STANDARD_NAME	OVSYANNIKOVA_PBMC_FLUARIX_AGE_55_64YO_RESPONDERS_VS_NONRESPONDERS_28DY_UP
SYSTEMATIC_NAME	M40906
COLLECTION	C7:VAX
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/OVSYANNIKOVA_PBMC_FLUARIX_AGE_55_64YO_RESPONDERS_VS_NONRESPONDERS_28DY_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in peripheral blood mononuclear cell responders vs nonresponders in adults (55-64) after exposure to Fluarix , time point 28D. Comment: Gene expression related to HAI response
DESCRIPTION_FULL	To assess gene signatures related to humoral response among healthy older subjects following seasonal influenza vaccination, we studied 94 healthy adults (50-74 years old) who received one documented dose of licensed trivalent influenza vaccine containing the A/California/7/2009 (H1N1)-like virus strain. Influenza-specific antibody (HAI) titer in serum samples and next-generation sequencing on PBMCs were performed using blood samples collected prior to (Day 0) and at two timepoints after (Days 3 and 28) vaccination. We identified a number of uncharacterized genes (ZNF300, NUP1333, KLK1 and others) and confirmed previous studies demonstrating specific genes/genesets that are important mediators of host immune responses and that displayed associations with antibody response to influenza A/H1N1 vaccine. These included interferon-regulatory transcription factors (IRF1/IRF2/IRF6/IRF7/IRF9), chemokine/chemokine receptors (CCR5/CCR9/CCL5), cytokine/cytokine receptors (IFNG/IL10RA/TNFRSF1A), protein kinases (MAP2K4/MAPK3), growth factor receptor (TGFBR1). The identification of gene signatures associated with antibody response represents an early stage in the science for which further research is needed. Such research may assist in the design of better vaccines to facilitate improved defenses against new influenza virus strains, as well as better understanding the genetic drivers of immune responses.
PMID	27441275
GEOID	
AUTHORS	Ovsyannikova IG,Oberg AL,Kennedy RB,Zimmermann MT,Haralambieva IH,Goergen KM,Grill DE,Poland GA
CONTRIBUTOR	HIPC SIGNATURES
CONTRIBUTOR_ORG	NIAID/HIPC SIGNATURES
EXACT_SOURCE	Suppl Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946173/bin/mmc1.docx
SOURCE_MEMBERS	ARHGEF10,ATP13A4,CUL1,GRPEL2,KAT2B,MBTPS1,MIR155HG,PHF2,SCRIB
GENE_SYMBOLS	ARHGEF10,ATP13A4,CUL1,GRPEL2,KAT2B,MBTPS1,MIR155HG,PHF2,SCRIB
FOUNDER_NAMES