STANDARD_NAME	RODRIGUES_THYROID_CARCINOMA_UP
SYSTEMATIC_NAME	M3910
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/RODRIGUES_THYROID_CARCINOMA_UP
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Genes up-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to anaplastic thyroid carcinoma (ATC).
DESCRIPTION_FULL	Information on gene alterations associated to poorly differentiated (PDTC) and anaplastic thyroid carcinomas (ATC) is scarce. Using human cancer cell lines as a tool for gene discovery, we performed a cytogenetic and oligo-array analysis in five new cell lines derived from two PDTC and three ATC. In PDTC we evidenced, as important, the involvement of the MAPK/ERK kinase pathway, and downregulation of a group of suppressor genes that include E-cadherin. In ATC, downregulation of a specific group of oncosuppressor genes was also observed. Our ATC cell lines presented chromosomal markers of gene amplification, and we were able to identify for the first time the nature of the involved amplicon target genes. We found that the main molecular differences between the two cell line types were related to signal transduction pathways, cell adhesion and motility process. TaqMan experiments performed for five amplicon target genes and for two genes, which allowed a clear distinction between ATC and PDTC: CDH13 and PLAU corroborated array results, not only in the cell lines, but also in an additional set of primary 14 PDTC and three ATC. We suggest that our findings may represent new tools for the development of more effective therapies to the hitherto untreatable ATC.
PMID	17406368
GEOID	
AUTHORS	Rodrigues RF,Roque L,Krug T,Leite V
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 5S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	203335_at,209576_at,209759_s_at,214260_at,218681_s_at,219117_s_at,223595_at,225334_at,225626_at,225861_at,225972_at,226448_at,227692_at,227722_at,228867_at,230748_at,235466_s_at
GENE_SYMBOLS	PHYH,GNAI1,ECI1,COPS8,SDF2L1,FKBP11,ARHGAP42,BORCS7,PAG1,MCRIP2,TMEM64,FAM89A,GNAI1,RPS23,TATDN3,SLC16A6,DISP1
FOUNDER_NAMES