STANDARD_NAME RB_DN.V1_DN SYSTEMATIC_NAME M2799 COLLECTION C6 MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/RB_DN.V1_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in primary keratinocytes from RB1 [Gene ID=5925] skin specific knockout mice. DESCRIPTION_FULL The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe with the loss of p107, demonstrating the functional compensation between pRb and p107. As p107 and p130 also exert overlapping functions in epidermis, we have generated Rb(F19/F19)K14cre;Rbl2-/- (pRb-;p130-) mice to analyze possible functional redundancies between pRb and p130. The epidermal phenotype was very similar between pRb- and pRb-;p130- mice, suggesting that pRb and p130 activities are not redundant in epidermis. Importantly, we can correlate the proliferation differences with specific changes in gene expression between pRb-, pRb-;p107- and pRb-;p130- primary keratinocytes using microarray analysis, and explain the phenotypes in the context of altered E2F expression and functionality. Our findings support a model in which the distinct retinoblastoma family members, in conjunction with E2F members, play a central role in regulating epidermal homeostasis through specific or overlapping activities. PMID 17932948 GEOID GSE9562 AUTHORS Lara MF,García-Escudero R,Ruiz S,Santos M,Moral M,Martínez-Cruz AB,Segrelles C,Lorz C,Paramio JM CONTRIBUTOR Pablo Tamayo CONTRIBUTOR_ORG Broad Institute EXACT_SOURCE RB -/- vs WT; bottom 150 genes (diff. of mean) FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1110007F12Rik,1110011C06Rik,1110055J05Rik,1200016E24Rik,2010002N04Rik,2610020O08Rik,2610528A11Rik,9230117N10Rik,AA407659,ADAM12,ADAMTS1,AGRIN,AI464131,ANKFY1,ANXA11,ANXA6,ARL1,ATF5,AW061234,BASP1,BC031181,BCCIP,BHLHB2,BNC1,BST2,C230093N12Rik,CALCB,CAP1,CAV1,CBR2,CCRN4L,CD44,CD9,CDC42SE2,CDIPT,CELSR1,CHAC1,CISH,COL18A1,CREB3L2,CST9,CTNNAL1,CTSC,CXCR7,D3UCLA1,D5ERTD593E,D6WSU176E,DDIT3,DDIT4,DDX3Y,DKK3,DNAJC4,DUSP14,DYNLL1,E030025L21Rik,EDG8,EFTUD1,EIF4E,F2RL1,FEZ2,FHL1,FLNA,FPR-RS4,FURIN,GADD45A,GJB2,GOSR2,H19,HIST1H2BC,HIST1H2BC /// HIST1H,Hist1h2bp,HIST2H3C1 /// HIST2H,HIST2H3C2,HS3ST1,HSPA5,IGFBP3,IRX4,KRT2-7,KRT2-8,KRT2-8 /// LOC434261,LAMA3 /// LOC669814,LAMB3,LAMC2,LGALS9,LMAN1,LOC434261 /// LOC675,LOC637870 /// LOC676,LRRC4,MAP2K1IP1,MELA,MICAL2,MMP13,MMP9,MOXD1,MRGPRA2 /// LOC66872,MVP,MYADM,MYL6 /// LOC433297 /,NDN /// PCTK1,NDRG1,NDRL,NEDD9,NFIL3,NSDHL,OASL2,P4HA1,PDCD6,PDGFB,PLXNA2,PMVK,PPBP,PPNR,PPP2R1B,PRKAR1A,PSCD1,PSMB10,PSME1,PSME2,RASL11B,RB1,RHOV,RPS2,S100A16,SC4MOL,SEC23A,SERPINA3A,SERPINA3G,SERPINB1A,SH3BP5L,SLC7A3,SLC7A5,SLCO2A1,SPRR2I,SQLE,ST8SIA2,STARD3NL,STC2,TLL1,TMCC3,TMEM42,TMEM50B,TMEM66,TNC,TTC15,TUBA1,UBE1DC1,UROS,USP18,V1RA6,WNT3 GENE_SYMBOLS TMEM140,ANKRD40,LCE1F,,SMIM3,NKAP,GPR15LG,IL33,UNC119B,ADAM12,ADAMTS1,AGRN,MYORG,ANKFY1,ANXA11,ANXA6,ARL1,ATF5,LIFR,BASP1,C18orf32,BCCIP,BHLHE40,BNC1,BST2,EEIG1,CALCB,CAP1,CAV1,,NOCT,CD44,CD9,CDC42SE2,CDIPT,CELSR1,CHAC1,CISH,COL18A1,CREB3L2,CST9,CTNNAL1,CTSC,ACKR3,,,,DDIT3,DDIT4,DDX3Y,DKK3,DNAJC4,DUSP14,DYNLL1,AGR3,S1PR5,EFL1,EIF4E,F2RL1,FEZ2,FHL1,FLNA,,FURIN,GADD45A,GJB2,GOSR2,H19,H2BC4,,,,HS3ST1,HSPA5,H2BC17,IGFBP3,IRX4,,,,,LAMB3,LAMC2,LGALS9,LMAN1,,,LRRC4,LAMTOR3,,MICAL2,MMP13,MMP9,MOXD1,,MVP,MYADM,,,NDRG1,,NEDD9,NFIL3,NSDHL,,P4HA1,PDCD6,PDGFB,PLXNA2,PMVK,PPBP,,PPP2R1B,PRKAR1A,CYTH1,PSMB10,PSME1,PSME2,RASL11B,RB1,RHOV,RPS2,S100A16,MSMO1,SEC23A,,,,SH3BP5L,SLC7A3,SLC7A5,SLCO2A1,,SQLE,ST8SIA2,STARD3NL,STC2,TLL1,TMCC3,TMEM42,TMEM50B,SARAF,TNC,TRAPPC12,TUBA4A,UBA5,UROS,USP18,,WNT3 FOUNDER_NAMES