STANDARD_NAME RODWELL_AGING_KIDNEY_UP SYSTEMATIC_NAME M5389 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/RODWELL_AGING_KIDNEY_UP NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes whose expression increases with age in normal kidney. DESCRIPTION_FULL In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age. PMID 15562319 GEOID GSE362 AUTHORS Rodwell GE,Sonu R,Zahn JM,Lund J,Wilhelmy J,Wang L,Xiao W,Mindrinos M,Crane E,Segal E,Myers BD,Brooks JD,Davis RW,Higgins J,Owen AB,Kim SK CONTRIBUTOR John Newman CONTRIBUTOR_ORG University of Washington EXACT_SOURCE Table 3S: coefficient > 0 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1405_i_at,200002_at,200003_s_at,200019_s_at,200022_at,200025_s_at,200076_s_at,200088_x_at,200091_s_at,200095_x_at,200618_at,200634_at,200654_at,200678_x_at,200715_x_at,200725_x_at,200736_s_at,200757_s_at,200795_at,200904_at,200905_x_at,200909_s_at,200916_at,200951_s_at,200953_s_at,200986_at,201004_at,201011_at,201079_at,201126_s_at,201141_at,201189_s_at,201288_at,201331_s_at,201426_s_at,201506_at,201587_s_at,201590_x_at,201601_x_at,201645_at,201666_at,201700_at,201720_s_at,201721_s_at,201743_at,201744_s_at,201762_s_at,201792_at,201797_s_at,201798_s_at,201818_at,201852_x_at,201859_at,201871_s_at,201954_at,202018_s_at,202117_at,202145_at,202156_s_at,202180_s_at,202185_at,202208_s_at,202237_at,202238_s_at,202307_s_at,202310_s_at,202336_s_at,202357_s_at,202403_s_at,202404_s_at,202510_s_at,202626_s_at,202649_x_at,202659_at,202686_s_at,202766_s_at,202800_at,202803_s_at,202804_at,202837_at,202910_s_at,202953_at,202957_at,202988_s_at,202992_at,203005_at,203066_at,203104_at,203219_s_at,203379_at,203416_at,203423_at,203476_at,203477_at,203485_at,203570_at,203729_at,203769_s_at,203798_s_at,203828_s_at,203868_s_at,203878_s_at,203879_at,203882_at,203892_at,203939_at,203940_s_at,203954_x_at,204057_at,204070_at,204073_s_at,204122_at,204123_at,204150_at,204154_at,204191_at,204198_s_at,204215_at,204220_at,204232_at,204259_at,204279_at,204304_s_at,204319_s_at,204328_at,204336_s_at,204438_at,204446_s_at,204470_at,204494_s_at,204537_s_at,204558_at,204589_at,204655_at,204670_x_at,204701_s_at,204774_at,204781_s_at,204806_x_at,204820_s_at,204858_s_at,204882_at,204912_at,204932_at,204933_s_at,204961_s_at,205044_at,205047_s_at,205081_at,205098_at,205174_s_at,205180_s_at,205269_at,205477_s_at,205488_at,205547_s_at,205582_s_at,205668_at,205681_at,205692_s_at,205713_s_at,205784_x_at,205789_at,205857_at,205875_s_at,205890_s_at,205898_at,206039_at,206370_at,206595_at,206666_at,206682_at,206687_s_at,206767_at,206860_s_at,206980_s_at,207134_x_at,207173_x_at,207180_s_at,207191_s_at,207339_s_at,207413_s_at,207571_x_at,207610_s_at,207740_s_at,207752_x_at,207813_s_at,207827_x_at,207