STANDARD_NAME NOUSHMEHR_GBM_GERMLINE_MUTATED SYSTEMATIC_NAME M2090 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/NOUSHMEHR_GBM_GERMLINE_MUTATED NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes with significantl germline mutation differences in proneural G-CIMP (a CpG island methylator phenotype) GBM (glyoblastoma multiforme) tumors. DESCRIPTION_FULL We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds. PMID 20399149 GEOID AUTHORS Noushmehr H,Weisenberger DJ,Diefes K,Phillips HS,Pujara K,Berman BP,Pan F,Pelloski CE,Sulman EP,Bhat KP,Verhaak RG,Hoadley KA,Hayes DN,Perou CM,Schmidt HK,Ding L,Wilson RK,Van Den Berg D,Shen H,Bengtsson H,Neuvial P,Cope LM,Buckley J,Herman JG,Baylin SB,Laird PW,Aldape K,Cancer Genome Atlas Research Network CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2S: GERMLINE, fisher.exact < 0.05 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ASCL2,CDH19,CHAT,DGKZ,KCNV2,LOC389458,PIP5K2A,SOX13 GENE_SYMBOLS ASCL2,CDH19,CHAT,DGKZ,KCNV2,RBAKDN,PIP4K2A,SOX13 FOUNDER_NAMES