STANDARD_NAME ODONNELL_TFRC_TARGETS_DN SYSTEMATIC_NAME M6451 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/ODONNELL_TFRC_TARGETS_DN NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes down-regulated in P493-6 cells (B lymphocyte, Burkitt's lymphoma model) upon knockdown of TFRC [GeneID=7037] by RNAi. DESCRIPTION_FULL Overexpression of transferrin receptor 1 (TFRC1), a major mediator of iron uptake in mammalian cells, is a common feature of human malignancies. Therapeutic strategies designed to interfere with tumor iron metabolism have targeted TFRC1. The c-Myc oncogenic transcription factor stimulates proliferation and growth by activating thousands of target genes. Here we demonstrate that TFRC1 is a critical downstream target of c-Myc. Using in vitro and in vivo models of B-cell lymphoma, we show that TFRC1 expression is activated by c-Myc. Chromatin immunoprecipitation experiments reveal that c-Myc directly binds a conserved region of TFRC1. In light of these findings, we sought to determine whether TFRC1 is required for c-Myc-mediated cellular proliferation and cell size control. TFRC1 inhibition decreases cellular proliferation and results in G1 arrest without affecting cell size. Consistent with these findings, expression profiling reveals that TFRC1 depletion alters expression of genes that regulate the cell cycle. Furthermore, enforced TFRC1 expression confers a growth advantage to cells and significantly enhances the rate of c-Myc-mediated tumor formation in vivo. These findings provide a molecular basis for increased TFRC1 expression in human tumors, illuminate the role of TFRC1 in the c-Myc target gene network, and support strategies that target TFRC1 for cancer therapy. PMID 16508012 GEOID AUTHORS O'Donnell KA,Yu D,Zeller KI,Kim JW,Racke F,Thomas-Tikhonenko A,Dang CV CONTRIBUTOR Leona Saunders CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 7AS: fold change < -2 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1552619_a_at,1553528_a_at,1553727_at,1553822_at,1554060_s_at,1554842_at,1555413_s_at,1555758_a_at,1556117_at,1556821_x_at,1558320_at,1558410_s_at,1558876_at,1559548_at,1561004_at,1562921_at,1563229_at,1563344_at,1564620_at,1564757_a_at,1565717_s_at,1566109_at,1566816_at,1568640_at,201291_s_at,201292_at,201710_at,201897_s_at,202095_s_at,202240_at,202482_x_at,202580_x_at,202615_at,202652_at,202870_s_at,203213_at,203214_x_at,203418_at,203755_at,203764_at,203798_s_at,203968_s_at,203976_s_at,204092_s_at,204162_at,204244_s_at,204306_s_at,204318_s_at,204444_at,204492_at,204560_at,204822_at,204936_at,204962_s_at,205046_at,205909_at,206098_at,206364_at,207165_at,207332_s_at,207382_at,207479_at,207523_at,207828_s_at,208079_s_at,208479_at,208506_at,208580_x_at,208691_at,209053_s_at,209172_s_at,209464_at,209642_at,209714_s_at,209773_s_at,209891_at,209955_s_at,210334_x_at,210408_s_at,210521_s_at,210559_s_at,210683_at,210920_x_at,211088_s_at,211708_s_at,212022_s_at,212023_s_at,212919_at,212949_at,213226_at,213647_at,214020_x_at,214295_at,214349_at,214358_at,214710_s_at,214727_at,215509_s_at,215907_at,216921_s_at,217448_s_at,217646_at,218009_s_at,218247_s_at,218294_s_at,218308_at,218355_at,218542_at,218755_at,219493_at,219494_at,219650_at,219787_s_at,219918_s_at,220295_x_at,220891_at,220895_at,221326_s_at,222342_at,222958_s_at,223624_at,223700_at,224352_s_at,224354_at,224496_s_at,224663_s_at,224704_at,224705_s_at,225687_at,225735_at,225762_x_at,225834_at,225911_at,226821_at,226980_at,227279_at,227350_at,227921_at,228362_s_at,228535_at,228729_at,229349_at,229610_at,229795_at,229996_s_at,230165_at,230543_at,231091_x_at,231128_at,231537_at,231633_at,231722_at,231953_at,232278_s_at,232285_at,232596_at,232850_at,232889_at,233037_at,233147_at,233677_at,234027_at,234789_at,234798_x_at,234863_x_at,234992_x_at,235088_at,235268_at,235363_at,235375_x_at,235490_at,235545_at,235573_at,236040_at,236191_at,236641_at,237215_s_at,237268_at,237543_at,237731_at,238342_at,238433_at,238506_at,238529_at,238704_at,239224_at,239835_at,239973_at,240160_x_at,240434_at,240775_at,241082_at,241617_x_at,241838_at,242054_s_at,242560_at,242734_x_at,242890_at,243239_at,243602_at,244396_at,45633_at GENE_SYMBOLS ANLN,TAF5,B4GALNT3,RTP1,SETMAR,SLC12A1,FBXL21P,CDKN3,,,,,MIR4435-2HG,ACVR2B,PRKCQ-AS1,,DLEU2,ZNF628-DT,,CCDC148,FUS,,FGF22,PCBP1-AS1,TOP2A,TOP2A,MYBL2,CKS1B,BIRC5,PLK1,RANBP1,FOXM1,GNAQ,APBB1,CDC20,CDK1,CDK1,CCNA2,BUB1B,DLGAP5,VSNL1,CDC6,CHAF1A,AURKA,NDC80,DBF4,CD151,GTSE1,KIF11,ARHGAP11A,FKBP5,TTK,MAP4K2,CENPA,CENPE,POLE2,ZBTB6,KIF14,HMMR,TFRC,TP63,,TSBP1,CENPF,AURKA,KCNA1,H3C7,H4C12,TFRC,NSD2,CENPF,AURKB,BUB1,CDKN3,RRM2,SPC25,FAP,BIRC5,CPNE6,FETUB,CDK1,NRTN,,PLK4,SCD,MKI67,MKI67,DCP2,NCAPH,CCNA2,DNA2,,NFIA,ENSG00000275616,ACACA,CCNB1,BRCA2,BUB1,,KRT35,TOX4,SURF1,PRC1,MEX3C,NUP50,TACC3,KIF4A,CEP55,KIF20A,SHCBP1,RAD54B,ERCC6L,ECT2,ASPM,DEPDC1,,USP29,TUBD1,,DEPDC1,ZFAND4,MND1,CFL2,,TMEM107,CFL2,TNRC6A,TNRC6A,FAM83D,ANKRD50,,FAM72C,NPNT,RIF1,DEPDC1B,TCEAL3,HELLS,ENSG00000280018,,RAD1,CCNB1,LIN28B,CKAP2L,MON2,,SGO2,,,FAM181B,,,CASP14,BPTF,DEPDC1,,DIAPH3,,,,,,ITPRID1,,,FBXO5,ECT2,C4orf46,TADA2A,,TTC9B,TMEM107,DEPDC1,HSPH1,XAGE3,,KIF14,TFRC,DSCAM,TBC1D8-AS1,LINC01010,,,LRRC58,,,FBXL20,KBTBD8,SNHG26,SMYD3-IT1,,,,,MIR3939,SIX3,FANCD2,GALT,HELLS,SAMM50,,G3BP1,GINS3 FOUNDER_NAMES