STANDARD_NAME VANOEVELEN_MYOGENESIS_SIN3A_TARGETS SYSTEMATIC_NAME M2524 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/VANOEVELEN_MYOGENESIS_SIN3A_TARGETS NAMESPACE MOUSE_GENE_SYMBOL DESCRIPTION_BRIEF Loci bound exclusively by SIN3A [GeneID=25942] in myotubules. DESCRIPTION_FULL The highly related mammalian Sin3A and Sin3B proteins provide a versatile platform for chromatin-modifying activities. Sin3-containing complexes play a role in gene repression through deacetylation of nucleosomes. Here, we explore a role for Sin3 in myogenesis by examining the phenotypes resulting from acute somatic deletion of both isoforms in vivo and from primary myotubes in vitro. Myotubes ablated for Sin3A alone, but not Sin3B, displayed gross defects in sarcomere structure that were considerably enhanced upon simultaneous ablation of both isoforms. Massively parallel sequencing of Sin3A- and Sin3B-bound genomic loci revealed a subset of target genes directly involved in sarcomere function that are positively regulated by Sin3A and Sin3B proteins. Both proteins were coordinately recruited to a substantial number of genes. Interestingly, depletion of Sin3B led to compensatory increases in Sin3A recruitment at certain target loci, but Sin3B was never found to compensate for Sin3A loss. Thus, our analyses describe a novel transcriptional role for Sin3A and Sin3B proteins associated with maintenance of differentiated muscle cells. PMID 20956564 GEOID GSE19968 AUTHORS van Oevelen C,Bowman C,Pellegrino J,Asp P,Cheng J,Parisi F,Micsinai M,Kluger Y,Chu A,Blais A,David G,Dynlacht BD CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1S: Sin3A targets only FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1110018J18Rik,1810031K17Rik,2010305A19Rik,2310039H08Rik,2310061F22Rik,2410129H14Rik,2610024G14Rik,2810004N23Rik,3110049J23Rik,4632428N05Rik,4833439L19Rik,4930547N16Rik,5830457O10Rik,6330578E17Rik,8430410K20Rik,Abcc5,Abhd6,Abi2,Actr1b,Ahcy,Ankrd13b,Ankrd26,Anxa5,Appl2,Arhgap22,Arhgap5,Arpc1b,Asxl1,Atp6v1a,Bat4,Baz1a,Bbs5,Bcl2l11,Blzf1,Btbd6,Btd,Cab39l,Camk2a,Ccdc21,Ccdc71,Cct5,Cd3eap,Cdh6,Cep68,Chchd4,Cks1b,Clcn3,Clcn5,Cmas,Coq10b,Creb1,D11Wsu47e,Dap3,Dclre1b,Dctd,Ddx51,Dpagt1,Dpp3,Dtl,Dusp10,Dusp2,Dusp7,E2f6,Eda2r,Eif2b1,Enoph1,Erf,Ergic1,Ergic3,Etfb,Fam114a2,Fam53b,Fam65a,Fbxl8,Fhit,Flii,Ftl1,Gemin