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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="PRC2_EZH2_UP.V1_DN" SYSTEMATIC_NAME="M2737" HISTORICAL_NAMES="" PMID="16618801" AUTHORS="Bracken AP,Dietrich N,Pasini D,Hansen KH,Helin K" GEOID="GSE6015" EXACT_SOURCE="ko vs control; bottom 200 genes" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Pablo Tamayo" CONTRIBUTOR_ORG="Broad Institute" DESCRIPTION_BRIEF="Genes down-regulated in TIG3 cells (fibroblasts) upon knockdown of EZH2 [Gene ID=2146] gene." DESCRIPTION_FULL="The identification of gene expression changes in human embryonic fibroblast cells depleted of EZH2." TAGS="" MEMBERS="ACTC1,ADAMTS5,ADCK4,AFF3,AGTR1,AIM1L,APLP1,ATG16L1,ATP4B,ATXN8OS,AURKB,BARX1,BCCIP,BUB1,C14orf106,C20orf117,C6orf25,C8orf51,CACNA2D2,CAMK4,CASC3,CD320,CDC25A,CDC45L,CDH17,CDT1,CEBPE,CENPF,CGA,CHES1,CHM,CNGB3,CORO1A,CPEB1,CTBP2 /// LOC645291,CXCL12,CYB5B,CYP3A7,DCC1,DDB2,DDHD2,DEF6,DEPDC1,DEPDC5,DKFZp762E1312,DLG7,DNA2L,DNMT3L,DOC2B,DPY19L4,ECT2,EGFL8 /// LOC653870,ELL2,EPHX2,ETS1,EXOSC8,EZH2,FCN3,FKBP5,FKBP6,FLJ20309,FOSL2,FUT7,GAGE3,GALR3,GAS1,GJA12,GLRA2,GNA15,GNB1L,GRM4,GTPBP4,GUCY1A2,HAS2,HBD,HCFC1R1,HELLS,HIST1H3F,HMMR,HMOX1,HOXA10,HOXD11,HP1BP3,IFIT1,IL17RB,INHBB,IQCC,KCND1,KCNS1,KCTD2,KIAA0841,KIAA2002,KIF15,KIF4A,KLHL11,KNTC1,KRT81,LBR,LEMD3,LGALS7,LIN7A,LINS1,LMNB1,LMOD1,LOC221362,LOC282997,LOC650620,LOC653423,LPGAT1,LRP12,LRRC20,LRRC32,LRRC61,MCM10,MCM2,MED18,MEFV,METT10D,MLF1IP,MRPS18B,MS4A12,MSH5,MST1R,MXD3,MYBL2,MYT1L,NCAPH,NFE2,NFIB,NGFB,NLGN1,NMBR,NPAS1,NPR3,NR6A1,NUP37,NUP43,OCEL1,OIP5,OLFML2B,OXNAD1,OXTR,PAGE4,PARC,PCK2,PCYT1B,PGDS,PILRB,PITX1,PLCD1,PLN,PNOC,POLR3G,PRIM1,PRSS1,PSPH,PSRC1,PTPRD,PUS7,RAD54L,RDH5,RFC4,RNF19,RP6-213H19.1,RPS6KA6,SCN3A,SET /// LOC642869,SIGLEC5,SKP2,SLC16A10,SLC2A6,SLC7A2,SLC8A1,SOAT2,SULF1,SYN1,SYP,SYT11,TACC3,TAF9B /// LOC653068,TBC1D2,TDGF1 /// TDGF3,TFAM,THBS2,THOP1,TM7SF4,TMEM103,TNFSF11,TOX,TPD52L1,TRPM4,TTK,USP52,UTF1,VPS37B,WDR76,XRCC3,ZNF219,ZNF446,ZNF574" MEMBERS_SYMBOLIZED="ACTC1,ADAMTS5,AFF3,AGTR1,APLP1,ATG16L1,ATP4B,ATXN8OS,AURKB,BARX1,BCCIP,BUB1,CACNA2D2,CAMK4,CASC3,CCL18,CD320,CDC25A,CDC45,CDH17,CDT1,CEBPE,CENPF,CENPU,CGA,CHM,CNGB3,COQ8B,CORO1A,CPEB1,CRYBG2,CXCL12,CYB5B,CYP3A7,DCSTAMP,DDB2,DDHD2,DEF6,DEPDC1,DEPDC5,DLGAP5,DNA2,DNMT3L,DOC2B,DPY19L4,DSCC1,ECT2,ELL2,ELP6,ENSG00000291006,EPHX2,ETS1,EXOSC8,EZH2,FCN3,FKBP5,FKBP6,FOSL2,FOXN3,FUT7,GALR3,GAS1,GJC2,GLRA2,GNA15,GNB1L,GRM4,GTPBP4,GUCY1A2,H3C7,HAS2,HAUS5,HBD,HCFC1R1,HELLS,HJURP,HMMR,HMOX1,HOXA10,HOXD11,HP1BP3,IFIT1,IL17RB,INHBB,INO80D,IQCC,KCND1,KCNS1,KCTD2,KIF15,KIF4A,KLHL11,KNTC1,KRT81,LBR,LEMD3,LGALS7,LIN7A,LINS1,LMNB1,LMOD1,LPGAT1,LRP12,LRRC20,LRRC32,LRRC61,MCM10,MCM2,MED