STANDARD_NAME	RUNNE_GENDER_EFFECT_UP
SYSTEMATIC_NAME	M17072
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/RUNNE_GENDER_EFFECT_UP
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Up-regulated genes detecting gender effects in global expression profiling studies.
DESCRIPTION_FULL	Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease-modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in development. In this report, we describe a large battery of transcriptomic tests explored as state biomarker candidates. In an attempt to exploit the known neuroinflammatory and transcriptional perturbations of disease, we measured relevant mRNAs in peripheral blood cells. The performance of these potential markers was weak overall, with only one mRNA, immediate early response 3 (IER3), showing a modest but significant increase of 32% in HD samples compared with controls. No statistically significant differences were found for any other mRNAs tested, including a panel of 12 RNA biomarkers identified in a previous report [Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV, et al. (2005) Proc Natl Acad Sci USA 102:11023-11028]. The present results may nonetheless inform the future design and testing of HD biomarker strategies.
PMID	17724341
GEOID	GSE8762
AUTHORS	Runne H,Kuhn A,Wild EJ,Pratyaksha W,Kristiansen M,Isaacs JD,Régulier E,Delorenzi M,Tabrizi SJ,Luthi-Carter R
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2, 5S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1560800_at,1570360_s_at,201909_at,204409_s_at,204410_at,205000_at,205001_s_at,206279_at,206624_at,206700_s_at,208067_x_at,210322_x_at,211149_at,214131_at,223645_s_at,223646_s_at,228492_at,230760_at,232618_at,236694_at,244482_at
GENE_SYMBOLS	,DDX3Y,RPS4Y1,EIF1AY,EIF1AY,DDX3Y,DDX3Y,PRKY,USP9Y,KDM5D,UTY,UTY,UTY,TXLNGY,TXLNGY,TXLNGY,USP9Y,ZFY,TXLNGY,TXLNGY,
FOUNDER_NAMES