1,SLC7A1,SLCO3A1,SMAD3,SMARCA4,SMC6,SNRPN,SNURF,SNX1,SORD,SRGAP3,SRP72,SSBP2,SSRP1,ST20,STX6,SUMO3,SWAP70,TAB1,TAF6,TBC1D13,TBK1,TCF20,TCF4,TCP11L1,TEX28,TFDP2,TGOLN2,TINF2,TK2,TLR6,TMCO6,TOMM22,TOX4,TRAF3IP3,TRAF5,TRGV5,TTC3,TXLNG,TXNL4A,U2AF2,UBE2G1,UBXN1,UBXN8,UCHL3,VEZF1,WDR1,YLPM1,ZBTB25,ZC3H14,ZC3H15,ZFC3H1,ZNF3,ZNF331,ZNF589,ZNF609,ZNF93 GENE_SYMBOLS AFF4,AGPAT3,AKAP8L,AMMECR1,ANKRD17,AQP3,ARHGAP26,ARHGEF7,ARHGEF9,ARL3,ARL4C,ARNT,ATF7IP,ATP2B4,DMAC2L,ATP6V0A1,ATP8A1,AUTS2,BCL2,BIRC5,BLNK,BRWD1,BTN2A3P,NKAPD1,USB1,PRR14L,C2CD3,CAMSAP1,CASK,CBFA2T2,CBL,CC2D1A,YJU2,CCND2,CCNJ,CD164,CD47,CDC42BPA,CDHR5,CDK4,CDYL,CEBPD,CENPF,CENPN,CES2,CHD4,CHD8,CHST10,CKS1B,CLN8,COPS2,COX11,CTSA,CTSB,CXCR4,DAB2,DBN1,DHX29,DHX9,DIAPH2,DIAPH2-AS1,DLAT,DLG1,DMD,DMXL2,DUS1L,DVL1,EHBP1L1,EIF2S1,EIF5B,ENOX2,EPS15,EXT2,EZR,FAS,FNBP1,FOXN3,GAS7,GLS,GLTP,GNA13,GNB5,GPD1L,GPN1,GTPBP8,HADH,HAUS5,HBB,HES1,HIF1AN,HIGD1B,H2BC13,HK1,HNRNPC,HUWE1,ICOSLG,IDH3G,IDS,IGHM,,IGKC,IL13RA1,IL1RAP,ING3,INO80D,INSIG1,IPO8,ITGB1,ITGB3,JUP,KCNE1,KDM5A,KHDC4,KIF2A,KLHL22,KLHL7,KRT5,LAMP1,LDLR,LILRA5,LRBA,LRRFIP2,MAN1A2,MAP4K5,MAP9,MAPKAPK2,MAU2,MDM2,MEF2D,MFNG,MFSD6,MGMT,MLX,MORC3,MPHOSPH9,PALS2,MRPS18B,MSL1,MTMR1,MTMR10,MXRA7,N4BP2L2,NCKIPSD,NEK1,NF2,NIF3L1,NME6,NOP14,NR3C1,NUP88,OPA1,ORC5,OTUB1,OTUD3,OTUD4,PAK2,PANK3,PARVB,PDHB,PDLIM5,PEPD,PFAS,PHC1,PHEX,JADE3,PHKB,PHTF1,PIGC,PIK3C3,PIK3R4,PJA2,PKP2,PLCB1,POLG,POP5,PPIL6,PPP2R1B,PPP2R5D,PRCC,PRDM2,PRDX1,PRKACA,PSMD11,PTGIR,PTPN11,PTPN12,PUS3,QTRT1,RAB11B,RAB11FIP2,RCOR3,RIOK3,RNF146,RNF24,RPP25,RPS6KA4,RRBP1,RRM2,RTF1,RUBCNL,SAR1A,SCARB1,SCCPDH,SEMA4D,SF3A2,SFRP1,SIDT1,SIRT5,SIT1,SLC14A2,SLC26A2,SLC35D1,SLC39A8,SLC44A1,SLC7A1,SLCO3A1,SMAD3,SMARCA4,SMC6,SNRPN,SNURF,SNX1,SORD,SRGAP3,SRP72,SSBP2,SSRP1,ST20,STX6,SUMO3,SWAP70,TAB1,TAF6,TBC1D13,TBK1,TCF20,TCF4,TCP11L1,TEX28,TFDP2,TGOLN2,TINF2,TK2,TLR6,TMCO6,TOMM22,TOX4,TRAF3IP3,TRAF5,TRGV5,TTC3,TXLNG,TXNL4A,U2AF2,UBE2G1,UBXN1,UBXN8,UCHL3,VEZF1,WDR1,YLPM1,ZBTB25,ZC3H14,ZC3H15,ZFC3H1,ZNF3,ZNF331,ZNF589,ZNF609,ZNF93 FOUNDER_NAMES