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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="VOIGT_PBMC_FLUARIX_AGE_50_74YO_FEMALES_VS_MALES_0DY_TO_28D_UP" SYSTEMATIC_NAME="M41079" HISTORICAL_NAMES="" PMID="30873150" AUTHORS="Voigt EA,Ovsyannikova IG,Kennedy RB,Grill DE,Goergen KM,Schaid DJ,Poland GA" GEOID="" EXACT_SOURCE="Table 2" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400991/table/T2/" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="HIPC SIGNATURES" CONTRIBUTOR_ORG="NIAID/HIPC SIGNATURES" DESCRIPTION_BRIEF="Genes up-regulated in peripheral blood mononuclear cell females vs males in adults (50-74) (females) after exposure to Fluarix , time point 0D, 3DY, 28D. Comment: Caucasian adults (50-74); See Suppl Table 6 for full DE gene list, time point 0D, 3DY, 28D combined (identical signatures)" DESCRIPTION_FULL="&lt;b&gt;Background:&lt;/b&gt; Sex differences in immune responses to influenza vaccine may impact efficacy across populations. &lt;b&gt;Methods:&lt;/b&gt; In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody titers, B-cell ELISPOT response, PBMC transcriptomics, and PBMC cell compositions at 0, 3, and 28 days post-immunization with the 2010/11 seasonal inactivated influenza vaccine. &lt;b&gt;Results:&lt;/b&gt; We identified higher B-cell ELISPOT responses in females than males. Potential mechanisms for sex effects were identified in four gene clusters related to T, NK, and B cells. Mediation analysis indicated that sex-dependent expression in T and NK cell genes can be partially attributed to higher CD4+ T cell and lower NK cell fractions in females. We identified strong sex effects in 135 B cell genes whose expression correlates with ELISPOT measures, and found that cell subset differences did not explain the effect of sex on these genes' expression. Post-vaccination expression of these genes, however, mediated 41% of the sex effect on ELISPOT responses. &lt;b&gt;Conclusions:&lt;/b&gt; These results improve our understanding of sexual dimorphism in immunity and influenza vaccine response." TAGS="" MEMBERS="ADD2,BLNK,CD19,CD22,CD40,CDCA7L,DPF3,FAM129C,FCRL2,FCRL5,KHDRBS2,MOXD1,NXPH4,PAWR,PTPRK,RALGPS2,SPIB,STAP1,TCL6,TSPAN13" MEMBERS_SYMBOLIZED="ADD2,BLNK,CD19,CD22,CD40,CDCA7L,DPF3,FCRL2,FCRL5,KHDRBS2,MOXD1,NIBAN3,NXPH4,PAWR,PTPRK,RALGPS2,SPIB,STAP1,TCL6,TSPAN13" MEMBERS_EZID="11247,119,124903372,199786,202559,26002,26228,27075,29760,5074,55103,55536,5796,6689,79368,8110,83416,930,933,958" MEMBERS_MAPPING="ADD2,ADD2,119|BLNK,BLNK,29760|CD19,CD19,930|CD22,CD22,933|CD40,CD40,958|CDCA7L,CDCA7L,55536|DPF3,DPF3,8110|FAM129C,NIBAN3,199786|FCRL2,FCRL2,79368|FCRL5,FCRL5,83416|KHDRBS2,KHDRBS2,202559|MOXD1,MOXD1,26002|NXPH4,NXPH4,11247|PAWR,PAWR,5074|PTPRK,PTPRK,5796|RALGPS2,RALGPS2,55103|SPIB,SPIB,6689|STAP1,STAP1,26228|TCL6,TCL6,124903372|TSPAN13,TSPAN13,27075" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="VAX"/>
</MSIGDB>
