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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP" SYSTEMATIC_NAME="M7284" HISTORICAL_NAMES="" PMID="15580292" AUTHORS="Seitz S,Frege R,Jacobsen A,Weimer J,Arnold W,von Haefen C,Niederacher D,Schmutzler R,Arnold N,Scherneck S" GEOID="" EXACT_SOURCE="Table 1S: Log Ratio CT60/4 vs. MDA-MB-231 &gt; 0" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_HG_U133" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes up-regulated in CT60/4 cells (breast cancer reverted to normal by transfer of chromosome 8p region) vs parental MDA-MB-231 cells (deleted chromosome 8p)." DESCRIPTION_FULL="Several investigations have supposed that tumor suppressor genes might be located on human chromosome 8. We used microcell-mediated transfer of chromosome 8 into MDA-MB-231 breast cancer cells and generated independent hybrids with strongly reduced tumorigenic potential. Loss of the transferred chromosome results in reappearance of the malignant phenotype. Expression analysis identified a set of 109 genes (CT8-ps) differentially expressed in microcell hybrids as compared to the tumorigenic MDA-MB-231 and rerevertant cells. Of these, 44.9% are differentially expressed in human breast tumors. The expression pattern of CT8-ps was associated with prognostic factors such as tumor size and grading as well as loss of heterozygosity at the short arm of chromosome 8. We identified CT8-ps networks suggesting that these genes act cooperatively to cause reversion of tumorigenicity in MDA-MB-231 cells. Our findings provide a conceptual basis and experimental system to identify and evaluate genes and gene networks involved in the development and/or progression of breast cancer." TAGS="" MEMBERS="1405_i_at,201147_s_at,201148_s_at,201149_s_at,201150_s_at,201368_at,201563_at,201565_s_at,201566_x_at,201695_s_at,202086_at,202269_x_at,202363_at,202403_s_at,202411_at,202501_at,202669_s_at,203108_at,203153_at,203180_at,203851_at,204070_at,204439_at,204532_x_at,204533_at,204655_at,204698_at,204747_at,204897_at,204972_at,204994_at,205009_at,205034_at,205433_at,205466_s_at,205483_s_at,205552_s_at,205660_at,206022_at,206023_at,206094_x_at,206805_at,206932_at,207126_x_at,208268_at,208596_s_at,208650_s_at,208791_at,208792_s_at,209373_at,209466_x_at,209505_at,209735_at,209771_x_at,209897_s_at,209942_x_at,210029_at,210163_at,210797_s_at,211122_s_at,211518_s_at,211737_x_at,211742_s_at,211814_s_at,212560_at,213684_s_at,214321_at,214453_s_at,214612_x_at,215125_s_at,216060_s_at,216379_x_at,217502_at,217766_s_at,218943_s_at,218986_s_at,219181_at,219209_at,219352_at,219403_s_at,219449_s_at,219691_at,219863_at,220014_at,220104_at,220266_s_at,221060_s_at,221305_s_at,221541_at,221766_s_at,221841_s_at,222043_at,222227_at,266_s_at,33304_at,823_at" MEMBERS_SYMBOLIZED="ABCG2,ADAM28,ALDH1A3,BCHE,BMP4,CCL5,CCN3,CCNE2,CD24,CD24P2,CH25H,CLU,COL1A2,CRISPLD2,CX3CL1,CXCL10,CXCL11,DAAM1,DDX60,EFNB2,EVI