STANDARD_NAME	TAN_CRC_NECROPTOSIS_RELATED_GENES
SYSTEMATIC_NAME	M50227
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/TAN_CRC_NECROPTOSIS_RELATED_GENES
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	The NRG (Necroptosis-Related Gene) signature is an 18-gene transcriptional model designed for the prognostic stratification and immunological profiling of colorectal cancer (CRC).
DESCRIPTION_FULL	The NRG signature effectively classifies patients into high-risk and low-risk categories based on a calculated risk score. The low-risk group is significantly associated with an   immune hot   phenotype, characterized by high infiltration of cytotoxic T cells, NK cells, and the upregulation of 14 HLA-related antigens, as well as higher immune checkpoint activity. The high-risk group reflects an   immune cold   microenvironment with lower overall immune and TIDE scores. The signature's prognostic accuracy was validated across three independent cohorts (TCGA-COAD, GSE38832, and GSE161158), where a nomogram integrating the NRG score with AJCC staging achieved an AUC of 0.811 for 5-year overall survival.
PMID	40959081
GEOID	
AUTHORS	Tan L,Wang S,Chang W,Zhang X,Deng R,Yan H,Zhu W,Wang H,Cai Y,Liu Z,Tan Y,Cui J
CONTRIBUTOR	Anthony Castanza
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	NRG Signature as provided in study abstract
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://doi.org/10.3389/fimmu.2025.1619749
SOURCE_MEMBERS	APOL6,ARL4C,BATF2,CTSB,CXCL10,CXCL13,CXCL9,DUSP27,EPHB2,GZMB,HES6,IRF1,IRF8,NLRC5,PAEP,PTGDR,TAP2,WFS1
GENE_SYMBOLS	APOL6,ARL4C,BATF2,CTSB,CXCL10,CXCL13,CXCL9,STYXL2,EPHB2,GZMB,HES6,IRF1,IRF8,NLRC5,PAEP,PTGDR,TAP2,WFS1
FOUNDER_NAMES