STANDARD_NAME	SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP
SYSTEMATIC_NAME	M7284
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Genes up-regulated in CT60/4 cells (breast cancer reverted to normal by transfer of chromosome 8p region) vs parental MDA-MB-231 cells (deleted chromosome 8p).
DESCRIPTION_FULL	Several investigations have supposed that tumor suppressor genes might be located on human chromosome 8. We used microcell-mediated transfer of chromosome 8 into MDA-MB-231 breast cancer cells and generated independent hybrids with strongly reduced tumorigenic potential. Loss of the transferred chromosome results in reappearance of the malignant phenotype. Expression analysis identified a set of 109 genes (CT8-ps) differentially expressed in microcell hybrids as compared to the tumorigenic MDA-MB-231 and rerevertant cells. Of these, 44.9% are differentially expressed in human breast tumors. The expression pattern of CT8-ps was associated with prognostic factors such as tumor size and grading as well as loss of heterozygosity at the short arm of chromosome 8. We identified CT8-ps networks suggesting that these genes act cooperatively to cause reversion of tumorigenicity in MDA-MB-231 cells. Our findings provide a conceptual basis and experimental system to identify and evaluate genes and gene networks involved in the development and/or progression of breast cancer.
PMID	15580292
GEOID	
AUTHORS	Seitz S,Frege R,Jacobsen A,Weimer J,Arnold W,von Haefen C,Niederacher D,Schmutzler R,Arnold N,Scherneck S
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S: Log Ratio CT60/4 vs. MDA-MB-231 > 0
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1405_i_at,201147_s_at,201148_s_at,201149_s_at,201150_s_at,201368_at,201563_at,201565_s_at,201566_x_at,201695_s_at,202086_at,202269_x_at,202363_at,202403_s_at,202411_at,202501_at,202669_s_at,203108_at,203153_at,203180_at,203851_at,204070_at,204439_at,204532_x_at,204533_at,204655_at,204698_at,204747_at,204897_at,204972_at,204994_at,205009_at,205034_at,205433_at,205466_s_at,205483_s_at,205552_s_at,205660_at,206022_at,206023_at,206094_x_at,206805_at,206932_at,207126_x_at,208268_at,208596_s_at,208650_s_at,208791_at,208792_s_at,209373_at,209466_x_at,209505_at,209735_at,209771_x_at,209897_s_at,209942_x_at,210029_at,210163_at,210797_s_at,211122_s_at,211518_s_at,211737_x_at,211742_s_at,211814_s_at,212560_at,213684_s_at,214321_at,214453_s_at,214612_x_at,215125_s_at,216060_s_at,216379_x_at,217502_at,217766_s_at,218943_s_at,218986_s_at,219181_at,219209_at,219352_at,219403_s_at,219449_s_at,219691_at,219863_at,220014_at,220104_at,220266_s_at,221060_s_at,221305_s_at,221541_at,221766_s_at,221841_s_at,222043_at,222227_at,266_s_at,33304_at,823_at
GENE_SYMBOLS	CCL5,TIMP3,TIMP3,TIMP3,TIMP3,ZFP36L2,SORD,ID2,,PNP,MX1,GBP1,SPOCK1,COL1A2,IFI27,MAPRE2,EFNB2,GPRC5A,IFIT1,ALDH1A3,IGFBP6,PLAAT4,IFI44L,UGT1A10,CXCL10,CCL5,ISG20,IFIT3,PTGER4,OAS2,MX2,TFF1,CCNE2,BCHE,HS3ST1,ISG15,OAS1,OASL,NDP,NMU,UGT1A10,SEMA3A,CH25H,UGT1A10,ADAM28,UGT1A10,CD24P2,CLU,CLU,MALL,PTN,NR2F1,ABCG2,CD24,SLIT2,MAGEA3,IDO1,,OASL,CXCL11,BMP4,PTN,EVI2B,CCNE2,SORL1,PDLIM5,CCN3,IFI44,MAGEA3,UGT1A10,DAAM1,CD24,IFIT2,TMEM50A,RIGI,DDX60,LIPG,IFIH1,HERC6,HPSE,TMEM70,SAMD9,HERC5,PRR16,ZC3HAV1,KLF4,TLR4,UGT1A8,CRISPLD2,TENT5A,KLF4,CLU,,CD24,ISG20,CX3CL1
FOUNDER_NAMES