STANDARD_NAME	UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_MONOCYTE_DN
SYSTEMATIC_NAME	M48292
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_MONOCYTE_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes downregulated in Monocytes from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors
DESCRIPTION_FULL	Thirty-eight PBMC samples from 25 patients with IPF and 13 matched controls yielded 149,564 cells that segregated into 23 subpopulations. Classical monocytes were increased in progressive and stable IPF compared to controls (32.1%, 25.2%, 17.9%, respectively, p<0.05). Total lymphocytes were decreased in IPF vs controls, and in progressive vs stable IPF (52.6% vs 62.6%, p=0.035). Tregs were increased in progressive vs stable IPF (1.8% vs 1.1% of all PBMC, p=0.007), although not different than controls, and may be associated with decreased survival (P=0.009 in Kaplan-Meier analysis; P=0.069 after adjusting for age, sex, and baseline FVC). Flow cytometry analysis confirmed this finding in an independent cohort of IPF patients. Fraction of Tregs out of all T cells was also increased in two cohorts of lung scRNA-seq. CCL22 and CCL18, ligands for CCR4 and CCR8 Treg chemotaxis receptors, were increased in IPF. The single-cell atlas of the peripheral immune system in IPF, reveals an outcome-predictive increase in classical monocytes and Tregs, as well as evidence for a lung-blood immune recruitment axis involving CCL7 (for classical monocytes) and CCL18/CCL22 (for Tregs). (From Abstract)
PMID	38717443
GEOID	
AUTHORS	Unterman A,Zhao AY,Neumark N,Schupp JC,Ahangari F,Cosme C Jr,Sharma P,Flint J,Stein Y,Ryu C,Ishikawa G,Sumida TS,Gomez JL,Herazo-Maya JD,Dela Cruz CS,Herzog EL,Kaminski N
CONTRIBUTOR	Anthony Castanza
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	table_e5_degs_progressivevsstable2, avg_LogFC<0, p_val_adg<0.05
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACSL1,BCL2A1,CCL3,CCL3L1,CCL4,CCL4L2,CD83,CXCL2,CXCL3,CXCL8,G0S2,GNLY,HLA-DQA2,ICAM1,IL1B,NAMPT,NFKBIA,NFKBIZ,NLRP3,PLEK,RNF144B,SAMSN1,SOD2,THBS1,TMEM176A,TMEM176B,TNF,TNFAIP3
GENE_SYMBOLS	ACSL1,BCL2A1,CCL3,,CCL4,CCL4L2,CD83,CXCL2,CXCL3,CXCL8,G0S2,GNLY,HLA-DQA2,ICAM1,IL1B,NAMPT,NFKBIA,NFKBIZ,NLRP3,PLEK,RNF144B,SAMSN1,SOD2,THBS1,TMEM176A,TMEM176B,TNF,TNFAIP3
FOUNDER_NAMES