STANDARD_NAME	THEODOROU_MAMMARY_TUMORIGENESIS
SYSTEMATIC_NAME	M1291
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/THEODOROU_MAMMARY_TUMORIGENESIS
NAMESPACE	MOUSE_GENE_SYMBOL
DESCRIPTION_BRIEF	Candidate mammary tumorigenesis genes from the common insertion sites (CIS) of MMTV virus that induced breast tumors in mice.
DESCRIPTION_FULL	We performed a high-throughput retroviral insertional mutagenesis screen in mouse mammary tumor virus (MMTV)-induced mammary tumors and identified 33 common insertion sites, of which 17 genes were previously not known to be associated with mammary cancer and 13 had not previously been linked to cancer in general. Although members of the Wnt and fibroblast growth factors (Fgf) families were frequently tagged, our exhaustive screening for MMTV insertion sites uncovered a new repertoire of candidate breast cancer oncogenes. We validated one of these genes, Rspo3, as an oncogene by overexpression in a p53-deficient mammary epithelial cell line. The human orthologs of the candidate oncogenes were frequently deregulated in human breast cancers and associated with several tumor parameters. Computational analysis of all MMTV-tagged genes uncovered specific gene families not previously associated with cancer and showed a significant overrepresentation of protein domains and signaling pathways mainly associated with development and growth factor signaling. Comparison of all tagged genes in MMTV and Moloney murine leukemia virus-induced malignancies showed that both viruses target mostly different genes that act predominantly in distinct pathways.
PMID	17468756
GEOID	
AUTHORS	Theodorou V,Kimm MA,Boer M,Wessels L,Theelen W,Jonkers J,Hilkens J
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	Astn2,Atp2b1,Centg2,Dpp10,Egr3,Eras,Fgf10,Fgf3,Fgf4,Fgf6,Fgf8,Fgfr2,Foxc2,Gse1,Igf2,Jmjd1c,Klf15,Lamb1,Map3k8,Nkd2,Notch4,Odz1,Pdgfrb,Pros1,Ptgis,Rreb1,Rspo2,Rspo3,Sfmbt2,Wnt1,Wnt3
GENE_SYMBOLS	ASTN2,ATP2B1,AGAP1,DPP10,EGR3,ERAS,FGF10,FGF3,FGF4,FGF6,FGF8,FGFR2,FOXC2,GSE1,IGF2,JMJD1C,KLF15,LAMB1,MAP3K8,NKD2,NOTCH4,TENM1,PDGFRB,PROS1,PTGIS,RREB1,RSPO2,RSPO3,SFMBT2,WNT1,WNT3
FOUNDER_NAMES