STANDARD_NAME	NOUSHMEHR_GBM_SOMATIC_MUTATED
SYSTEMATIC_NAME	M2089
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/NOUSHMEHR_GBM_SOMATIC_MUTATED
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes showing significantly elevated somatic mutation frequencies in proneural G-CIMP (a CpG island methylator phenotype) GBM (glyoblastoma multiforme) tumors.
DESCRIPTION_FULL	We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds.
PMID	20399149
GEOID	
AUTHORS	Noushmehr H,Weisenberger DJ,Diefes K,Phillips HS,Pujara K,Berman BP,Pan F,Pelloski CE,Sulman EP,Bhat KP,Verhaak RG,Hoadley KA,Hayes DN,Perou CM,Schmidt HK,Ding L,Wilson RK,Van Den Berg D,Shen H,Bengtsson H,Neuvial P,Cope LM,Buckley J,Herman JG,Baylin SB,Laird PW,Aldape K,Cancer Genome Atlas Research Network
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2S: SOMATIC, fisher.exact < 0.05
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	DST,EIF2AK4,EPHB4,FGFR4,IDH1,LEMD3,MAPK7,TNFRSF10A,TRPM3
GENE_SYMBOLS	DST,EIF2AK4,EPHB4,FGFR4,IDH1,LEMD3,MAPK7,TNFRSF10A,TRPM3
FOUNDER_NAMES