18,MEFV,METTL16,MIS18BP1,MPIG6B,MRPS18B,MS4A12,MSH5,MST1R,MTCL2,MXD3,MYBL2,MYT1L,NCAPH,NFE2,NFIB,NGF,NLGN1,NMBR,NPAS1,NPR3,NR6A1,NUP37,NUP43,OCEL1,OIP5,OLFML2B,OXNAD1,OXTR,PAGE4,PAN2,PCK2,PCYT1B,PDCD4-AS1,PEAK1,PILRB,PITX1,PLCD1,PLN,PNOC,POLR3G,PRIM1,PRSS1,PSPH,PSRC1,PTGDS,PTPRD,PUS7,RAD54L,RDH5,RFC4,RHPN1-AS1,RNF19A,RPS6KA6,SCN3A,SIGLEC5,SKP2,SLC16A10,SLC2A6,SLC7A2,SLC8A1,SOAT2,SPAG11A,SULF1,SYN1,SYP,SYT11,TACC3,TBC1D2,TFAM,THBS2,THOP1,TNFSF11,TOX,TPD52L1,TRPM4,TTK,UTF1,VPS37B,WDR76,XRCC3,ZNF219,ZNF446,ZNF574" MEMBERS_EZID="1015,10460,1053,10622,1063,1081,11096,1112,11151,11182,1121,11339,11340,117247,140710,1551,1643,1763,185,1894,2053,2113,2146,22794,22871,2289,22936,23040,23208,23213,23259,23354,23397,23510,2355,23560,23592,24137,2529,25802,25897,25903,2615,2619,2649,27330,2742,2769,282997,286148,28973,2914,2977,29947,29967,29990,3037,3045,3070,3161,3162,3206,3237,333,3434,348995,3625,3750,3787,3887,3899,3930,3963,4001,4171,4210,4439,4486,4605,4778,4781,4803,4829,4861,4883,496,5021,50619,50809,5106,51222,51293,5307,5333,5350,5368,54517,54584,54714,54795,54797,54859,54860,54891,54985,55054,55057,55175,55180,55222,55320,55355,55357,55388,55540,5557,55635,55663,55721,56033,5644,56647,56992,57165,5723,5730,5789,5959,5984,6315,6328,6362,6387,64506,64763,6502,653423,6542,6546,65999,6853,6855,699,70,7019,7058,7064,7164,7272,730101,7517,78998,79023,79066,79075,79629,79682,79720,79834,79934,79968,80739,80777,814,81501,81620,8318,83463,8433,8435,8438,8447,8468,84722,8484,8547,8600,8778,8825,8968,92106,9212,9254,9468,9506,9681,9735,9760,9787,9924,9926,993" MEMBERS_MAPPING="ACTC1,ACTC1,70|ADAMTS5,ADAMTS5,11096|ADCK4,COQ8B,79934|AFF3,AFF3,3899|AGTR1,AGTR1,185|AIM1L,CRYBG2,55057|APLP1,APLP1,333|ATG16L1,ATG16L1,55054|ATP4B,ATP4B,496|ATXN8OS,ATXN8OS,6315|AURKB,AURKB,9212|BARX1,BARX1,56033|BCCIP,BCCIP,56647|BUB1,BUB1,699|C14orf106,MIS18BP1,55320|C20orf117,MTCL2,140710|C6orf25,MPIG6B,80739|C8orf51,RHPN1-AS1,78998|CACNA2D2,CACNA2D2,9254|CAMK4,CAMK4,814|CASC3,CASC3,22794|CD320,CD320,51293|CDC25A,CDC25A,993|CDC45L,CDC45,8318|CDH17,CDH17,1015|CDT1,CDT1,81620|CEBPE,CEBPE,1053|CENPF,CENPF,1063|CGA,CGA,1081|CHES1,FOXN3,1112|CHM,CHM,1121|CNGB3,CNGB3,54714|CORO1A,CORO1A,11151|CPEB1,CPEB1,64506|CTBP2 /// LOC645291,null,null|CXCL12,CXCL12,6387|CYB5B,CYB5B,80777|CYP3A7,CYP3A7,1551|DCC1,DSCC1,79075|DDB2,DDB2,1643|DDHD2,DDHD2,23259|DEF6,DEF6,50619|DEPDC1,DEPDC1,55635|DEPDC5,DEPDC5,9681|DKFZp762E1312,HJURP,55355|DLG7,DLGAP5,9787|DNA2L,DNA2,1763|DNMT3L,DNMT3L,29947|DOC2B,DOC2B,8447|DPY19L4,DPY19L4,286148|ECT2,ECT2,1894|EGFL8 /// LOC653870,null,null|ELL2,ELL2,22936|EPHX2,EPHX2,2053|ETS1,ETS1,2113|EXOSC8,EXOSC8,11340|EZH2,EZH2,2146|FCN3,FCN3,8547|FKBP5,FKBP5,2289|FKBP6,FKBP6,8468|FLJ20309,INO80D,54891|FOSL2,FOSL2,2355|FUT7,FUT7,2529|GAGE3,null,null|GALR3,GALR3,8484|GAS1,GAS1,2619|GJA12,GJC2,57165|GLRA2,GLRA2,2742|GNA15,GNA15,2769|GNB1L,GNB1L,54584|GRM4,GRM4,2914|GTPBP4,GTPBP4,23560|GUCY1A2,GUCY1A2,2977|HAS2,HAS2,3037|HBD,HBD,3045|HCFC1R1,HCFC1R1,54985|HELLS,HELLS,3070|HIST1H3F,H3C7,8968|HMMR,HMMR,3161|HMOX1,HMOX1,3162|HOXA10,HOXA10,3206|HOXD11,HOXD11,3237|HP1BP3,HP1BP3,50809|IFIT1,IFIT1,3434|IL17RB,IL17RB,55540|INHBB,INHBB,3625|IQCC,IQCC,55721|KCND1,KCND1,3750|KCNS1,KCNS1,3787|KCTD2,KCTD2,23510|KIAA0841,HAUS5,23354|KIAA2002,PEAK1,79834|KIF15,KIF15,56992|KIF4A,KIF4A,24137|KLHL11,KLHL11,55175|KNTC1,KNTC1,9735|KRT81,KRT81,3887|LBR,LBR,3930|LEMD3,LEMD3,23592|LGALS7,LGALS7,3963|LIN7A,LIN7A,8825|LINS1,LINS1,55180|LMNB1,LMNB1,4001|LMOD1,LMOD1,25802|LOC221362,ENSG00000291006,730101|LOC282997,PDCD4-AS1,282997|LOC650620,null,null|LOC653423,SPAG11A,653423|LPGAT1,LPGAT1,9926|LRP12,LRP12,29967|LRRC20,LRRC20,55222|LRRC32,LRRC32,2615|LRRC61,LRRC61,65999|MCM10,MCM10,55388|MCM2,MCM2,4171|MED18,MED18,54797|MEFV,MEFV,4210|METT10D,METTL16,79066|MLF1IP,CENPU,79682|MRPS18B,MRPS18B,28973|MS4A12,MS4A12,54860|MSH5,MSH5,4439|MST1R,MST1R,4486|MXD3,MXD3,83463|MYBL2,MYBL2,4605|MYT1L,MYT1L,23040|NCAPH,NCAPH,23397|NFE2,NFE2,4778|NFIB,NFIB,4781|NGFB,NGF,4803|NLGN1,NLGN1,22871|NMBR,NMBR,4829|NPAS1,NPAS1,4861|NPR3,NPR3,4883|NR6A1,NR6A1,2649|NUP37,NUP37,79023|NUP43,NUP43,348995|OCEL1,OCEL1,79629|OIP5,OIP5,11339|OLFML2B,OLFML2B,25903|OXNAD1,OXNAD1,92106|OXTR,OXTR,5021|PAGE4,PAGE4,9506|PARC,CCL18,6362|PCK2,PCK2,5106|PCYT1B,PCYT1B,9468|PGDS,PTGDS,5730|PILRB,PILRB,29990|PITX1,PITX1,5307|PLCD1,PLCD1,5333|PLN,PLN,5350|PNOC,PNOC,5368|POLR3G,POLR3G,10622|PRIM1,PRIM1,5557|PRSS1,PRSS1,5644|PSPH,PSPH,5723|PSRC1,PSRC1,84722|PTPRD,PTPRD,5789|PUS7,PUS7,54517|RAD54L,RAD54L,8438|RDH5,RDH5,5959|RFC4,RFC4,5984|RNF19,RNF19A,25897|RP6-213H19.1,null,null|RPS6KA6,RPS6KA6,27330|SCN3A,SCN3A,6328|SET /// LOC642869,null,null|SIGLEC5,SIGLEC5,8778|SKP2,SKP2,6502|SLC16A10,SLC16A10,117247|SLC2A6,SLC2A6,11182|SLC7A2,SLC7A2,6542|SLC8A1,SLC8A1,6546|SOAT2,SOAT2,8435|SULF1,SULF1,23213|SYN1,SYN1,6853|SYP,SYP,6855|SYT11,SYT11,23208|TACC3,TACC3,10460|TAF9B /// LOC653068,null,null|TBC1D2,TBC1D2,55357|TDGF1 /// TDGF3,null,null|TFAM,TFAM,7019|THBS2,THBS2,7058|THOP1,THOP1,7064|TM7SF4,DCSTAMP,81501|TMEM103,ELP6,54859|TNFSF11,TNFSF11,8600|TOX,TOX,9760|TPD52L1,TPD52L1,7164|TRPM4,TRPM4,54795|TTK,TTK,7272|USP52,PAN2,9924|UTF1,UTF1,8433|VPS37B,VPS37B,79720|WDR76,WDR76,79968|XRCC3,XRCC3,7517|ZNF219,ZNF219,51222|ZNF446,ZNF446,55663|ZNF574,ZNF574,64763" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C6" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE=""/>
</MSIGDB>
