STANDARD_NAME UEDA_CENTRAL_CLOCK SYSTEMATIC_NAME M2637 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/UEDA_CENTRAL_CLOCK NAMESPACE AFFY_MG_U74 DESCRIPTION_BRIEF Molecular timetable composed of 96 time-indicating genes (103 probes) in the central (suprachiasmatic nucleus (SCN)) clock. DESCRIPTION_FULL Detection of individual body time (BT) via a single-time-point assay has been a longstanding unfulfilled dream in medicine, because BT information can be exploited to maximize potency and minimize toxicity during drug administration and thus will enable highly optimized medication. To achieve this dream, we created a molecular timetable composed of >100 time-indicating genes, whose gene expression levels can represent internal BT. Here we describe a robust method called the molecular-timetable method for BT detection from a single-time-point expression profile. The power of this method is demonstrated by the sensitive and accurate detection of BT and the sensitive diagnosis of rhythm disorders. These results demonstrate the feasibility of BT detection based on single-time-point sampling, suggest the potential for expression-based diagnosis of rhythm disorders, and may translate functional genomics into chronotherapy and personalized medicine. PMID 15273285 GEOID AUTHORS Ueda HR,Chen W,Minami Y,Honma S,Honma K,Iino M,Hashimoto S CONTRIBUTOR Kate Stafford CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 100566_at,100708_at,100946_at,101135_at,101381_at,101541_at,101889_s_at,101955_at,101975_at,101979_at,102081_at,102110_at,102140_at,102144_f_at,102292_at,102302_at,102382_at,102858_at,102955_at,103012_at,103029_at,103443_at,103683_at,103861_s_at,104139_at,104183_at,104598_at,104628_at,104682_at,160179_at,160182_at,160317_at,160330_at,160511_at,160841_at,161189_r_at,161235_f_at,161609_at,161666_f_at,162095_f_at,162198_f_at,92310_at,92487_at,92519_at,92532_at,92611_at,92767_at,92913_at,93013_at,93277_at,93325_at,93370_at,93381_at,93503_at,93619_at,93694_at,93868_at,93875_at,94034_at,94076_i_at,94207_at,94261_at,94274_at,94285_at,94322_at,94359_at,94378_at,94420_f_at,94761_at,94821_at,94872_at,95057_at,95418_at,95679_at,95704_at,95737_at,95749_at,95913_at,96041_at,96076_at,96114_at,96122_at,96216_at,96254_at,96266_at,96474_at,96653_at,96698_at,96954_at,97224_at,97890_at,98038_at,98055_at,98111_at,98149_s_at,98967_at,99032_at,99076_at,99100_at,99185_at,99363_at,99575_at,99815_at GENE_SYMBOLS IGFBP5,H3-3A,HSPA1B,CALCR,RABEP1,,RORA,HSPA5,DLK1,GADD45G,,,,,GADD45A,BCKDHB,BMAL1,PKIB,NFIL3,CCL21,PDCD4,CRYBG1,DHODH,UBFD1,P4HA1,TUBGCP4,DUSP1,MAN2A1,TUBA8,TMEM30A,SRSF6,RAB34,CHORDC1,CXCL12,DBP,,,,GADD45B,,,PLK2,SOX7,PHKA1,AVPR1A,CAPRIN1,BMPR1A,ABCD2,ID2,HSPD1,POLR2E,SYT17,AVP,SFRP2,PER1,PER2,NSDHL,HSPA1A,REXO2,RPN2,PDIA6,THRAP3,UBE2S,HLA-DRB5,SQLE,PLEKHA1,RGS16,CRY1,CCL7,XBP1,SMPDL3A,HERPUD1,RASL11B,CDK2AP2,AP1B1,TPRG1L,MANF,AKAP17A,RBM3,STX5,PPP1R1A,CMBL,ORMDL1,DNAJB1,HNRNPM,ZBTB14,RNASET2,PSMD5,STK24,,SGK1,HMGB3,BLCAP,HSPH1,,FABP7,RASD1,NR1D2,STAT3,MRPL41,,UBQLN1,HRH2 FOUNDER_NAMES