927_at,208091_s_at,208130_s_at,208205_at,208306_x_at,208451_s_at,208554_at,208636_at,208637_x_at,208658_at,208659_at,208700_s_at,208729_x_at,208747_s_at,208812_x_at,208829_at,208837_at,208894_at,209040_s_at,209083_at,209114_at,209118_s_at,209138_x_at,209140_x_at,209165_at,209166_s_at,209196_at,209250_at,209312_x_at,209341_s_at,209373_at,209374_s_at,209448_at,209506_s_at,209539_at,209574_s_at,209708_at,209795_at,209823_x_at,209869_at,209879_at,209946_at,209960_at,210427_x_at,210495_x_at,210514_x_at,210538_s_at,210605_s_at,210629_x_at,210704_at,210776_x_at,210785_s_at,210915_x_at,210933_s_at,210982_s_at,210986_s_at,210987_x_at,210988_s_at,211121_s_at,211241_at,211284_s_at,211340_s_at,211366_x_at,211367_s_at,211368_s_at,211430_s_at,211528_x_at,211529_x_at,211530_x_at,211546_x_at,211582_x_at,211587_x_at,211650_x_at,211654_x_at,211656_x_at,211719_x_at,211795_s_at,211796_s_at,211799_x_at,211911_x_at,211990_at,211991_s_at,212013_at,212067_s_at,212070_at,212190_at,212288_at,212314_at,212419_at,212464_s_at,212489_at,212566_at,212587_s_at,212588_at,212592_at,212646_at,212663_at,212671_s_at,212680_x_at,212790_x_at,212791_at,212796_s_at,212827_at,212873_at,212874_at,212969_x_at,212998_x_at,213060_s_at,213160_at,213247_at,213258_at,213293_s_at,213363_at,213414_s_at,213503_x_at,213531_s_at,213566_at,213603_s_at,213728_at,213733_at,213811_x_at,213832_at,213857_s_at,213915_at,213932_x_at,213975_s_at,213993_at,213994_s_at,214022_s_at,214084_x_at,214181_x_at,214247_s_at,214321_at,214400_at,214428_x_at,214459_x_at,214574_x_at,214669_x_at,214677_x_at,214719_at,214768_x_at,214770_at,214803_at,214836_x_at,214916_x_at,215020_at,215076_s_at,215121_x_at,215176_x_at,215193_x_at,215313_x_at,215379_x_at,215633_x_at,215719_x_at,215829_at,215946_x_at,216041_x_at,216194_s_at,216383_at,216442_x_at,216526_x_at,216557_x_at,216589_at,216598_s_at,216834_at,216913_s_at,217022_s_at,217028_at,217118_s_at,217181_at,217239_x_at,217360_x_at,217362_x_at,217378_x_at,217436_x_at,217456_x_at,217478_s_at,217497_at,217513_at,217733_s_at,217757_at,217763_s_at,217795_s_at,218002_s_at,218007_s_at,218081_at,218130_at,218223_s_at,218232_at,218358_at,218387_s_at,218530_at,218543_s_at,218567_x_at,218627_at,218638_s_at,218777_at,218872_at,218943_s_at,218960_at,219040_at,219332_at,219359_at,219386_s_at,219423_x_at,219431_at,219471_at,219574_at,219593_at,219620_x_at,219768_at,219947_at,220273_at,220371_s_at,220704_at,221004_s_at,221253_s_at,221530_s_at,221565_s_at,221651_x_at,221671_x_at,221698_s_at,221731_x_at,221739_at,221755_at,221798_x_at,221799_at,221827_at,221840_at,221872_at,221875_x_at,221900_at,221933_at,222288_at,222409_at,222512_at,222549_at,222688_at,222976_s_at,222986_s_at,223044_at,223164_at,223204_at,223218_s_at,223280_x_at,223322