STANDARD_NAME	SMID_BREAST_CANCER_RELAPSE_IN_PLEURA_DN
SYSTEMATIC_NAME	M2118
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/SMID_BREAST_CANCER_RELAPSE_IN_PLEURA_DN
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Genes down-regulated in pleura relapse of breast cancer.
DESCRIPTION_FULL	We explored whether the five previously reported molecular subtypes in breast cancer show a preference for organ-specific relapse and searched for molecular pathways involved. The intrinsic gene list describing the subtypes was used to classify 344 primary breast tumors of lymph node-negative patients. Fisher exact tests were used to determine the association between a tumor subtype and a particular site of distant relapse in these patients who only received local treatment. Modulated genes and pathways were identified in the various groups using Significance Analysis of Microarrays and Global Testing. Bone relapse patients were most abundant in the luminal subtypes but were found less than expected in the basal subtype. The reverse was true for lung and brain relapse patients with the remark that absence of lung relapse was luminal A specific. Finally, a pleura relapse, although rare, was found almost exclusively in both luminal subtypes. Many differentially expressed genes were identified, of which several were in common in a subtype and the site to which the subtype preferentially relapsed. WNT signaling was up-regulated in the basal subtype and in brain-specific relapse, and down-modulated in the luminal B subtype and in bone-specific relapse. Focal adhesion was found up-regulated in the luminal A subtype but down-regulated in lung relapse. The five major molecular subtypes in breast cancer are evidently different with regard to their ability to metastasize to distant organ(s), and share biological features and pathways with their preferred distant metastatic site.
PMID	18451135
GEOID	GSE2034,GSE5327
AUTHORS	Smid M,Wang Y,Zhang Y,Sieuwerts AM,Yu J,Klijn JG,Foekens JA,Martens JW
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Fig 1S: pleura down
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	202018_s_at,203021_at,203256_at,203304_at,203535_at,203915_at,204351_at,204675_at,204846_at,205030_at,205285_s_at,205817_at,205890_s_at,205916_at,206224_at,206560_s_at,206774_at,209498_at,209823_x_at,209924_at,209942_x_at,211056_s_at,211644_x_at,211645_x_at,212094_at,214186_s_at,215176_x_at,216207_x_at,216557_x_at,219010_at,219270_at,219926_at,220892_s_at
GENE_SYMBOLS	LTF,SLPI,CDH3,BAMBI,S100A9,CXCL9,S100P,SRD5A1,CP,FABP7,FYB1,SIX1,GABBR1,S100A7,CST1,MIA,FRMPD1,CEACAM1,HLA-DQB1,CCL18,MAGEA3,SRD5A1,IGKV3-20,IGKV1D-17,PEG10,HCP5,IGKV1D-39,IGKV1D-13,IGHV3-21,INAVA,CHAC1,POPDC3,PSAT1
FOUNDER_NAMES