STANDARD_NAME SMIRNOV_RESPONSE_TO_IR_6HR_DN SYSTEMATIC_NAME M2590 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/SMIRNOV_RESPONSE_TO_IR_6HR_DN NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes down-regulated in B lymphocytes at 6 h after exprosure to 10 Gy dose of ionizing radiation. DESCRIPTION_FULL Radiation exposure through environmental, medical, and occupational settings is increasingly common. While radiation has harmful effects, it has utility in many applications such as radiotherapy for cancer. To increase the efficacy of radiation treatment and minimize its risks, a better understanding of the individual differences in radiosensitivity and the molecular basis of radiation response is needed. Here, we integrated human genetic and functional genomic approaches to study the response of human cells to radiation. We measured radiation-induced changes in gene expression and cell death in B cells from normal individuals. We found extensive individual variation in gene expression and cellular responses. To understand the genetic basis of this variation, we mapped the DNA sequence variants that influence expression response to radiation. We also identified radiation-responsive genes that regulate cell death; silencing of these genes by small interfering RNA led to an increase in radiation-induced cell death in human B cells, colorectal and prostate cancer cells. Together these results uncovered DNA variants that contribute to radiosensitivity and identified genes that can be targeted to increase the sensitivity of tumors to radiation. PMID 21844125 GEOID GSE26835 AUTHORS Smirnov DA,Brady L,Halasa K,Morley M,Solomon S,Cheung VG CONTRIBUTOR Itai Pashtan CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE Table 1S: Current Study 6hr avg log2 fold change =< -0.58 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 200832_s_at,200894_s_at,201531_at,201626_at,201627_s_at,201694_s_at,201848_s_at,201849_at,201896_s_at,201925_s_at,202068_s_at,202081_at,202240_at,202241_at,202388_at,202431_s_at,202498_s_at,202499_s_at,202769_at,202779_s_at,202855_s_at,202856_s_at,202870_s_at,202934_at,202954_at,202988_s_at,203520_s_at,203521_s_at,203764_at,203767_s_at,203923_s_at,204092_s_at,204103_at,204164_at,204206_at,204256_at,204352_at,204492_at,204581_at,204622_x_at,204641_at,204709_s_at,204774_at,204794_at,204805_s_at,204960_at,204962_s_at,204995_at,205046_at,205098_at,205213_at,205269_at,205484_at,205527_s_at,205544_s_at,205552_s_at,205884_at,205885_s_at,206039_at,206115_at,206364_at,206513_at,206653_at,206686_at,206975_at,206983_at,207113_s_at,207165_at,207238_s_at,207522_s_at,207543_s_at,207828_s_at,208079_s_at,208886_at,208961_s_at,209172_s_at,209473_at,209566_at,209642_at,209709_s_at,209795_at,209827_s_at,209829_at,209933_s_at,209995_s_at,210052_s_at,210279_at,210448_s_at,210821_x_at,210868_s_at,211080_s_at,211576_s_at,212144_at,212188_at,212192_at,212399_s_at,212587_s_at,212588_at,212689_s_at,212769_at,212977_at,213106_at,213416_at,213566_at,213772_s_at,213888_s_at,214710_s_at,214933_at,215509_s_at,215933_s_at,216248_s_at,217983_s_at,217984_at,218149_s_at,218507_at,218723_s_at,218755_at,219232_s_at,219371_s_at,219410_at,219806_s_at,219812_at,219821_s_at,219918_s_at,220118_at,220132_s_at,220295_x_at,220494_s_at,221436_s_at,221497_x_at,221823_at,222088_s_at,36711_at,38521_at,39318_at,40472_at,44783_s_at GENE_SYMBOLS SCD,FKBP4,ZFP36,INSIG1,INSIG1,EGR1,BNIP3,BNIP3,PSRC1,CD55,LDLR,IER2,PLK1,TRIB1,RGS2,MYC,SLC2A3,SLC2A3,CCNG2,UBE2S,SLC16A3,SLC16A3,CDC20,HK2,UBE2C,RGS1,ZNF318,ZNF318,DLGAP5,STS,CYBB,AURKA,CCL4,SIPA1,MNT,ELOVL6,TRAF5,ARHGAP11A,CD22,NR4A2,NEK2,KIF23,EVI2A,DUSP2,H1-10,PTPRCAP,CENPA,CDK5R1,CENPE,CCR1,ACAP1,LCP2,SIT1,GEMIN4,CR2,OAS1,ITGA4,ITGA4,RAB33A,EGR3,KIF14,AIM2,POLR3G,PDK1,LTA,CCR6,TNF,HMMR,PTPRC,ATP2A3,P4HA1,CENPF,AURKA,H1-0,KLF6,CENPF,ENTPD1,INSIG2,BUB1,HMMR,CD69,IL16,RIPOR2,CD300A,TCL1A,TPX2,GPR18,P2RX5,CENPA,ELOVL6,NEK2,SLC19A1,SUN2,KCTD12,KCTD12,VGLL4,PTPRC,PTPRC,KDM3A,TLE3,ACKR3,ATP8A1,ITGA4,RNASE6,GGA2,TRAF3IP3,CCNB1,CACNA1A,BUB1,HHEX,NR4A2,RNASET2,RNASET2,ZNF395,HILPDA,RGCC,KIF20A,EGLN3,KLF2,TMEM45A,SMCO4,PVRIG,GFOD1,ASPM,ZBTB32,CLEC2D,DEPDC1,,CDCA3,EGLN1,MACIR,SLC2A3,MAFF,CD22,TCL1A,LPCAT4,HEY1 FOUNDER_NAMES