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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="NOUSHMEHR_GBM_SOMATIC_MUTATED" SYSTEMATIC_NAME="M2089" HISTORICAL_NAMES="" PMID="20399149" AUTHORS="Noushmehr H,Weisenberger DJ,Diefes K,Phillips HS,Pujara K,Berman BP,Pan F,Pelloski CE,Sulman EP,Bhat KP,Verhaak RG,Hoadley KA,Hayes DN,Perou CM,Schmidt HK,Ding L,Wilson RK,Van Den Berg D,Shen H,Bengtsson H,Neuvial P,Cope LM,Buckley J,Herman JG,Baylin SB,Laird PW,Aldape K,Cancer Genome Atlas Research Network" GEOID="" EXACT_SOURCE="Table 2S: SOMATIC, fisher.exact &lt; 0.05" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes showing significantly elevated somatic mutation frequencies in proneural G-CIMP (a CpG island methylator phenotype) GBM (glyoblastoma multiforme) tumors." DESCRIPTION_FULL="We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds." TAGS="" MEMBERS="DST,EIF2AK4,EPHB4,FGFR4,IDH1,LEMD3,MAPK7,TNFRSF10A,TRPM3" MEMBERS_SYMBOLIZED="DST,EIF2AK4,EPHB4,FGFR4,IDH1,LEMD3,MAPK7,TNFRSF10A,TRPM3" MEMBERS_EZID="2050,2264,23592,3417,440275,5598,667,80036,8797" MEMBERS_MAPPING="DST,DST,667|EIF2AK4,EIF2AK4,440275|EPHB4,EPHB4,2050|FGFR4,FGFR4,2264|IDH1,IDH1,3417|LEMD3,LEMD3,23592|MAPK7,MAPK7,5598|TNFRSF10A,TNFRSF10A,8797|TRPM3,TRPM3,80036" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
