STANDARD_NAME	NELSON_RESPONSE_TO_ANDROGEN_DN
SYSTEMATIC_NAME	M16830
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/NELSON_RESPONSE_TO_ANDROGEN_DN
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	Genes down-regulated in LNCaP cells (prostate cancer) in response to synthetic androgen R1881 [PubChem=13766].
DESCRIPTION_FULL	The human prostate gland is an important target organ of androgenic hormones. Testosterone and dihydrotestosterone interact with the androgen receptor to regulate vital aspects of prostate growth and function including cellular proliferation, differentiation, apoptosis, metabolism, and secretory activity. Our objective in this study was to characterize the temporal program of transcription that reflects the cellular response to androgens and to identify specific androgen-regulated genes (ARGs) or gene networks that participate in these responses. We used cDNA microarrays representing about 20,000 distinct human genes to profile androgen-responsive transcripts in the LNCaP adenocarcinoma cell line and identified 146 genes with transcript alterations more than 3-fold. Of these, 103 encode proteins with described functional roles, and 43 represent transcripts that have yet to be characterized. Temporal gene expression profiles grouped the ARGs into four distinct cohorts. Five uncharacterized ARGs demonstrated exclusive or high expression levels in the prostate relative to other tissues studied. A search of available DNA sequence upstream of 28 ARGs identified 25 with homology to the androgen response-element consensus-binding motif. These results identify previously uncharacterized and unsuspected genes whose expression levels are directly or indirectly regulated by androgens; further, they provide a comprehensive temporal view of the transcriptional program of human androgen-responsive cells.
PMID	12185249
GEOID	
AUTHORS	Nelson PS,Clegg N,Arnold H,Ferguson C,Bonham M,White J,Hood L,Lin B
CONTRIBUTOR	Pablo Tamayo
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	Hs.139033,NM_000055,NM_000465,NM_000790,NM_001038,NM_001260,NM_001328,NM_001383,NM_002026,NM_002467,NM_002742,NM_002999,NM_003629,NM_004955,NM_005025,NM_005941,NM_018412,NM_020245,XM_051522
GENE_SYMBOLS	,BCHE,BARD1,DDC,SCNN1A,CDK8,CTBP1,DPH1,FN1,MYC,PRKD1,SDC4,PIK3R3,SLC29A1,SERPINI1,MMP16,ST7,TULP4,
FOUNDER_NAMES