STANDARD_NAME	SASAKI_TARGETS_OF_TP73_AND_TP63
SYSTEMATIC_NAME	M17374
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/SASAKI_TARGETS_OF_TP73_AND_TP63
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in DLD1 cells (colon cancer) by p73 beta [GeneID=7161] or by and p63 gamma [GeneID=8626] but not by p53 [GeneID=7157].
DESCRIPTION_FULL	p63 and p73 show a high degree of structural homology to p53 and are members of a family of transcriptional factors that can activate transcription of p53-responsive genes. p53 is mutated in more than 50% of human cancers, whereas p63 and p73 are rarely mutated. Studies of knockout mice also revealed an unexpected functional diversity among the p53 family. To determine how p63 and p73 are involved in tumorigenesis and normal development, we used cDNA microarray to examine 9216 genes in human colorectal cancer cells. We discovered that the expression of pigment epithelium-derived factor (PEDF) was specifically induced by either p63 or p73, but not by p53. We also report here that the PEDF gene contains a response element specific for p63 and p73 in its promoter region and is a direct target of p63 and p73. Collectively, p63 and p73 may be involved in cell fate by inducing PEDF expression.
PMID	15856012
GEOID	
AUTHORS	Sasaki Y,Naishiro Y,Oshima Y,Imai K,Nakamura Y,Tokino T
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ATDC,CYR61,IL4R,ITGB1,JAG1,JAG2,MT1H,MT1X,MT2A,PEDF,PYST2,RSRFR2
GENE_SYMBOLS	ATM,CCN1,IL4R,ITGB1,JAG1,JAG2,MT1H,MT1X,MT2A,SERPINF1,DUSP7,MEF2B
FOUNDER_NAMES