STANDARD_NAME	NAKAYA_PBMC_FLUAD_IMUVAC_MALE_AGE_14_27YO_CORRELATED_WITH_HAI_RESPONSE_MF59_ADJUVANTED_AND_NON_1DY_GENES_IN_BTM_M75_POSITIVE
SYSTEMATIC_NAME	M41012
COLLECTION	C7:VAX
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/NAKAYA_PBMC_FLUAD_IMUVAC_MALE_AGE_14_27YO_CORRELATED_WITH_HAI_RESPONSE_MF59_ADJUVANTED_AND_NON_1DY_GENES_IN_BTM_M75_POSITIVE
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes positively correlated with HAI response in peripheral blood mononuclear cell in children (14-27m) (MF59-adjuvanted and non-adjuvanted) after exposure to Fluad/Imuvac , time point 1D. Comment: Genes in BTM M75
DESCRIPTION_FULL	The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old healthy children. MF59 enhanced the magnitude and kinetics of serum antibody titers following vaccination, and induced a greater frequency of vaccine specific, multicytokine-producing CD4(+) T cells. Compared with transcriptional responses to TIV vaccination previously reported in adults, responses to TIV in infants were markedly attenuated, limited to genes regulating antiviral and antigen presentation pathways, and observed only in a subset of vaccinees. In contrast, transcriptional responses to ATIV boost were more homogenous and robust. Interestingly, a day 1 gene signature characteristic of the innate response (antiviral IFN genes, dendritic cell, and monocyte responses) correlated with hemagglutination at day 28. These findings demonstrate that MF59 enhances the magnitude, kinetics, and consistency of the innate and adaptive response to vaccination with the seasonal influenza vaccine during early childhood, and identify potential molecular correlates of antibody responses.
PMID	26755593
GEOID	
AUTHORS	Nakaya HI,Clutterbuck E,Kazmin D,Wang L,Cortese M,Bosinger SE,Patel NB,Zak DE,Aderem A,Dong T,Del Giudice G,Rappuoli R,Cerundolo V,Pollard AJ,Pulendran B,Siegrist CA
CONTRIBUTOR	HIPC SIGNATURES
CONTRIBUTOR_ORG	NIAID/HIPC SIGNATURES
EXACT_SOURCE	Fig S7b
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763735/figure/sfig07/
SOURCE_MEMBERS	ANXA3,BCL3,C1QB,CARD9,CXCL10,DDX58,DDX60,DHX58,HERC5,IFIH1,IFIT1,IL1B,IRF7,OAS1,OAS3,PML,RARA,RSAD2,SERPING1
GENE_SYMBOLS	ANXA3,BCL3,C1QB,CARD9,CXCL10,RIGI,DDX60,DHX58,HERC5,IFIH1,IFIT1,IL1B,IRF7,OAS1,OAS3,PML,RARA,RSAD2,SERPING1
FOUNDER_NAMES