STANDARD_NAME P53_DN.V1_DN SYSTEMATIC_NAME M2697 COLLECTION C6 MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/P53_DN.V1_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. DESCRIPTION_FULL We examined gene expression patterns from the NCI-60 collection of cancer cell lines. We sought to use these data to identify targets of the transcription factor p53, which regulates gene expression in response to various signals of cellular stress. The mutational status of the p53 gene has been reported for 50 of the NCI-60 cell lines, with 17 being classified as normal and 33 as carrying mutations in the gene. PMID 16199517 GEOID AUTHORS Subramanian A,Tamayo P,Mootha VK,Mukherjee S,Ebert BL,Gillette MA,Paulovich A,Pomeroy SL,Golub TR,Lander ES,Mesirov JP CONTRIBUTOR Pablo Tamayo CONTRIBUTOR_ORG Broad Institute EXACT_SOURCE p53 mutant vs wt panel of NCI-60 cell lines; bottom 200 genes (diff. of means) FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1478_at,1629_s_at,1818_at,33538_at,33721_at,34843_at,35248_at,696_at,728_at,936_s_at,ABCA4,ABCB1 /// ABCB4,ACADS,ACP5,ACTA2,ADA,ADAM23,ADCY1,ADFP,ADRA2C,AKR1B1,ALDH1A1,ANKRD15,APOC1,APOC2,ARHGEF10,ARMC2,ARNT2,BASP1,BAX,BCHE,BCL2A1,BEXL1,BTG2,CA12,CA2,CAPN3,CART1,CASP1,CBX4,CD1D,CD3Z,CDH1,CDH19,CDKN1A,CHGA,CHL1,CHS1,COLEC10,CPS1,CPVL,CRYAB,CSPG2,CTSK,CTSL,CTSZ,CXCL1,CYFIP2,CYP27A1,DCT,DDB2,DDX3Y,DFNA5,DOCK2,ECM1,ELOVL2,EPB41L3,ESM1,FABP5,FAM50B,FBLN5,FDXR,FGB,FGG,FRMD4B,FXYD2,GAL3ST1,GAMT,GAPDS,GAS7,GBA,GFRA1,GGTL4 /// GGT1,GLDC,GLS,GPNMB,GPR143,GPRC5B,GREB1,HGD,HMOX1,HOM-TES-103,HOXB2,HSPA12A,HSPA2,IF,IFI16,IGFBP2,IGFBP7,IL1R1,IL2RB,IRF4,ITGA4,ITGAL,KCNAB2,KCNJ8,KIAA0711,KIAA1201,L1CAM,LAT,LOC146712,LOC201229,LY96,MAL,MATK,MGLL,MIA,MITF,MLANA,MMP7,MTUS1,MYO5A,MYOM2,NAV3,NCALD,NDN,NEF3,NEFL,NID,NINJ1,NP25,NR4A1,NR4A3,NRCAM,NRP2,OAS1,OCA2,PBEF1,PDE1A,PDE4B,PLA2G4A,PLCB4,PLXNC1,PPM1D,PRAME,PRG1,PTPN13,PTPRM,QPCT,RAD51C,RASSF2,RENBP,RFPL3 /// RFPL1 /// RFPL2,RGS20,RHOQ,RPS4Y1,RUNX3,S100A1,S100B,SGK,SHREW1,SIAT10,SIAT8A,SIAT9,SILV,SLC16A4,SLC26A2,SLC26A4,SLC39A6,SLC6A15,SNURF /// SNRPN,SOCS3,SOX10,SOX4,SPG20,SPP1,STAT4,STAT6,STOM,TDRD3,TENC1,TFPI2,THBD,TM4SF2,TM4SF4,TM7SF1,TMEM28,TMEM5,TNFRSF6,TNFSF9,TP53AP1,TRIM22,TRIM38,TYR,UGT2B7,VGF,VIM,VLDLR,VPS41,ZFYVE16 GENE_SYMBOLS ITK,PTPN13,RHOQ,SLC24A5,ABCC2,ZNF516,SLC19A2,HOXD8,LAMA1,NSG1,ABCA4,,ACADS,ACP5,ACTA2,ADA,ADAM23,ADCY1,PLIN2,ADRA2C,AKR1B1,ALDH1A1,KANK1,APOC1,APOC2,ARHGEF10,ARMC2,ARNT2,BASP1,BAX,BCHE,BCL2A1,BEX4,BTG2,CA12,CA2,CAPN3,ALX1,CASP1,CBX4,CD1D,CD247,CDH1,CDH19,CDKN1A,CHGA,CHL1,LYST,COLEC10,CPS1,CPVL,CRYAB,VCAN,CTSK,CTSL,CTSZ,CXCL1,CYFIP2,CYP27A1,DCT,DDB2,DDX3Y,GSDME,DOCK2,ECM1,ELOVL2,EPB41L3,ESM1,FABP5,FAM50B,FBLN5,FDXR,FGB,FGG,FRMD4B,FXYD2,GAL3ST1,GAMT,GAPDHS,GAS7,GBA1,GFRA1,,GLDC,GLS,GPNMB,GPR143,GPRC5B,GREB1,HGD,HMOX1,IFFO1,HOXB2,HSPA12A,HSPA2,CFI,IFI16,IGFBP2,IGFBP7,IL1R1,IL2RB,IRF4,ITGA4,ITGAL,KCNAB2,KCNJ8,KBTBD11,GRAMD1B,L1CAM,LAT,B3GNTL1,LYRM9,LY96,MAL,MATK,MGLL,MIA,MITF,MLANA,MMP7,MTUS1,MYO5A,MYOM2,NAV3,NCALD,NDN,NEFM,NEFL,NID1,NINJ1,TAGLN3,NR4A1,NR4A3,NRCAM,NRP2,OAS1,OCA2,NAMPT,PDE1A,PDE4B,PLA2G4A,PLCB4,PLXNC1,PPM1D,PRAME,SRGN,PTPN13,PTPRM,QPCT,RAD51C,RASSF2,RENBP,,RGS20,RHOQ,RPS4Y1,RUNX3,S100A1,S100B,SGK1,AJAP1,ST3GAL6,ST8SIA1,ST3GAL5,PMEL,SLC16A4,SLC26A2,SLC26A4,SLC39A6,SLC6A15,,SOCS3,SOX10,SOX4,SPART,SPP1,STAT4,STAT6,STOM,TDRD3,TNS2,TFPI2,THBD,TSPAN7,TM4SF4,GPR137B,NALF2,RXYLT1,FAS,TNFSF9,TP53TG1,TRIM22,TRIM38,TYR,UGT2B7,VGF,VIM,VLDLR,VPS41,ZFYVE16 FOUNDER_NAMES