STANDARD_NAME	SHARMA_PILOCYTIC_ASTROCYTOMA_LOCATION_DN
SYSTEMATIC_NAME	M19757
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/SHARMA_PILOCYTIC_ASTROCYTOMA_LOCATION_DN
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Genes down-regulated in pilocytic astrocytoma (PA) from supratentorial regions compared to the infratentorial PA tumors.
DESCRIPTION_FULL	Pilocytic astrocytomas (PAs) are the most common glioma in children. Whereas many PAs are slow-growing or clinically indolent, others exhibit more aggressive features with tumor recurrence and death. To identify genetic signatures that might predict PA clinical behavior, we did gene expression profiling on 41 primary PAs arising sporadically and in patients with neurofibromatosis type 1 (NF1). Whereas no expression signature was found that could discriminate clinically aggressive or recurrent tumors from more indolent cases, PAs arising in patients with NF1 did exhibit a unique gene expression pattern. In addition, we identified a gene expression signature that stratified PAs by location (supratentorial versus infratentorial). Lastly, we also identified a gene expression pattern common to PAs and normal mouse astrocytes and neural stem cells from these distinct brain regions as well as a gene expression pattern shared between PAs and another human glial tumor (ependymoma) arising supratentorially compared with those originating in the posterior fossa. These results suggest that glial tumors share an intrinsic, lineage-specific molecular signature that reflects the brain region in which their nonmalignant predecessors originated.
PMID	17283119
GEOID	GSE5675
AUTHORS	Sharma MK,Mansur DB,Reifenberger G,Perry A,Leonard JR,Aldape KD,Albin MG,Emnett RJ,Loeser S,Watson MA,Nagarajan R,Gutmann DH
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1: SAM score < 0
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1553485_at,1553972_a_at,203185_at,210239_at,212561_at,212816_s_at,216059_at,228462_at,230463_at,231666_at,243879_at
GENE_SYMBOLS	CCDC140,CBS,RASSF2,IRX5,DENND5A,CBS,PAX3,IRX2,,PAX3,
FOUNDER_NAMES