STANDARD_NAME PEREZ_TP53_AND_TP63_TARGETS SYSTEMATIC_NAME M14566 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/PEREZ_TP53_AND_TP63_TARGETS NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes up-regulated in HMEC cells (primary mammary epithelium) upon expression of both of TP53 [GeneID=7157] and the transcriptionally active isoform of TP63 [GeneID=8626] off adenoviral vectors. DESCRIPTION_FULL p53 and p63 belong to a family of sequence-specific transcription factors regulating key cellular processes. Differential composition of the p53 and p63 DNA-binding sites may contribute to distinct functions of these protein homologues. We used SELEX (systematic evolution of ligands by exponential enrichment) methodology to identify nucleic acid ligands for p63. We found that p63 bound preferentially to DNA fragments conforming to the 20 bp sequence 5'-RRRC(A/G)(A/T)GYYYRRRC(A/T)(C/T)GYYY-3'. Relative to the p53 consensus, the p63 consensus DNA-binding site (DBS) was more degenerate, particularly at positions 10 and 11, and was enriched for A/G at position 5 and C/T at position 16 of the consensus. The differences in DNA-binding site preferences between p63 and p53 influenced their ability to activate transcription from select response elements (REs) in cells. A computer algorithm, p63MH, was developed to find candidate p63-binding motifs on input sequences. We identified genes responsive to p63 regulation that contain functional p63 REs. Our results suggest that the sequence composition of REs could be one contributing factor to target gene discrimination between p63 and p53. PMID 17563751 GEOID AUTHORS Perez CA,Ott J,Mays DJ,Pietenpol JA CONTRIBUTOR Leona Saunders CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 4S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1438_at,1553528_a_at,1553986_at,1554474_a_at,1554690_a_at,1555310_a_at,1555372_at,1555862_s_at,1555935_s_at,1556545_at,1557270_at,1557539_at,1557636_a_at,1558143_a_at,1558401_at,1559051_s_at,1559600_at,1561341_at,1568623_a_at,1568780_at,1569607_s_at,1569608_x_at,200884_at,201427_s_at,201565_s_at,201566_x_at,201693_s_at,201694_s_at,202086_at,202156_s_at,202157_s_at,202158_s_at,202179_at,202409_at,202481_at,203068_at,203238_s_at,203304_at,203528_at,203627_at,203747_at,203756_at,203921_at,203946_s_at,204072_s_at,204130_at,204254_s_at,204255_s_at,204364_s_at,204396_s_at,204451_at,204452_s_at,204503_at,204529_s_at,204537_s_at,204538_x_at,204548_at,204589_at,204684_at,204724_s_at,204790_at,204859_s_at,205110_s_at,205125_at,205249_at,205290_s_at,205320_at,205493_s_at,205559_s_at,205560_at,205590_at,205780_at,205807_s_at,205858_at,205935_at,205952_at,206157_at,206276_at,206363_at,206377_at,206710_s_at,207069_s_at,207144_s_at,207571_x_at,208763_s_at,209081_s_at,209283_at,209291_at,209333_at,209539_at,209596_at,209631_s_at,209652_s_at,209691_s_at,209897_s_at,209907_s_at,210086_at,210095_s_at,210130_s_at,210239_at,210387_at,210426_x_at,210479_s_at,210654_at,210944_s_at,211226_at,211421_s_at,211554_s_at,211824_x_at,212099_at,212143_s_at,212230_at,212419_at,212423_at,212430_at,212599_at,212812_at,212964_at,212966_at,213182_x_at,213212_x_at,213236_at,213245_at,213256_at,213348_at