STANDARD_NAME	SOBOLEV_T_CELL_PANDEMRIX_AGE_18_64YO_1DY_UP
SYSTEMATIC_NAME	M41207
COLLECTION	C7:VAX
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/SOBOLEV_T_CELL_PANDEMRIX_AGE_18_64YO_1DY_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in T cell 1d vs 0d in adults (18-64) after exposure to Pandemrix (A/California/7/09 (H1N1)) , time point 1D. Comment: - roughly 60/40 female:male ratio, over 70% were Causasian
DESCRIPTION_FULL	Adjuvanted vaccines afford invaluable protection against disease, and the molecular and cellular changes they induce offer direct insight into human immunobiology. Here we show that within 24 h of receiving adjuvanted swine flu vaccine, healthy individuals made expansive, complex molecular and cellular responses that included overt lymphoid as well as myeloid contributions. Unexpectedly, this early response was subtly but significantly different in people older than ~35 years. Wide-ranging adverse clinical events can seriously confound vaccine adoption, but whether there are immunological correlates of these is unknown. Here we identify a molecular signature of adverse events that was commonly associated with an existing B cell phenotype. Thus immunophenotypic variation among healthy humans may be manifest in complex pathophysiological responses.
PMID	26726811
GEOID	
AUTHORS	Sobolev O,Binda E,O'Farrell S,Lorenc A,Pradines J,Huang Y,Duffner J,Schulz R,Cason J,Zambon M,Malim MH,Peakman M,Cope A,Capila I,Kaundinya GV,Hayday AC
CONTRIBUTOR	HIPC SIGNATURES
CONTRIBUTOR_ORG	NIAID/HIPC SIGNATURES
EXACT_SOURCE	Fig2c
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485475/figure/F2/
SOURCE_MEMBERS	CD247,CD3D,CD3E,CD3G,CD8A,CD8B,CXCL10,CXCL9,FYN,LAT,LCK,MAP4K1,NFATC1,NFATC2,NFATC3,PAG1,PLCG1,PRF1,PRKCQ,RASGRP1,RASGRP2,SLA2,ZAP70
GENE_SYMBOLS	CD247,CD3D,CD3E,CD3G,CD8A,CD8B,CXCL10,CXCL9,FYN,LAT,LCK,MAP4K1,NFATC1,NFATC2,NFATC3,PAG1,PLCG1,PRF1,PRKCQ,RASGRP1,RASGRP2,SLA2,ZAP70
FOUNDER_NAMES