STANDARD_NAME TSUNODA_CISPLATIN_RESISTANCE_UP SYSTEMATIC_NAME M10202 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/TSUNODA_CISPLATIN_RESISTANCE_UP NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF Genes up-regulated in bladder cancer cells resistant to cisplatin [PubChem=2767] compared to the parental cells sensitive to the drug. DESCRIPTION_FULL To investigate the molecules that regulate the acquisition of cis-diamminedichloroplatinum (II) (cisplatin) resistance, we performed cDNA microarrays using two pairs of parental and cisplatin-resistant bladder cancer cell lines. We found a markedly reduced expression of inositol 1,4,5-trisphosphate (IP3) receptor type1 (IP3R1), endoplasmic reticulum membrane protein, in cisplatin-resistant cells. The suppression of IP3R1 expression using small interfering RNA in parental cells prevented apoptosis and resulted in decreased sensitivity to cisplatin. Contrarily, overexpression of IP3R1 in resistant cells induced apoptosis and increased sensitivity to cisplatin. These results suggest that cisplatin-induced downregulation of IP3R1 expression was closely associated with the acquisition of cisplatin resistance in bladder cancer cells. PMID 15608674 GEOID AUTHORS Tsunoda T,Koga H,Yokomizo A,Tatsugami K,Eto M,Inokuchi J,Hirata A,Masuda K,Okumura K,Naito S CONTRIBUTOR Leona Saunders CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1, 2: Downregulated genes FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AA410508,AA451928,AF003594,AF007144,AV705672,AW072424,AW663903,BE877317,L20688,M15476,M18767,NM_006113,NM_006768,U03877,X78947 GENE_SYMBOLS UCA1,VIM,CCN1,DIO2,IFI27,NT5E,INSIG1,G0S2,ARHGDIB,PLAU,C1S,VAV3,BRAP,EFEMP1,CCN2 FOUNDER_NAMES