_at,223343_at,223361_at,223431_at,223454_at,223484_at,223553_s_at,223640_at,223773_s_at,224252_s_at,224356_x_at,224358_s_at,224531_at,224694_at,224701_at,224710_at,224724_at,224733_at,224791_at,224795_x_at,224874_at,224885_s_at,224910_at,224915_x_at,224916_at,224925_at,224927_at,224928_at,224929_at,224964_s_at,225045_at,225185_at,225190_x_at,225293_at,225353_s_at,225373_at,225415_at,225520_at,225524_at,225602_at,225681_at,225701_at,225710_at,225725_at,225798_at,225868_at,225929_s_at,225931_s_at,226009_at,226017_at,226035_at,226074_at,226147_s_at,226219_at,226474_at,226496_at,226603_at,226605_at,226621_at,226633_at,226723_at,226725_at,226731_at,226743_at,226748_at,226769_at,226771_at,226818_at,226841_at,226875_at,226905_at,227006_at,227095_at,227125_at,227140_at,227266_s_at,227295_at,227307_at,227400_at,227550_at,227628_at,227697_at,227726_at,227752_at,228055_at,228094_at,228315_at,228333_at,228367_at,228376_at,228521_s_at,228531_at,228750_at,228754_at,228937_at,229041_s_at,229101_at,229256_at,229295_at,229390_at,229625_at,229640_x_at,229659_s_at,229860_x_at,229973_at,230000_at,230036_at,230061_at,230276_at,230326_s_at,230381_at,230383_x_at,230466_s_at,230532_at,230550_at,230708_at,230836_at,230865_at,230925_at,230966_at,230986_at,231579_s_at,231779_at,231887_s_at,231956_at,232024_at,232231_at,232510_s_at,232914_s_at,233510_s_at,233959_at,234985_at,234987_at,235085_at,235199_at,235385_at,235421_at,235527_at,235529_x_at,235571_at,235964_x_at,236539_at,238034_at,238327_at,238604_at,238809_at,238935_at,239082_at,239332_at,239519_at,240830_at,241302_at,241347_at,242521_at,242957_at,243271_at,243374_x_at,244061_at,244498_x_at,244567_at,244602_at,244876_at,31837_at,32402_s_at,40420_at,44790_s_at,57082_at,60471_at,65521_at,78495_at GENE_SYMBOLS CCL5,RPL35,RPL28,FAU,RPL18,RPL27,KXD1,RPL12,RPS25,RPS10,LASP1,PFN1,P4HB,GRN,RPL13A,RPL10,RHOA,CALU,SPARCL1,HLA-E,HLA-E,RPLP2,TAGLN2,CCND2,CCND2,SERPING1,SSR4,RPN1,SYNGR2,MGAT1,GPNMB,ITPR3,ARHGDIB,STAT6,VIM,TGFBI,IRAK1,ANXA2,IFITM1,TNC,TIMP1,CCND3,LAPTM5,LAPTM5,CD14,LUM,PSME2,AEBP1,VARS1,MYOF,LPCAT1,COL3A1,SRGN,UBXN1,ARPC1B,LTF,ARHGAP1,LY6E,CELF2,MVP,PLOD3,ARL4C,NNMT,NNMT,TAP1,COL1A1,PAM,CFB,COL1A2,COL1A2,TNFAIP2,LYN,RPS19,PSMB10,AXL,FBN1,SLC1A3,ITGB2,ABCC1,TRAFD1,ADGRE5,C1QB,HCLS1,RGS1,C7,LTBR,CHST15,CSF1R,APRT,RPS6KA1,CD53,RBP1,TPBG,COL15A1,RTN1,LOXL1,EMP3,STS,VSNL1,IL32,VCAM1,MMP11,PIK3CD,IRF9,WFDC2,NT5E,VASH1,CLDN3,IRF8,PLAAT4,MYRF,TYROBP,LIG3,STAB1,CDO1,IFNAR1,RUNX3,TMEM243,GMFG,FCER1G,MMP7,PSMB9,PROM1,RGS10,TMC6,RGS19,MRC1,ALOX5,CXCL1,C15orf39,GABRE,RAD54L,NUAK1,CCL5,HLA-DRB1,STOML1,EVI2A,FAS,HLA-F,BTN3A3,TYMP,ARHGAP25,IL10RA,TNFRSF11B,TNFRSF11B,NCF1,GABRP,ASNS,CRIP1,CCR1,QPCT,ADAM8,LCP2,AMBP,GZMA,TAGLN,GGT5,LY75,BCL2A1,CD38,COMP,ARVCF,CD1D,SLC18A2,TREX