STANDARD_NAME	SANA_TNF_SIGNALING_UP
SYSTEMATIC_NAME	M17466
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/SANA_TNF_SIGNALING_UP
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Genes up-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124].
DESCRIPTION_FULL	To investigate the potential molecular mediators of tissue-specific recruitment, we explored the influence of different cytokine challenges on gene expression regulation in five primary endothelial cells (ECs), representing two different phenotypes: iliac artery and aortic (macrovascular); lung, colon and dermal (microvascular). We challenged ECs with cytokines that elicit different patterns of inflammatory and immune responses in immune cells: tumor necrosis factor (TNF-alpha), interferon-gamma (IFN-gamma) or interleukin-4 (IL-4), and used microarrays containing approximately 40,000 unique cDNAs, to assess changes in differential gene expression relative to untreated cells. Five hundred and sixty three sequences changed by at least 2.5 fold in one or more of the 15 possible EC /cytokine combinations. The list included highly regulated adhesion molecules, chemokines, cytokines, metalloproteases, and IFN-gamma-induced genes. Overall, IFN-gamma caused the largest number of gene expression changes and its profile was least correlated with IL-4. In addition to clusters that were predominantly EC/cytokine specific, we also observed several clusters that were regulated by more than one cytokine across several ECs. Furthermore, we identified genes that were reciprocally expressed in response to different cytokines that could serve as markers of inflammatory and immune expression. These results confirm the importance of microenvironment in primary ECs that could have important applications in developing targeted therapies for vascular diseases.
PMID	15749026
GEOID	GSE569
AUTHORS	Sana TR,Janatpour MJ,Sathe M,McEvoy LM,McClanahan TK
CONTRIBUTOR	Yujin Hoshida
CONTRIBUTOR_ORG	Broad Institute
EXACT_SOURCE	GSE569: top 100 from COLON_TNFA DERMAL_TNFA ILIAC_TNFA AORTIC_TNFA LUNG_TNFA
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AAC35357,AAC59868,AAK29401,AB000115,AB005894,AB013847,AB014553,AB020598,AB020863,AB032973,AB037784,AB044545,AF008591,AF019225,AF027706,AF035269,AF051152,AF070674,AF095844,AF118767,AF123050,AF126780,AF329840,AF385628,AJ277242,AJ292075,AJ311599,AK000042,AK002121,AK023512,AK025772,AK026672,AK026923,AK027260,AK027811,AL110265,AL136756,AY012155,AY014902,BAB22930,BAB23396,BC001399,BC002591,BC002601,BC002666,BC004983,BC007858,BC009401,BC010954,D28137,D30755,D32129,D37766,D83957,D90034,J03909,J04080,L36591,M14648,M16006,M21533,M24097,M24283,M29696,M30818,M33882,M37435,M37719,M55542,M59465,M59807,M60335,M73255,M87284,M92357,S71513,U13697,U46573,U64197,U66096,U67784,U81234,U84487,X02661,X03557,X04327,X04371,X05232,X06820,X53799,X53800,X65965,X71087,X79089,X99886,Y12653,Y13582,Y16645,Z14136,Z24724
GENE_SYMBOLS	,,OXR1,IFI44L,LGALS9,SAMHD1,ICOSLG,SLC15A3,PDGFRL,DENND11,NCEH1,OAS3,RAC3,APOL1,RIPK2,PLA1A,TLR2,BIRC3,IFIH1,LIPG,UBD,HSD17B11,C1QTNF1,CXCL8,DNAJA1,HLA-B,HLA-B,DDX60,DRAM1,SPAG9,RABL3,SAMD9L,ANO9,PARP14,SAMHD1,SMAD3,SSPN,TNIP1,APOL3,CTHRC1,CMPK2,FTH1,MMP10,NFKBIA,GBP1,NFKBIA,INHBA,IL32,CXCL10,BST2,TNIP1,HLA-A,LAMB3,HLA-C,,,C1S,HLA-B,ITGAV,SERPINE1,HLA-E,HLA-C,ICAM1,IL7R,MX2,MX1,CSF1,CCL2,GBP1,TNFAIP3,IL32,VCAM1,VCAM1,OAS2,TNFAIP2,CCL2,CASP1,CCL11,CCL20,CXCL11,ACKR3,CXCL6,CX3CL1,OAS1,IFIT1,BPGM,OAS1,MMP3,RHOB,CXCL2,CXCL3,SOD2,CCL7,LGALS3BP,CCL8,UBD,TAPBP,CCL8,SAT1,ATP13A3
FOUNDER_NAMES