STANDARD_NAME	PETRETTO_LEFT_VENTRICLE_MASS_QTL_CIS_DN
SYSTEMATIC_NAME	M1382
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/PETRETTO_LEFT_VENTRICLE_MASS_QTL_CIS_DN
NAMESPACE	AFFY_Rat230
DESCRIPTION_BRIEF	Down-regulated cis-regulated expression quantitative loci (cis-eQTL) in the heart that were identified as candidate genes for the regulation of left ventricle mass (LVM).
DESCRIPTION_FULL	Left ventricular mass (LVM) and cardiac gene expression are complex traits regulated by factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we combined expression quantitative trait locus1 and quantitative trait transcript (QTT) analyses of the cardiac transcriptome in the rat. Using these methods and in vitro functional assays, we identified osteoglycin (Ogn) as a major candidate regulator of rat LVM, with increased Ogn protein expression associated with elevated LVM. We also applied genome-wide QTT analysis to the human heart and observed that, out of 22,000 transcripts, OGN transcript abundance had the highest correlation with LVM. We further confirmed a role for Ogn in the in vivo regulation of LVM in Ogn knockout mice. Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.
PMID	18443592
GEOID	GSE10161
AUTHORS	Petretto E,Sarwar R,Grieve I,Lu H,Kumaran MK,Muckett PJ,Mangion J,Schroen B,Benson M,Punjabi PP,Prasad SK,Pennell DJ,Kiesewetter C,Tasheva ES,Corpuz LM,Webb MD,Conrad GW,Kurtz TW,Kren V,Fischer J,Hubner N,Pinto YM,Pravenec M,Aitman TJ,Cook SA
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 5S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1373378_at,1376500_at,1377054_at,1379560_at,1380127_at,1382468_at,1383070_at,1383759_at,1384301_at,1388603_a_at,1388613_at,1390126_at,1392699_at,1397740_at
GENE_SYMBOLS	AGTPBP1,TSPAN17,SEMA4D,NSD1,,QNG1,FAF2,AGTPBP1,KLHL3,ISCA1,ISCA1,CENPP,ZNF346,SFXN1
FOUNDER_NAMES