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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="TAN_CRC_NECROPTOSIS_RELATED_GENES" SYSTEMATIC_NAME="M50227" HISTORICAL_NAMES="" PMID="40959081" AUTHORS="Tan L,Wang S,Chang W,Zhang X,Deng R,Yan H,Zhu W,Wang H,Cai Y,Liu Z,Tan Y,Cui J" GEOID="" EXACT_SOURCE="NRG Signature as provided in study abstract" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://doi.org/10.3389/fimmu.2025.1619749" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Anthony Castanza" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="The NRG (Necroptosis-Related Gene) signature is an 18-gene transcriptional model designed for the prognostic stratification and immunological profiling of colorectal cancer (CRC)." DESCRIPTION_FULL="The NRG signature effectively classifies patients into high-risk and low-risk categories based on a calculated risk score. The low-risk group is significantly associated with an   immune hot   phenotype, characterized by high infiltration of cytotoxic T cells, NK cells, and the upregulation of 14 HLA-related antigens, as well as higher immune checkpoint activity. The high-risk group reflects an   immune cold   microenvironment with lower overall immune and TIDE scores. The signature's prognostic accuracy was validated across three independent cohorts (TCGA-COAD, GSE38832, and GSE161158), where a nomogram integrating the NRG score with AJCC staging achieved an AUC of 0.811 for 5-year overall survival." TAGS="" MEMBERS="APOL6,ARL4C,BATF2,CTSB,CXCL10,CXCL13,CXCL9,DUSP27,EPHB2,GZMB,HES6,IRF1,IRF8,NLRC5,PAEP,PTGDR,TAP2,WFS1" MEMBERS_SYMBOLIZED="APOL6,ARL4C,BATF2,CTSB,CXCL10,CXCL13,CXCL9,EPHB2,GZMB,HES6,IRF1,IRF8,NLRC5,PAEP,PTGDR,STYXL2,TAP2,WFS1" MEMBERS_EZID="10123,10563,116071,1508,2048,3002,3394,3627,3659,4283,5047,55502,5729,6891,7466,80830,84166,92235" MEMBERS_MAPPING="APOL6,APOL6,80830|ARL4C,ARL4C,10123|BATF2,BATF2,116071|CTSB,CTSB,1508|CXCL10,CXCL10,3627|CXCL13,CXCL13,10563|CXCL9,CXCL9,4283|DUSP27,STYXL2,92235|EPHB2,EPHB2,2048|GZMB,GZMB,3002|HES6,HES6,55502|IRF1,IRF1,3659|IRF8,IRF8,3394|NLRC5,NLRC5,84166|PAEP,PAEP,5047|PTGDR,PTGDR,5729|TAP2,TAP2,6891|WFS1,WFS1,7466" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