,213766_x_at,213792_s_at,214475_x_at,215921_at,216347_s_at,216894_x_at,217437_s_at,217681_at,218002_s_at,218559_s_at,218723_s_at,218736_s_at,218900_at,218918_at,219332_at,219358_s_at,219433_at,219461_at,219534_x_at,219681_s_at,219694_at,219995_s_at,220161_s_at,220220_at,220306_at,221011_s_at,221012_s_at,221348_at,221501_x_at,221541_at,221552_at,221679_s_at,221805_at,221887_s_at,221901_at,222484_s_at,222670_s_at,222725_s_at,222820_at,223129_x_at,223130_s_at,223322_at,223378_at,223387_at,223427_s_at,223494_at,223566_s_at,223642_at,224839_s_at,225056_at,225172_at,225263_at,225288_at,225292_at,225293_at,225372_at,225373_at,225434_at,225457_s_at,225458_at,225564_at,225606_at,225739_at,225817_at,225867_at,225955_at,226111_s_at,226114_at,226208_at,226450_at,226499_at,226612_at,226682_at,226811_at,226869_at,226899_at,226913_s_at,227120_at,227345_at,227396_at,227404_s_at,227410_at,227432_s_at,227480_at,227481_at,227719_at,227816_at,227923_at,228010_at,228098_s_at,228409_at,228549_at,228550_at,228613_at,229297_at,229358_at,229377_at,229622_at,230130_at,230712_at,231382_at,231930_at,231969_at,232116_at,232165_at,232289_at,232773_at,233198_at,233550_s_at,233587_s_at,234317_s_at,235119_at,235144_at,235230_at,235238_at,235252_at,235302_at,235868_at,236045_x_at,236266_at,236379_at,237899_at,238029_s_at,238043_at,238066_at,238542_at,238692_at,238878_at,239312_at,239355_at,239537_at,240157_at,240180_at,241233_x_at,242204_at,242463_x_at,242517_at,242931_at,243173_at,243386_at,244321_at,39248_at,39249_at,41577_at,43511_s_at,45288_at,47553_at,823_at GENE_SYMBOLS EPHB3,TAF5,RASEF,MOXD1,TACC1,PAK6,,MICALL2,HUNK,,,,C7orf57,BCL2L11,ARIH1,CGAS,,,SLC35E4,,ANKRD20A1,,CKB,SELENOP,ID2,,EGR1,EGR1,MX1,CELF2,CELF2,CELF2,BLMH,IGF2,DHRS3,KLHL21,NOTCH3,BAMBI,SEMA4D,IGF1R,AQP3,ARHGEF17,CHST2,ARG2,FRY,HSD11B2,VDR,VDR,REEP1,GRK5,FZD1,FZD1,EVPL,TOX,GABRE,NPIPA1,STAR,NUAK1,NPTX1,COL9A3,SMAD7,APAF1,FGF13,PLCD1,,BMP2,APC2,DPYSL4,PCSK5,PCSK5,RASGRP1,BIK,TUFT1,NGFR,FOXF1,KCNK3,PTX3,LY6D,MAF,FOXF2,EPB41L3,SMAD6,CITED1,THEMIS2,TSC22D3,COL18A1,CRYAB,ID4,ULK1,ARHGEF6,MXRA5,GPR37,PGF,DOK4,SLIT2,ITSN2,HR,IGFBP3,TM7SF2,IRX5,,RORA,RORA,TNFRSF10D,CAPN3,GALR2,RET,APAF1,NLRP1,RHOB,IGFBP3,PLPP3,ZCCHC24,ZCCHC24,RBM38,AUTS2,SERINC5,HIC2,HIC2,CDKN1C,GOLGA6L9,SASH1,ADCY1,MARCHF3,CDKN1C,GNA11,INSR,CAPN3,NPIPB3,PPP1R13B,CDKN1C,TACC1,WNT7B,CXCL14,MAFB,RGCC,PALMD,CNNM4,MAN1C1,MICALL2,ADAP2,BCOR,PAK6,CDKN1C,RAB11FIP1,OTULINL,ZNF750,EPB41L4B,LRRC37A4P,TENT5C,LBH,TRIM8,NPPC,NPIPA1,CRISPLD2,ABHD6,ABHD6,NEFL,WHRN,SHISAL1,CXCL14,MAFB,PALMD,TNRC6C,MYLIP,MYLIP,RASSF5,GLIS2,ZFYVE1,EPB41L4B,OGA,BCOR,ZIC2,GPT2,SIPA1L2,CRAMP1,HS6ST1,COL27A1,COL27A1,COL27A1,VSIR,VSIR,DEDD2,SLC9A3,SLC9A3,SPATA13,BCL2L11,RAB11FIP4,CGNL1,VASN,METRNL,ZNF385A,ZNF436,ZSWIM6,INSR,NRARP,UBE2QL1,RORA,TENT5C,MEGF6,UNC5B,SOX8,FOXP4,TNFRSF10D,PTPRJ,,FAM43A,,SUSD2,CNKSR3,SMAD9,NTN1,SHANK3,PPP2R2C,MYLIP,PLIN4,,RTN4R,RAB11FIP3,GPATCH2L,IHH,GRTP1,ERFE,,,FGF18,ELMOD1,STOX2,GRHL3,EPPK1,KCNJ12,,GOLGA2P5,SLC4A11,SIPA1L2,STOX2,TAF3,RASEF,PLCXD2,SHC4,KSR1,GPATCH2L,,DOC2B,RORA,EPB41,EDDM13,SLC16A14,ARID1B,RBP7,ULBP2,ABTB3,ARX,,GMCL1,ST8SIA2,,MAP7,ANKRD20A11P,WFDC5,ZNF600,KISS1R,,CABP7,CASZ1,PGAP1,AQP3,AQP3,PPP1R16B,ARRB1,ABHD6,WHRN,CX3CL1 FOUNDER_NAMES