1,GABBR1,CX3CR1,RAB33A,PIK3CG,CST6,GZMK,CLEC10A,PTPN6,RBMS3,MIOS,FLT3LG,TPSAB1,CDH11,HTATIP2,ISLR,LTB,SCN5A,THEMIS2,ADGRE2,NUP62,PRB1,FDXR,SNCA,HTR7,VOPP1,TBXAS1,PCDHA9,HLA-DRB1,C4A,POU4F3,ACTN1,ACTN1,PDIA4,CLIC1,TKT,HLA-B,C1S,HLA-B,TAPBP,TMED3,HLA-DRA,PSMB8,CORO1A,TSPAN1,TUBA1A,IGLC2,HLA-B,AATF,MAN2B1,WDR46,DEGS1,HLA-DRB1,IKBKB,MALL,IGHM,HTATIP2,NR2F1,ARHGEF6,LDLRAD4,MOXD1,CD69,HLA-DQB1,ADRA2A,SELPLG,VEGFC,HGF,ANXA2,FN1,HLA-G,BIRC3,MFGE8,LST1,FEZ2,TCF3,THEMIS2,TRBC1,FSCN1,HLA-DRA,TPM1,TPM1,PRUNE1,DOK1,ANXA2P3,GRN,MCAM,CASP1,CASP1,CASP1,IGHG1,HLA-G,HLA-G,HLA-G,SNCA,LST1,CHRNA3,IGHV3-23,HLA-DQB1,HLA-DQB1,FN1,FYB1,TRBC2,,HLA-B,HLA-DPA1,HLA-DPA1,PXDN,C1R,ADGRG1,SERPINE2,FNBP1,SEL1L3,ZCCHC24,FN1,COL5A1,MAP4,PTPRC,PTPRC,JCHAIN,RFTN1,FKBP15,HLA-DQA1,PPP1R14B,RPL13A,C1orf216,TBC1D2B,IGHM,ARHGAP45,,EML3,HLA-DQB1,CHI3L2,DOCK2,SVEP1,TFPI,TRIM22,CA5BP1,RPS19,ANXA2,RAB3GAP1,RNASE6,RAC2,LAMP1,MYO1F,TCF3,KCND3,CD47,NKG7,HLA-A,LYZ,SPON1,SPON1,IFITM1,NCF1,LST1,DKK3,CCN3,INSL3,C4A,HLA-B,LST1,,IGLC2,SLC46A3,IGKV2D-28,MSR1,CDH6,,,NRXN3,COL3A1,IGLC2,IGKV1D-39,HLA-DRB1,HLA-A,IGLC2,LST1,FAS,SHANK2,IGLL3P,GRN,TBCB,RPL18AP16,FN1,HLA-B,IGHV3-21,SNORA70,CCL2,RGS1,RRP12,IGHA1,CXCR4,KIAA0930,,IGHV3-47,,HLA-DRB6,IGKV1OR2-108,HLA-J,HLA-E,HLA-DMA,TYMP,MILR1,TMSB10,A2M,RAB31,TMEM43,CXCL14,RPS27L,ADISSP,CYBC1,PLEKHO1,C1QA,CRELD2,PGLS,FHOD1,PARP12,DPP3,DRAM1,SPON2,REEP4,TESC,RIGI,TMPRSS4,CORO7,MICALL2,PGGHG,SLAMF8,TNFRSF25,ARHGAP10,RUBCNL,MARCHF1,SLC15A3,TOR4A,VTCN1,CLEC4A,IL17B,SLC12A9,IKZF1,ITM2C,TXNDC5,BHLHE41,CALHM2,IGKC,IGKC,CLEC7A,VCAN,MYDGF,EHBP1L1,RPS2,CHPF2,RBCK1,PTPRE,RARRES1,HLA-F,COL8A2,NLGN4X,,CORO1C,NUB1,CLDN1,ACER3,TPM3,SHISA5,SLC40A1,CCM2,GASK1B,NFKBIZ,MS4A6A,RASSF5,MS4A7,ABRACL,BLOC1S4,CXCL16,C15orf48,DOK3,HCST,SNHG12,FXYD5,MS4A6A,MS4A7,GPR61,ANTXR1,PARP14,RAB34,SULF2,CMTM3,ASAP1,IGKC,POLR1D,KRTCAP2,CARHSP1,ZFAS1,STING1,PREX1,PPP1R18,SETD7,STING1,GNG2,CCDC88A,MRAS,RPL35A,COL27A1,C1QC,VSIR,DTX3L,MTHFD1L,ANTXR2,GLIPR2,CTHRC1,AKNA,GNB4,ZMAT3,JAZF1,TRIM47,RNF213,RNF213,DPCD,CMTM7,USP31,PPM1M,PIGR,ARHGAP30,NLRC5,ZCCHC7,SAMD9L,DGKQ,OSMR,RAB8B,SVBP,SLFN5,ITGA1,SLFN11,LYSMD2,FIBIN,ATP8B2,MPEG1,MPEG1,DOCK11,RFLNB,PPP1R14A,LEPROT,IFNAR2,INHBA,FYB1,IKBIP,TSPAN18,NFIX,GFRA1,GPX8,SOCS3,RNF166,SPTLC3,NAPSB,JAML,ZMAT3,ZEB2,ALPK2,GGTA1,RAB4B,SAMD9,COL14A1,SLC6A6,LACC1,ITGB2-AS1,IL17RA,PGM2L1,IL17RA,CALHM6,GBP5,NUS1,,C4orf48,ERICH3,RNF213,SAMD9L,TM4SF18,CYRIA,HIKESHI,RHEX,SLFN5,,CXorf38,MS4A6A,PRICKLE1,ST8SIA4,LIX1,APBB1IP,IL4I1,KLF8,TIMP2,IRAK2,PALD1,RNF213,GIMAP2,RUNX2,DPP3,SYTL2,PARVG,ADCY10P1,LDLRAD3,SAMHD1,PRAG1,RNF125,MARCHF1,,DLGAP1,SAMHD1,MIR34AHG,SAMHD1,PTPN22,CANX,ODF3B,,,RPS27L,FZD3,LINC02086,,SCARNA17,C7,RNF213,CARD8-AS1,VWCE,,,,UBE2Q2P16,HAVCR1,,,LMF2,SYMPK,STK10,RUBCNL,LDLRAP1,RIN3,UBE2D4,ZNF783 FOUNDER_NAMES