STANDARD_NAME	RGAANNTTC_HSF1_01
SYSTEMATIC_NAME	M8746
COLLECTION	C3:TFT:TFT_LEGACY
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/RGAANNTTC_HSF1_01
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes having at least one occurrence of the highly conserved motif M68 RGAANNTTC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the HSF1 [GeneSymbol=HSF1] transcription factor binding site V$HSF1_01 (v7.4 TRANSFAC).
DESCRIPTION_FULL	Comprehensive identification of all functional elements encoded in the human genome is a fundamental need in biomedical research. Here, we present a comparative analysis of the human, mouse, rat and dog genomes to create a systematic catalogue of common regulatory motifs in promoters and 3' untranslated regions (3' UTRs). The promoter analysis yields 174 candidate motifs, including most previously known transcription-factor binding sites and 105 new motifs. The 3'-UTR analysis yields 106 motifs likely to be involved in post-transcriptional regulation. Nearly one-half are associated with microRNAs (miRNAs), leading to the discovery of many new miRNA genes and their likely target genes. Our results suggest that previous estimates of the number of human miRNA genes were low, and that miRNAs regulate at least 20% of human genes. The overall results provide a systematic view of gene regulation in the human, which will be refined as additional mammalian genomes become available.
PMID	15735639
GEOID	
AUTHORS	Xie X,Lu J,Kulbokas EJ,Golub TR,Mootha V,Lindblad-Toh K,Lander ES,Kellis M
CONTRIBUTOR	Xiaohui Xie
CONTRIBUTOR_ORG	Broad Institute
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	182-FIP,A2BP1,AAMP,ABCC5,ABCD1,ABHD3,ACTN2,ADAM15,ADAMTS2,ADAMTS9,ADCY6,ADCY8,ADM,AKAP13,ALS2CR8,AMICA,AMIGO2,AMOT,ANKRD22,ANKRD28,ANKS1,AOC2,APG4A,ARHGAP21,ARHGAP6,ARL6IP2,ARMCX3,ASNS,ATP1B2,ATP1B3,ATP2C1,ATP6V1A,B4GALT5,B7-H4,BACH,BAZ1A,BCAP31,BCL6,BCL9,BDNF,BMP3,BMPR2,BNC2,BTBD5,C10orf53,C14orf155,C14orf32,C14orf4,C15orf5,C1orf32,C20orf114,C20orf179,C21orf24,C21orf63,C21orf94,C7,C7orf23,C9orf60,CACNA1A,CACNA1D,CACNA2D2,CAMKK2,CASQ2,CBFA2T3,CBX3,CCM1,CCM2,CCT2,CCT3,CCT4,CCT8,CD9,CDH10,CEPT1,CHD1,CHD2,CHML,CHORDC1,CHST2,CHST8,CISH,CKLFSF4,CLDN2,CLECSF8,CNTF,CNTFR,COL13A1,COL4A5,COL4A6,COL6A3,CPA2,CRA,CREBBP,CREM,CRISP1,CRYAB,CTAGE4,CUL2,CUTL1,CXCR4,CYLD,CYorf15B,CYP1A1,CYP46A1,DAPK1,DAPP1,DAZ2,DAZL,DBCCR1L,DBI,DD5,DDX17,DER1,DKFZp761C169,DMD,DMN,DMRT1,DMRTA1,DMRTB1,DMTF1,DNAJA1,DNAJB1,DNAJB5,DNCI2,DND1,DUSP1,E2F3,ECEL1,EDN2,EFA6R,EFNB3,EGF,EGR3,EHD1,EIF4A2,EIF4ENIF1,EIF4G2,ELAVL4,ELF2,ELK3,ELOVL5,ELYS,ENPP2,EOMES,EPHA2,ERO1LB,F25965,FAM31B,FANCC,FAP,FBLN5,FGF9,FHL1,FKBP4,FLJ10997,FLJ11021,FLJ12770,FLJ14007,FLJ20174,FLJ22662,FLJ23191,FLJ23657,FLJ32447,FLJ33069,FLJ35409,FLJ35757,FLJ35821,FLJ35834,FLJ42280,FLJ42957,FLJ45455,FLJ45721,FLNC,FLT4,FOXP2,FOXR1,FRBZ1,FSIP2,FSTL3,FXYD2,G0S2,GAD1,GAD2,GASP2,GATA3,GCH1,GIPC2,GLRA3,GNAS,GPR119,GPR17,GREB1,GRIK1,GRM1,GRM8,GSN,GSTA5,H2AFZ,HBXAP,HCFC1,HCN4,HDAC4,HES1,HIC,HIP1R,HIPK1,HIS1,HIVEP2,HLA-B,HNRPA2B1,HOXB1,HOXB5,HOXB8,HOXD13,HS6ST3,HSPA1A,HSPA1B,HSPA1L,HSPA8,HSPB1,HSPB2,HSPB8,HSPC138,HSPD1,HSPE1,HSPH1,HYPB,HYPK,IBRDC2,ID4,IGFBP5,IL1F5,IL6ST,IL9,IRF1,ISYNA1,ITGA8,JAM3,JUN,KCNQ1,KCNS2,KIAA0423,KIAA0460,KIAA0663,KIAA0779,KIAA0922,KIAA1036,KIAA1285,KIAA1318,KIAA1409,KIAA1573,KIAA1632,KIAA2024,KNTC1,KPI2,KRTHB5,LAP3,LENEP,LHFPL2,LHX3,LMAN2L,LOC112869,LOC113251,LOC163782,LOC286016,LOC388152,LOC389792,LOC56965,LOC63929,LOC90410,LOC90693,LRP1,LUZP1,MAGEH1,MAGI-3,MAK3,MAP2,MAP2K1IP1,MAP3K7IP2,MAP4K4,MAP6,MAPK14,MARK3,MAT2A,MBNL2,ME1,MEF2C,MESDC1,MGC10744,MGC10765,MGC15677,MGC26597,MGC27121,MGC33309,MGC33864,MGC34646,MGC34725,MGC34799,MGC4171,MGLL,MMP16,MOBP,MORF4L2,MR-1,MRPL45,MRPS6,MYOCD,NAG8,NEK6,NETO2,NFAM1,NFATC3,NFATC4,NNAT,NOB1P,NOL4,NOSIP,NR4A2,NR4A3,NRF1,NRXN3,NT5C3,NTF5,NYD-SP28,OGT,OSR2,OTP,OTX2,P4HA1,PACSIN3,PAK1IP1,PAK3,PARVB,PAX3,PCDH10,PDE6D,PEN2,PERQ1,PHF6,PIP5K1A,PIP5K1C,PIP5K3,PKN3,PLEC1,PLEKHB1,PLOD,PLXDC2,PLXNA2,PLXNC1,PNMA1,PNRC1,POLD4,POPDC3,PPID,PPM1D,PPP2R2C,PPP2R5C,PPT2,PRDM1,PRDM12,PSEN1,PSMD10,PTD015,PTDSR,PTGIS,PTHLH,PTPRA,PURA,RAB6B,RALGDS,RASGEF1A,RASGRP2,RAVER1,RBPMS,RBPSUH,RFX3,RG9MTD2,RGS1,RGS8,RHBDL6,RIMS2,RORB,RORC,RPH3AL,RPIP8,RTN1,SARG,SAS,SCAMP1,SCG2,SCUBE3,SELB,SEMA3A,SERPINH1,SFRS1,SFRS16,SHANK1,SHARP,SHC3,SHFM3,SHRML,SIAT8A,SIX4,SLC24A4,SLC2A4,SLC35F3,SLC36A2,SMAD1,SMYD1,SOCS2,SP4,SPAG9,SPIN,SPO11,SRP54,SSBP3,SSTK-IP,ST13,STAG2,STARD13,STC1,STIP1,STK22C,STX12,SYNJ1,TA-LRRP,TA-NFKBH,TAIP-2,TFAP2BL1,TLK1,TM4SF13,TM4SF6,TNFAIP1,TNFSF6,TNPO3,TP73L,TPM2,TRDN,TRERF1,TREX1,TRIP10,TRPC6,TRPS1,TYR,TZFP,U2AF1L3,UMODL1,UNQ2446,USP34,WDR12,WNT10B,WWP1,XPO1,YWHAG,ZBTB2,ZFX,ZNF161,ZNF212,ZNF288,ZNF410,ZP3
