STANDARD_NAME	TOMIDA_METASTASIS_UP
SYSTEMATIC_NAME	M17830
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/TOMIDA_METASTASIS_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Up-regulated genes associated with the acquision of metastatic potential in LNM35 cells (large cell lung cancer).
DESCRIPTION_FULL	Although widespread metastasis is the major cause of human lung cancer-related deaths, its underlying mechanism remains largely unclear. Our genome-wide comparison of the expression profiles of a highly metastatic lung cancer cell line, NCI-H460-LNM35 (LNM35), and its parental clone, NCI-H460-N15 (N15), resulted in the identification of a cancer metastasis signature composed of 45 genes. Through gene ontology analysis, our study also provided insights into how this 45-gene metastasis signature may contribute to the acquisition of metastatic potential. By applying the signature to datasets of human cancer cases, we could demonstrate significant associations with a subset of cases with poor prognosis not only for the two datasets of cancers of the lung but also for cancers of the breast. Furthermore, we were able to show that enforced expression of the DLX4 homeobox gene, which was identified as a gene with significant downregulation in LNM35 as well as with significant association with favorable prognosis for lung cancer patients, markedly inhibited in vitro motility and invasion as well as in vivo metastasis via both hematogenous and lymphogenous routes. Taken together, these findings indicate that our combined transcriptome analysis is an efficient approach in the search for genes possessing both clinical usefulness in terms of prognostic prediction in human cancer cases and clear functional relevance for studying cancer biology in relation to metastasis.
PMID	17260014
GEOID	GSE4705
AUTHORS	Tomida S,Yanagisawa K,Koshikawa K,Yatabe Y,Mitsudomi T,Osada H,Takahashi T
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ALG3,CKAP4,CPLX2,CXCL1,DAD1,DNER,ECH1,GNAI2,GNAS,HNRPA3,HNRPUL1,HSPCB,IER3,METAP2,MRPS22,PSMD2,PTTG1,SLC16A9,SNRPF,TFAP2A,TMSB4X,TUBA1,TUBA2,TUBA3D,TUBB,UBE1
GENE_SYMBOLS	ALG3,CKAP4,CPLX2,CXCL1,DAD1,DNER,ECH1,GNAI2,GNAS,HNRNPA3P1,HNRNPUL1,HSP90AB1,IER3,METAP2,MRPS22,PSMD2,PTTG1,SLC16A9,SNRPF,TFAP2A,TMSB4X,TUBA4A,TUBA3C,TUBA3D,TUBB,UBA1
FOUNDER_NAMES