STANDARD_NAME	SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER
SYSTEMATIC_NAME	M11288
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER
NAMESPACE	Human_NCBI_Gene_ID
DESCRIPTION_BRIEF	Genes bearing H3K27me3 mark or whose promoters are bound by the polycomb proteins SUZ12 or EED [GeneID=23512;8726]; their DNA is methylated de novo in cancer.
DESCRIPTION_FULL	Many genes associated with CpG islands undergo de novo methylation in cancer. Studies have suggested that the pattern of this modification may be partially determined by an instructive mechanism that recognizes specifically marked regions of the genome. Using chromatin immunoprecipitation analysis, here we show that genes methylated in cancer cells are specifically packaged with nucleosomes containing histone H3 trimethylated on Lys27. This chromatin mark is established on these unmethylated CpG island genes early in development and then maintained in differentiated cell types by the presence of an EZH2-containing Polycomb complex. In cancer cells, as opposed to normal cells, the presence of this complex brings about the recruitment of DNA methyl transferases, leading to de novo methylation. These results suggest that tumor-specific targeting of de novo methylation is pre-programmed by an established epigenetic system that normally has a role in marking embryonic genes for repression.
PMID	17200670
GEOID	
AUTHORS	Schlesinger Y,Straussman R,Keshet I,Farkash S,Hecht M,Zimmerman J,Eden E,Yakhini Z,Ben-Shushan E,Reubinoff BE,Bergman Y,Simon I,Cedar H
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 4S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1002,1012,1031,10395,10397,1045,10481,1052,10912,11035,116362,1396,140628,1594,1630,1825,1848,1960,2108,2200,2304,23368,257,26257,2626,2706,2719,27328,2778,283212,29108,3039,3090,3170,320,353174,3725,3784,3909,3958,40,4489,4504,4654,4824,4884,4915,5079,5080,5081,51352,5241,5376,5453,5592,5744,5827,5914,59271,5950,596,6387,6422,6425,6585,6899,6926,7022,7026,7056,7161,7421,7490,796,79852,81693,83593,84634,8718,8739,8744,8900,8913,91851,9314,9338,960,9638
GENE_SYMBOLS	CDH4,CDH13,CDKN2C,DLC1,NDRG1,CDX2,HOXB13,CEBPD,GADD45G,RIPK3,RBP7,CRIP1,GATA5,CYP27B1,DCC,DSC3,DUSP6,EGR3,ETFA,FBN1,FOXE1,PPP1R13B,ALX3,NKX2-8,GATA4,GJB2,GPC3,PCDH11X,GNAS,KLHL35,PYCARD,HBA1,HIC1,FOXA2,APBA1,ZACN,JUN,KCNQ1,LAMA3,LGALS3,ASIC2,MT1A,MT3,MYOD1,NKX3-1,NPTX1,NTRK2,PAX5,PAX6,PAX7,WT1-AS,PGR,PMP22,POU3F1,PRKG1,PTHLH,PXMP2,RARA,EVA1C,RBP4,BCL2,CXCL12,SFRP1,SFRP5,SLIT1,TBX1,TBX3,TFAP2C,NR2F2,THBD,TP73,VDR,WT1,CALCA,EPHX3,AMN,RASSF5,KISS1R,TNFRSF25,HRK,TNFSF9,CCNA1,CACNA1G,CHRDL1,KLF4,TCEAL1,CD44,FEZ1
FOUNDER_NAMES