STANDARD_NAME	SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_2FC_UP
SYSTEMATIC_NAME	M2267
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_2FC_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated more than two-fold in lymphoblastoid cell lines from European population compared to those from Asian population.
DESCRIPTION_FULL	Variation in DNA sequence contributes to individual differences in quantitative traits, but in humans the specific sequence variants are known for very few traits. We characterized variation in gene expression in cells from individuals belonging to three major population groups. This quantitative phenotype differs significantly between European-derived and Asian-derived populations for 1,097 of 4,197 genes tested. For the phenotypes with the strongest evidence of cis determinants, most of the variation is due to allele frequency differences at cis-linked regulators. The results show that specific genetic variation among populations contributes appreciably to differences in gene expression phenotypes. Populations differ in prevalence of many complex genetic diseases, such as diabetes and cardiovascular disease. As some of these are probably influenced by the level of gene expression, our results suggest that allele frequency differences at regulatory polymorphisms also account for some population differences in prevalence of complex diseases.
PMID	17206142
GEOID	GSE5859
AUTHORS	Spielman RS,Bastone LA,Burdick JT,Morley M,Ewens WJ,Cheung VG
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ARPC4,ATP8B1,COPG,D21S2056E,DPYSL2,FCER2,HDGFRP3,HSPB1,MEIS2,RGS20,ROBO1,STXBP2,TCF7,UGT2B17
GENE_SYMBOLS	ARPC4,ATP8B1,COPG1,RRP1,DPYSL2,FCER2,,HSPB1,MEIS2,RGS20,ROBO1,STXBP2,TCF7,UGT2B17
FOUNDER_NAMES