STANDARD_NAME	QI_PBMC_ZOSTAVAX_AGE_50_75YO_1DY_UP
SYSTEMATIC_NAME	M41123
COLLECTION	C7:VAX
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/QI_PBMC_ZOSTAVAX_AGE_50_75YO_1DY_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in peripheral blood mononuclear cell 1d vs 0d in seniors (50-75) after exposure to Zostavax , time point 1D. Comment: S2 Table has Illumina probe IDs
DESCRIPTION_FULL	Vaccination with attenuated live varicella zoster virus (VZV) can prevent zoster reactivation, but protection is incomplete especially in an older population. To decipher the molecular mechanisms underlying variable vaccine responses, T- and B-cell responses to VZV vaccination were examined in individuals of different ages including identical twin pairs. Contrary to the induction of VZV-specific antibodies, antigen-specific T cell responses were significantly influenced by inherited factors. Diminished generation of long-lived memory T cells in older individuals was mainly caused by increased T cell loss after the peak response while the expansion of antigen-specific T cells was not affected by age. Gene expression in activated CD4 T cells at the time of the peak response identified gene modules related to cell cycle regulation and DNA repair that correlated with the contraction phase of the T cell response and consequently the generation of long-lived memory cells. These data identify cell cycle regulatory mechanisms as targets to reduce T cell attrition in a vaccine response and to improve the generation of antigen-specific T cell memory, in particular in an older population.
PMID	27764254
GEOID	
AUTHORS	Qi Q,Cavanagh MM,Le Saux S,Wagar LE,Mackey S,Hu J,Maecker H,Swan GE,Davis MM,Dekker CL,Tian L,Weyand CM,Goronzy JJ
CONTRIBUTOR	HIPC SIGNATURES
CONTRIBUTOR_ORG	NIAID/HIPC SIGNATURES
EXACT_SOURCE	S2 Table
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072604/bin/ppat.1005892.s002.docx
SOURCE_MEMBERS	DUSP11,EXOSC10,FAF2,PPIAL4A,PSMG2,TCAF1,TOX3
GENE_SYMBOLS	DUSP11,EXOSC10,FAF2,PPIAL4A,PSMG2,TCAF1,TOX3
FOUNDER_NAMES