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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_MAPK1_UP" SYSTEMATIC_NAME="M1152" HISTORICAL_NAMES="" PMID="16909112" AUTHORS="Ramjaun AR,Tomlinson S,Eddaoudi A,Downward J" GEOID="" EXACT_SOURCE="Table 1: TGFb-upregulated genes (p38 dependent)" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="MOUSE_SEQ_ACCESSION" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Apoptotic genes dependent on MAPK1 [GeneID=5594] and up-regulated in AML12 cells (hepatocytes) after stimulation with TGFB1 [GeneID=7040]." DESCRIPTION_FULL="Transforming growth factor-beta (TGFbeta)-activated signalling pathways can lead to apoptosis, growth arrest or promotion of malignant behaviour, dependent on cellular context. The molecular mechanisms involved in TGFbeta-induced apoptosis remain controversial; although changes in gene expression are thought to be pivotal to the process, several different candidate apoptotic initiators and mediators have been proposed. Smad4, a critical component of the TGFbeta-induced transcriptional machinery, is shown here to be essential for induction of apoptosis. Gene expression analysis identified the proapoptotic Bcl-2 family members, Bmf and Bim, as induced by TGFbeta, dependent on both Smad4 and p38 function and the generation of reactive oxygen species. TGFbeta-induced Bmf and Bim localize to cellular membranes implicated in apoptosis. Inhibition of the TGFbeta-induced expression of both these proteins together provides significant protection of cells from apoptosis. The TGFbeta-triggered cell death programme thus involves induction of multiple BH3-only proteins during the induction of apoptosis." TAGS="" MEMBERS="AF032460,M12573,NM_019464,NM_021897,NM_130859,NM_138313" MEMBERS_SYMBOLIZED="BCL2L11,BMF,CARD10,HSPA1B,SH3GLB1,TP53INP1" MEMBERS_EZID="10018,29775,3304,51100,90427,94241" MEMBERS_MAPPING="AF032460,BCL2L11,10018|M12573,HSPA1B,3304|NM_019464,SH3GLB1,51100|NM_021897,TP53INP1,94241|NM_130859,CARD10,29775|NM_138313,BMF,90427" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