2B,GBP1,GPRC5A,HERC5,HERC6,HPSE,HS3ST1,ID2,IDO1,IFI27,IFI44,IFI44L,IFIH1,IFIT1,IFIT2,IFIT3,IGFBP6,ISG15,ISG20,KLF4,LIPG,MAGEA3,MALL,MAPRE2,MX1,MX2,NDP,NMU,NR2F1,OAS1,OAS2,OASL,PDLIM5,PLAAT4,PNP,PRR16,PTGER4,PTN,RIGI,SAMD9,SEMA3A,SLIT2,SORD,SORL1,SPOCK1,TENT5A,TFF1,TIMP3,TLR4,TMEM50A,TMEM70,UGT1A10,UGT1A8,ZC3HAV1,ZFP36L2" MEMBERS_EZID="100133941,10371,10561,10611,10855,10863,10874,10964,10982,1191,1278,1948,2124,220,23002,23585,23586,2633,3398,3429,3433,3434,3437,3489,3620,3627,3669,4102,4599,4600,4693,4856,4860,4938,4939,51191,51334,54575,54576,54809,54968,55008,55601,55603,56829,5734,5764,590,5920,6352,6373,6376,64135,652,6652,6653,6695,678,7025,7031,7078,7099,7851,83716,8638,9023,9052,9134,9314,9353,936,9388,9429,9636,9957" MEMBERS_MAPPING="1405_i_at,CCL5,6352|201147_s_at,TIMP3,7078|201148_s_at,TIMP3,7078|201149_s_at,TIMP3,7078|201150_s_at,TIMP3,7078|201368_at,ZFP36L2,678|201563_at,SORD,6652|201565_s_at,ID2,3398|201566_x_at,null,null|201695_s_at,PNP,4860|202086_at,MX1,4599|202269_x_at,GBP1,2633|202363_at,SPOCK1,6695|202403_s_at,COL1A2,1278|202411_at,IFI27,3429|202501_at,MAPRE2,10982|202669_s_at,EFNB2,1948|203108_at,GPRC5A,9052|203153_at,IFIT1,3434|203180_at,ALDH1A3,220|203851_at,IGFBP6,3489|204070_at,PLAAT4,5920|204439_at,IFI44L,10964|204532_x_at,UGT1A10,54575|204533_at,CXCL10,3627|204655_at,CCL5,6352|204698_at,ISG20,3669|204747_at,IFIT3,3437|204897_at,PTGER4,5734|204972_at,OAS2,4939|204994_at,MX2,4600|205009_at,TFF1,7031|205034_at,CCNE2,9134|205433_at,BCHE,590|205466_s_at,HS3ST1,9957|205483_s_at,ISG15,9636|205552_s_at,OAS1,4938|205660_at,OASL,8638|206022_at,NDP,4693|206023_at,NMU,10874|206094_x_at,UGT1A10,54575|206805_at,SEMA3A,10371|206932_at,CH25H,9023|207126_x_at,UGT1A10,54575|208268_at,ADAM28,10863|208596_s_at,UGT1A10,54575|208650_s_at,CD24P2,936|208791_at,CLU,1191|208792_s_at,CLU,1191|209373_at,MALL,7851|209466_x_at,PTN,5764|209505_at,NR2F1,7025|209735_at,ABCG2,9429|209771_x_at,CD24,100133941|209897_s_at,SLIT2,9353|209942_x_at,MAGEA3,4102|210029_at,IDO1,3620|210163_at,null,null|210797_s_at,OASL,8638|211122_s_at,CXCL11,6373|211518_s_at,BMP4,652|211737_x_at,PTN,5764|211742_s_at,EVI2B,2124|211814_s_at,CCNE2,9134|212560_at,SORL1,6653|213684_s_at,PDLIM5,10611|214321_at,CCN3,4856|214453_s_at,IFI44,10561|214612_x_at,MAGEA3,4102|215125_s_at,UGT1A10,54575|216060_s_at,DAAM1,23002|216379_x_at,CD24,100133941|217502_at,IFIT2,3433|217766_s_at,TMEM50A,23585|218943_s_at,RIGI,23586|218986_s_at,DDX60,55601|219181_at,LIPG,9388|219209_at,IFIH1,64135|219352_at,HERC6,55008|219403_s_at,HPSE,10855|219449_s_at,TMEM70,54968|219691_at,SAMD9,54809|219863_at,HERC5,51191|220014_at,PRR16,51334|220104_at,ZC3HAV1,56829|220266_s_at,KLF4,9314|221060_s_at,TLR4,7099|221305_s_at,UGT1A8,54576|221541_at,CRISPLD2,83716|221766_s_at,TENT5A,55603|221841_s_at,KLF4,9314|222043_at,CLU,1191|222227_at,null,null|266_s_at,CD24,100133941|33304_at,ISG20,3669|823_at,CX3CL1,6376" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
