STANDARD_NAME POOLA_INVASIVE_BREAST_CANCER_DN SYSTEMATIC_NAME M6767 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/POOLA_INVASIVE_BREAST_CANCER_DN NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes down-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH). DESCRIPTION_FULL Breast cancer is the second leading cause of cancer death for women in the United States. In 2005, about 215,000 cases of invasive breast cancer (IBC) and 50,000 cases of ductal carcinoma in situ will be diagnosed and 40,000 women will die of IBC in the US. Yet there is presently no molecular marker that can be used to detect a precancerous state or identify which premalignant lesions will develop into invasive breast cancer. Here we report the gene expression analysis of atypical ductal hyperplastic tissues from patients with and without a history of breast cancer. We identify MMP-1 as a candidate marker that may be useful for identification of breast lesions that can develop into cancer. PMID 15864312 GEOID AUTHORS Poola I,DeWitty RL,Marshalleck JJ,Bhatnagar R,Abraham J,Leffall LD CONTRIBUTOR Jessica Robertson CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 201467_s_at,201474_s_at,201641_at,201749_at,201820_at,201860_s_at,202018_s_at,202071_at,202088_at,202089_s_at,202196_s_at,202291_s_at,202350_s_at,202376_at,202555_s_at,202718_at,202888_s_at,203092_at,203223_at,203400_s_at,203421_at,203438_at,203439_s_at,203468_at,203469_s_at,203627_at,203628_at,203697_at,203710_at,203722_at,203815_at,203892_at,203928_x_at,203929_s_at,203951_at,204018_x_at,204029_at,204083_s_at,204272_at,204284_at,204306_s_at,204379_s_at,204422_s_at,204442_x_at,204455_at,204508_s_at,204545_at,204578_at,204596_s_at,204607_at,204712_at,204765_at,204792_s_at,204798_at,204855_at,205029_s_at,205157_s_at,205200_at,205225_at,205337_at,205355_at,205358_at,205376_at,205380_at,205413_at,205430_at,205440_s_at,205463_s_at,205471_s_at,205509_at,205613_at,205696_s_at,205749_at,205767_at,205990_s_at,206315_at,206326_at,206560_s_at,206825_at,207144_s_at,207695_s_at,208399_s_at,208475_at,208607_s_at,208613_s_at,208614_s_at,209116_x_at,209270_at,209309_at,209395_at,209396_s_at,209443_at,209458_x_at,209465_x_at,209466_x_at,209603_at,209792_s_at,210096_at,210108_at,210319_x_at,210729_at,211323_s_at,211682_x_at,211696_x_at,211699_x_at,211737_x_at,211745_x_at,212236_x_at,212239_at,212448_at,212463_at,212496_s_at,212564_at,212730_at,213110_s_at,213425_at,213575_at,213593_s_at,213680_at,213839_at,214053_at,214063_s_at,214247_s_at,214414_x_at,214475_x_at,214802_at,215070_x_at,215071_s_at,215356_at,215397_x_at,215432_at,215473_at,215609_at,215616_s_at,215692_s_at,216331_at,216373_at,216466_at,216650_at,216918_s_at,216944_s_at,217014_s_at,217232_x_at,217414_x_at,218195_at,218720_x_at,218872_at,218976_at,219197_s_at,219255_x_at,219305_x_at,219308_s_at,219359_at,219401_at,219768_at,219876_s_at,219919_s_at,219922_s_at,219932_at,220076_at,220581_at,220858_at,221275_s_at,221646_s_at,221854_at,221920_s_at,222312_s_at,32402_s_at,41660_at GENE_SYMBOLS NQO1,,BST2,ECE1,KRT5,PLAT,LTF,SDC4,SLC39A6,SLC39A6,DKK3,MGP,MATN2,SERPINA3,MYLK,IGFBP2,ANPEP,TIMM44,RABEP1,TF,,STC2,STC2,CDK10,CDK10,IGF1R,IGF1R,FRZB,ITPR1,ALDH4A1,GSTT1,WFDC2,MAPT,MAPT,CNN1,HBA1,CELSR2,TPM2,LGALS4,PPP1R3C,CD151,FGFR3,FGF2,LTBP4,DST,CA12,PEX6,PPIP5K1,STC1,HMGCS2,WIF1,ARHGEF5,IFT140,MYB,,FABP7,KRT17,CLEC3B,ESR1,DCT,ACADSB,GRIA2,INPP4B,PDZK1,MPPED2,BMP5,NPY1R,PDGFA,DACH1,CPB1,SYT17,GFRA1,CYP1A1,EREG,WNT5A,CRLF1,GRP,MIA,OXTR,CITED1,IGSF1,EDN3,FRMD4A,SAA1,FLNB,FLNB,HBB,LAMB3,AZGP1,CHI3L1,CHI3L1,SERPINA5,HBA1,PTN,PTN,GATA3,KLK10,CYP4B1,CACNA1D,MSX2,NPY2R,ITPR1,UGT2B11,HBB,HBA1,PTN,HBA1,KRT17,PIK3R1,NEDD4L,CD59,KDM4B,KCTD2,SYNM,COL4A5,WNT5A,TRA2A,,KRT6B,CLMN,ERBB4,TF,DKK3,HBA1,CAPN3,EXOC7,RABGAP1,H2AC6,TDRD12,,ACSM1,,,KDM4B,MPPED2,ITGA7,TAPT1,,RPL29P17,DST,ITPR1,AZGP1,HBB,HBA1,ARMT1,SEZ6L2,TESC,DNAJC12,SCUBE2,IL17RB,FBXO2,AK5,PGGHG,XYLT2,VTCN1,GOLGA2P5,SSH3,LTBP3,SLC27A6,ANKH,CCDC170,,TMEM101,ZDHHC11,PKP1,SLC25A37,,SYMPK,CELSR1 FOUNDER_NAMES