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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="STARK_HYPPOCAMPUS_22Q11_DELETION_DN" SYSTEMATIC_NAME="M17954" HISTORICAL_NAMES="" PMID="18469815" AUTHORS="Stark KL,Xu B,Bagchi A,Lai WS,Liu H,Hsu R,Wan X,Pavlidis P,Mills AA,Karayiorgou M,Gogos JA" GEOID="GSE10784" EXACT_SOURCE="Table 1S: HPC down" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_Mouse430" CONTRIBUTOR="Jessica Robertson" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes down-regulated in hyppocampus of mice carrying a hemizygotic microdeletion in the 22q11.2 region." DESCRIPTION_FULL="Individuals with 22q11.2 microdeletions show behavioral and cognitive deficits and are at high risk of developing schizophrenia. We analyzed an engineered mouse strain carrying a chromosomal deficiency spanning a segment syntenic to the human 22q11.2 locus. We uncovered a previously unknown alteration in the biogenesis of microRNAs (miRNAs) and identified a subset of brain miRNAs affected by the microdeletion. We provide evidence that the abnormal miRNA biogenesis emerges because of haploinsufficiency of the Dgcr8 gene, which encodes an RNA-binding moiety of the 'microprocessor' complex and contributes to the behavioral and neuronal deficits associated with the 22q11.2 microdeletion." TAGS="" MEMBERS="1416821_at,1416822_at,1417629_at,1417839_at,1418087_at,1418701_at,1419732_at,1421809_at,1421810_at,1422547_at,1422977_at,1423061_at,1428190_at,1428739_at,1428753_a_at,1432367_a_at,1434244_x_at,1435439_at,1436241_s_at,1436468_at,1436796_at,1438255_at,1441391_at,1448114_a_at,1448115_at,1448849_at,1448900_at,1449097_at,1449183_at,1450855_at,1452357_at,1452434_s_at,1455311_at,1457675_at" MEMBERS_SYMBOLIZED="ARVCF,C22orf39,CLDN5,COMT,DGCR2,DGCR6,DGCR8,ENHO,ESS2,FOXN3,GP1BB,HIRA,MRPL40,PRODH,RANBP1,RTN4R,SLC25A1,SNORA74A,TANGO2,TRMT2A,TXNRD2,UFD1,ZDHHC8" MEMBERS_EZID="10587,1112,128977,128989,1312,26821,27037,2812,29801,375704,421,54487,5625,5902,64976,65078,6576,7122,7290,7353,8214,8220,9993" MEMBERS_MAPPING="1416821_at,ESS2,8220|1416822_at,ESS2,8220|1417629_at,PRODH,5625|1417839_at,CLDN5,7122|1418087_at,UFD1,7353|1418701_at,COMT,1312|1419732_at,RTN4R,65078|1421809_at,DGCR2,9993|1421810_at,DGCR2,9993|1422547_at,RANBP1,5902|1422977_at,GP1BB,2812|1423061_at,ARVCF,421|1428190_at,SLC25A1,6576|1428739_at,ENHO,375704|1428753_a_at,DGCR6,8214|1432367_a_at,UFD1,7353|1434244_x_at,TRMT2A,27037|1435439_at,DGCR8,54487|1436241_s_at,HIRA,7290|1436468_at,ZDHHC8,29801|1436796_at,SNORA74A,26821|1438255_at,FOXN3,1112|1441391_at,null,null|1448114_a_at,TRMT2A,27037|1448115_at,TRMT2A,27037|1448849_at,MRPL40,64976|1448900_at,TANGO2,128989|1449097_at,TXNRD2,10587|1449183_at,COMT,1312|1450855_at,ARVCF,421|1452357_at,GP1BB,2812|1452434_s_at,DGCR6,8214|1455311_at,DGCR8,54487|1457675_at,C22orf39,128977" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
