STANDARD_NAME	OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN
SYSTEMATIC_NAME	M10336
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN
NAMESPACE	AFFY_HuGene
DESCRIPTION_BRIEF	Genes down-regulated in epithelial ovarian cancer (EOC) biopsies: invasive (TOV) vs low malignant potential (LMP) tumors.
DESCRIPTION_FULL	Tumors of low malignant potential (LMP) represent 20% of epithelial ovarian cancers (EOCs) and are associated with a better prognosis than the invasive tumors (TOV). Defining the relationship between LMPs and TOVs remains an important goal towards understanding the molecular pathways that contribute to prognosis, as well as providing molecular markers, for these EOCs. To this end, DNA microarray analyses were performed either in a primary culture or a tumor tissue model system and selected candidate genes showing a distinctive expression profile between LMPs and TOVs were identified using a class prediction approach based on three statistical methods of analysis. Both model systems appear relevant as candidate genes identified by either model allowed the proper reclassification of samples as either LMPs or TOVs. Selected candidate genes (CAS, CCNE1, LGALS8, ITGbeta3, ATP1B1, FLIP, KRT7 and KRT19) were validated by real-time quantitative PCR analysis and show differential expression between LMPs and TOVs. Immunohistochemistry analyses showed that the two tumor classes were distinguishable by their expression of CAS, TNFR1A, FLIP, CKS1 and CCNE1. These results define signature patterns for gene expression of LMPs and TOVs and identify gene candidates that warrant further study to deepen our understanding of the biology of EOC.
PMID	15940270
GEOID	
AUTHORS	Ouellet V,Provencher DM,Maugard CM,Le Page C,Ren F,Lussier C,Novak J,Ge B,Hudson TJ,Tonin PN,Mes-Masson AM
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 4S: Pgc > 0
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	D78134_at,HG721-HT4828_s_at,L78132_at,M65292_s_at,M69013_at,S70348_at,U14973_at,U26648_at,U68019_at,U69126_s_at,X07438_s_at,X83543_at,Z49878_at
GENE_SYMBOLS	CIRBP,,LGALS8,CFH,GNA11,ITGB3,RPS29,STX5,SMAD3,KHSRP,RBP1,SHROOM2,GAMT
FOUNDER_NAMES