5,Gfer,Glt25d1,Gm129,Gng5,Gnl2,Gnptab,Gns,Gpc5,Gtpbp2,Hax1,Hipk2,Hmga1,Hmox1,Hoxc8,Hp1bp3,Hs2st1,Hsp90b1,Idh3a,Ing5,Iqcb1,Kank2,Kif17,Ldlr,Lif,Lin28,Lmln,LOC100233175,Lpcat3,Lrig1,Map3k7ip3,Mbtd1,Mctp2,Med15,Mfsd5,Mina,Mink1,Mlycd,Mrp63,Mrps16,Mrps33,Mrps36,Mtrf1l,Mxi1,Myo6,N6amt1,Nap1l4,Ndor1,Ndrg1,Nfil3,Nln,Nmd3,Nop16,Nppb,Nrm,Nsun3,Ogfod2,Ogn,Ola1,OTTMUSG00000000997,Parg,Pfkl,Pgls,Phf5a,Phkb,Pibf1,Pik3ip1,Pkp4,Pmm2,Pms2,Pnpla6,Pop7,Ppp1r11,Ppp2r2a,Ppp2r3c,Ppp3cb,Prrg4,Ptdss2,Ptplad1,Ptpn1,Rad51ap1,Rae1,Rala,Rara,Rcn1,Rhbdd2,Ric8,Rnf114,Rnf13,Rnf181,Rpp38,Rps24,Rps9,Rpsa,Scamp2,Sclt1,Sdc1,Serf1,Sh3gl1,Sipa1l1,Slc12a9,Slc25a40,Slc35a5,Slc39a3,Slc7a6os,Snx26,Sod2,Sorcs2,Sstr1,St6gal1,Stk19,Suclg2,Supt6h,Surf2,Tac4,Tbc1d24,Tbca,Terf2ip,Tfb1m,Thoc3,Tjp1,Tmco3,Tmem206,Tmem49,Tomm34,Trmt6,Trpv2,Tsen54,Txnrd1,Uchl3,Urb2,Usp5,Vamp3,Vamp4,Vps35,Vps52,Wwp2,Zbtb5,Zcchc24,Zdhhc20,Zfp189,Zfp248,Zfp667,Zfp84,Zwilch GENE_SYMBOLS PRXL2C,CNPPD1,COA7,C6orf226,CTU2,MZT1,NOA1,C1orf131,PBLD,VSIR,KIAA1191,PARPBP,CHTF8,COA5,MSANTD4,ABCC5,ABHD6,ABI2,ACTR1B,AHCY,ANKRD13B,ANKRD26,ANXA5,APPL2,ARHGAP22,ARHGAP5,ARPC1B,ASXL1,ATP6V1A,GPANK1,BAZ1A,BBS5,BCL2L11,BLZF1,BTBD6,BTD,CAB39L,CAMK2A,CEP85,CCDC71,CCT5,POLR1G,CDH6,CEP68,CHCHD4,CKS1B,CLCN3,CLCN5,CMAS,COQ10B,CREB1,C17orf80,DAP3,DCLRE1B,DCTD,DDX51,DPAGT1,DPP3,DTL,DUSP10,DUSP2,DUSP7,E2F6,EDA2R,EIF2B1,ENOPH1,ERF,ERGIC1,ERGIC3,ETFB,FAM114A2,FAM53B,RIPOR1,FBXL8,FHIT,FLII,FTL,GEMIN5,GFER,COLGALT1,CIART,GNG5,GNL2,GNPTAB,GNS,GPC5,GTPBP2,HAX1,HIPK2,HMGA1,HMOX1,HOXC8,HP1BP3,HS2ST1,HSP90B1,IDH3A,ING5,IQCB1,KANK2,KIF17,GON7,LDLR,LIF,LIN28A,LMLN,LPCAT3,LRIG1,TAB3,MBTD1,MCTP2,MED15,MFSD5,RIOX2,MINK1,MLYCD,MRPL57,MRPS16,MRPS33,MRPS36,MTRF1L,MXI1,MYO6,N6AMT1,NAP1L4,NDOR1,NDRG1,NFIL3,NLN,NMD3,NOP16,NPPB,NRM,NSUN3,,OGFOD2,OGN,OLA1,PARG,PFKL,PGLS,PHF5A,PHKB,PIBF1,PIK3IP1,PKP4,PMM2,PMS2,PNPLA6,POP7,PPP1R11,PPP2R2A,PPP2R3C,PPP3CB,PRRG4,PTDSS2,HACD3,PTPN1,RAD51AP1,RAE1,RALA,RARA,RCN1,RHBDD2,RIC8A,RNF114,RNF13,RNF181,RPP38,RPS24,RPS9,RPSA,SCAMP2,SCLT1,SDC1,SERF1A,SH3GL1,SIPA1L1,SLC12A9,SLC25A40,SLC35A5,SLC39A3,SLC7A6OS,ARHGAP33,SOD2,SORCS2,SSTR1,ST6GAL1,STK19,SUCLG2,SUPT6H,SURF2,TAC4,TBC1D24,TBCA,TERF2IP,TFB1M,THOC3,TJP1,TMCO3,PACC1,VMP1,TOMM34,TRMT6,TRPV2,TSEN54,TXNRD1,UCHL3,URB2,USP5,VAMP3,VAMP4,VPS35,VPS52,WWP2,ZBTB5,ZCCHC24,ZDHHC20,ZNF189,ZNF248,ZNF667,ZNF565,ZWILCH FOUNDER_NAMES