STANDARD_NAME VOIGT_PBMC_FLUARIX_AGE_50_74YO_FEMALES_VS_MALES_0DY_TO_28D_UP SYSTEMATIC_NAME M41079 COLLECTION C7:VAX MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/VOIGT_PBMC_FLUARIX_AGE_50_74YO_FEMALES_VS_MALES_0DY_TO_28D_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in peripheral blood mononuclear cell females vs males in adults (50-74) (females) after exposure to Fluarix , time point 0D, 3DY, 28D. Comment: Caucasian adults (50-74); See Suppl Table 6 for full DE gene list, time point 0D, 3DY, 28D combined (identical signatures) DESCRIPTION_FULL Background: Sex differences in immune responses to influenza vaccine may impact efficacy across populations. Methods: In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody titers, B-cell ELISPOT response, PBMC transcriptomics, and PBMC cell compositions at 0, 3, and 28 days post-immunization with the 2010/11 seasonal inactivated influenza vaccine. Results: We identified higher B-cell ELISPOT responses in females than males. Potential mechanisms for sex effects were identified in four gene clusters related to T, NK, and B cells. Mediation analysis indicated that sex-dependent expression in T and NK cell genes can be partially attributed to higher CD4+ T cell and lower NK cell fractions in females. We identified strong sex effects in 135 B cell genes whose expression correlates with ELISPOT measures, and found that cell subset differences did not explain the effect of sex on these genes' expression. Post-vaccination expression of these genes, however, mediated 41% of the sex effect on ELISPOT responses. Conclusions: These results improve our understanding of sexual dimorphism in immunity and influenza vaccine response. PMID 30873150 GEOID AUTHORS Voigt EA,Ovsyannikova IG,Kennedy RB,Grill DE,Goergen KM,Schaid DJ,Poland GA CONTRIBUTOR HIPC SIGNATURES CONTRIBUTOR_ORG NIAID/HIPC SIGNATURES EXACT_SOURCE Table 2 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400991/table/T2/ SOURCE_MEMBERS ADD2,BLNK,CD19,CD22,CD40,CDCA7L,DPF3,FAM129C,FCRL2,FCRL5,KHDRBS2,MOXD1,NXPH4,PAWR,PTPRK,RALGPS2,SPIB,STAP1,TCL6,TSPAN13 GENE_SYMBOLS ADD2,BLNK,CD19,CD22,CD40,CDCA7L,DPF3,NIBAN3,FCRL2,FCRL5,KHDRBS2,MOXD1,NXPH4,PAWR,PTPRK,RALGPS2,SPIB,STAP1,TCL6,TSPAN13 FOUNDER_NAMES