GENE_SYMBOLS	NUFIP2,RBFOX1,AAMP,ABCC5,ABCD1,ABHD3,ACTN2,ADAM15,ADAMTS2,ADAMTS9,ADCY6,ADCY8,ADM,AKAP13,CARF,JAML,AMIGO2,AMOT,ANKRD22,ANKRD28,ANKS1A,AOC2,ATG4A,ARHGAP21,ARHGAP6,ATL2,ARMCX3,ASNS,ATP1B2,ATP1B3,ATP2C1,ATP6V1A,B4GALT5,VTCN1,ACOT7,BAZ1A,BCAP31,BCL6,BCL9,BDNF,BMP3,BMPR2,BNC2,KLHL28,C10orf53,FSCB,MAPK1IP1L,IRF2BPL,,ILDR2,BPIFB1,BANF2,LINC00114,EVA1C,LINC00314,C7,TMEM243,ZER1,CACNA1A,CACNA1D,CACNA2D2,CAMKK2,CASQ2,CBFA2T3,CBX3,KRIT1,CCM2,CCT2,CCT3,CCT4,CCT8,CD9,CDH10,CEPT1,CHD1,CHD2,CHML,CHORDC1,CHST2,CHST8,CISH,CMTM4,CLDN2,CLEC4D,CNTF,CNTFR,COL13A1,COL4A5,COL4A6,COL6A3,CPA2,MTMR11,CREBBP,CREM,CRISP1,CRYAB,CTAGE4,CUL2,CUX1,CXCR4,CYLD,CYP1A1,CYP46A1,TXLNGY,DAPK1,DAPP1,DAZ2,DAZL,BRINP3,DBI,UBR5,DDX17,DERL1,GPBP1,DMD,SYNM,DMRT1,DMRTA1,DMRTB1,DMTF1,DNAJA1,DNAJB1,DNAJB5,DYNC1I2,DND1,DUSP1,E2F3,ECEL1,EDN2,PSD3,EFNB3,EGF,EGR3,EHD1,EIF4A2,EIF4ENIF1,EIF4G2,ELAVL4,ELF2,ELK3,ELOVL5,AHCTF1,ENPP2,EOMES,EPHA2,ERO1B,LIN37,DENND1B,FANCC,FAP,FBLN5,FGF9,FHL1,FKBP4,ZNF654,RSRC2,TOMM40L,ZFAND1,SIDT1,PLBD1,NDNF,ODAPH,CCDC140,TMEM71,MIR137HG,MARCHF10,C12orf50,IQUB,SEM1,LINC00173,SHISA6,,FLNC,FLT4,FOXP2,FOXR1,ZBTB41,FSIP2,FSTL3,FXYD2,G0S2,GAD1,GAD2,GPRASP2,GATA3,GCH1,GIPC2,GLRA3,GNAS,GPR119,GPR17,GREB1,GRIK1,GRM1,GRM8,GSN,GSTA5,H2AZ1,RSF1,HCFC1,HCN4,HDAC4,HES1,MDFIC,HIP1R,HIPK1,HTN1,HIVEP2,HLA-B,HNRNPA2B1,HOXB1,HOXB5,HOXB8,HOXD13,HS6ST3,HSPA1A,HSPA1B,HSPA1L,HSPA8,HSPB1,HSPB2,HSPB8,HIKESHI,HSPD1,HSPE1,HSPH1,SETD2,HYPK,RNF144B,ID4,IGFBP5,IL36RN,IL6ST,IL9,IRF1,ISYNA1,ITGA8,JAM3,JUN,KCNQ1,KCNS2,TOGARAM1,RPRD2,ZC3H11A,TMCC1,TMEM131L,VASH1,ZNF777,RTL9,UNC79,CACHD1,EPG5,UBR3,KNTC1,LMTK2,KRT85,LAP3,LENEP,LHFPL2,LHX3,LMAN2L,SGF29,LARP4,KANK4,TPI1P2,GOLGA2P7,IER5L,PARP6,XPNPEP3,IFT20,CCDC126,LRP1,LUZP1,MAGEH1,MAGI3,NAA50,MAP2,LAMTOR3,TAB2,MAP4K4,MAP6,MAPK14,MARK3,MAT2A,MBNL2,ME1,MEF2C,TLNRD1,TMEM107,DCAF10,ALKBH6,PIP5K1P1,FNDC9,GOT1L1,ARL6IP6,CLVS1,SLC25A41,IZUMO1,GDPD3,MGLL,MMP16,MOBP,MORF4L2,PNKD,MRPL45,MRPS6,MYOCD,SND1-IT1,NEK6,NETO2,NFAM1,NFATC3,NFATC4,NNAT,NOB1,NOL4,NOSIP,NR4A2,NR4A3,NRF1,NRXN3,NT5C3A,NTF4,CCDC65,OGT,OSR2,OTP,OTX2,P4HA1,PACSIN3,PAK1IP1,PAK3,PARVB,PAX3,PCDH10,PDE6D,PSENEN,GIGYF1,PHF6,PIP5K1A,PIP5K1C,PIKFYVE,PKN3,PLEC,PLEKHB1,PLOD1,PLXDC2,PLXNA2,PLXNC1,PNMA1,PNRC1,POLD4,POPDC3,PPID,PPM1D,PPP2R2C,PPP2R5C,PPT2,PRDM1,PRDM12,PSEN1,PSMD10,AAMDC,JMJD6,PTGIS,PTHLH,PTPRA,PURA,RAB6B,RALGDS,RASGEF1A,RASGRP2,RAVER1,RBPMS,RBPJ,RFX3,TRMT10A,RGS1,RGS8,RHBDF2,RIMS2,RORB,RORC,RPH3AL,RUNDC3A,RTN1,C1orf116,TSPAN31,SCAMP1,SCG2,SCUBE3,EEFSEC,SEMA3A,SERPINH1,SRSF1,CLASRP,SHANK1,SPEN,SHC3,FBXW4,,ST8SIA1,SIX4,SLC24A4,SLC2A4,SLC35F3,SLC36A2,SMAD1,SMYD1,SOCS2,SP4,SPAG9,SPIN1,SPO11,SRP54,SSBP3,TSACC,ST13,STAG2,STARD13,STC1,STIP1,TSSK3,STX12,SYNJ1,LRRC8B,NFKBID,CSRNP3,TFAP2D,TLK1,TSPAN13,TSPAN6,TNFAIP1,FASLG,TNPO3,TP63,TPM2,TRDN,TRERF1,TREX1,TRIP10,TRPC6,TRPS1,TYR,ZBTB32,U2AF1L4,UMODL1,NRN1L,USP34,WDR12,WNT10B,WWP1,XPO1,YWHAG,ZBTB2,ZFX,VEZF1,ZNF212,ZBTB20,ZNF410,ZP3
FOUNDER_NAMES